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Mohammad S Alrashdan, Nicola Cirillo, Michael McCullough
Lichen planus (LP) is a common chronic inflammatory condition that can affect skin and mucous membranes, including the oral mucosa. Because of the anatomic, physiologic and functional peculiarities of the oral cavity, the oral variant of LP (OLP) requires specific evaluations in terms of diagnosis and management. In this comprehensive review, we discuss the current developments in the understanding of the etiopathogenesis, clinical-pathologic presentation, and treatment of OLP, and provide follow-up recommendations informed by recent data on the malignant potential of the disease as well as health economics evaluations...
October 2016: Archives of Dermatological Research
Samer El Hayek, Lynn Bitar, Layal H Hamdar, Fadi G Mirza, Georges Daoud
Poly Cystic Ovarian Syndrome (PCOS) is one of the most common metabolic and reproductive disorders among women of reproductive age. Women suffering from PCOS present with a constellation of symptoms associated with menstrual dysfunction and androgen excess, which significantly impacts their quality of life. They may be at increased risk of multiple morbidities, including obesity, insulin resistance, type II diabetes mellitus, cardiovascular disease (CVD), infertility, cancer, and psychological disorders. This review summarizes what the literature has so far provided from guidelines to diagnosis of PCOS...
2016: Frontiers in Physiology
Candemir Ceran, Ersin Aksam, Cagla Cicek, Soner Tezcan, Mustafa Erol Demirseren
BACKGROUND: Many methods have been used for correcting tethered and depressed scars, but most of these methods have had unsatisfying results and ended up with recurrence. The aim of this study is to present a new surgical technique that overcomes these problems. MATERIALS AND METHODS: Twenty-two depressed scars were corrected using the layered dermal support technique. With this technique, the depressed part of the scar is deepithelialized and used in a layered fashion to support the skin flaps...
October 2016: Aesthetic Plastic Surgery
P Staubach, T Zuberbier, C Vestergaard, F Siebenhaar, E Toubi, G Sussman
This supplement reports proceedings of the second international Global Urticaria Forum, which was held in Berlin, Germany in November 2015. Despite the clear international guideline, there remain a number of controversies and challenges in the management of patients with chronic urticaria (CU). As a result of major advancements in urticaria over the past 4 years, the current EAACI/GA(2) LEN/EDF/WAO urticaria guideline treatment algorithm requires updating. Case studies from patients with chronic spontaneous urticaria (CSU) [also called chronic idiopathic urticaria (CIU)], chronic inducible urticaria (CIndU) or diseases and syndromes related to CU are useful in describing and exploring challenges in disease management...
July 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
Kamran Balighi, Maryam Daneshpazhooh, Vahideh Lajevardi, Shahin Talebi, Arghavan Azizpour
BACKGROUND/OBJECTIVES: Isotretinoin is commonly used in the treatment of acne vulgaris. While one of the more common side-effects is cheilitis, we have observed an increased incidence of cheilitis prior to the commencement of systemic isotretinoin. The aim of this study was to assess the prevalence of cheilitis among acne vulgaris patients. METHODS: A non-interventional cross-sectional study of patients with acne vulgaris. Patients with previous use of systemic retinoids were excluded...
March 21, 2016: Australasian Journal of Dermatology
R Nagi, Y-B Reddy-Kantharaj, N Rakesh, S Janardhan-Reddy, S Sahu
BACKGROUND: Earlier detection of oral squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMD) is essential for dental professionals to improve patient survival rates. The aim of this systematic review is to to evaluate the effectiveness of devices that utilise the principles of chemiluminescence and tissue autofluorescence as adjuncts in the detection of OSCC and OPMD. MATERIAL AND METHODS: The electronic retrieval systems and databases searched for relevant articles were PubMed [MEDLINE] and Science direct...
2016: Medicina Oral, Patología Oral y Cirugía Bucal
Raquel Sucupira Andrade Lima, Gustavo Ávila Maquiné, Renato Cândido da Silva Junior, Antonio Pedro Mendes Schettini, Mônica Santos
Granuloma faciale is a rare dermatosis of chronic course, benign, usually asymptomatic, first described in 1945 by Wingley. It is characterized by the appearance of well-defined, single or multiple papules, plaques and nodules, predominantly located in sun-exposed areas, especially the face. In this work we report the case of a female patient, 58 years old, evolving for ten years with multiple erythematous-brownish and asymptomatic papules on the face, whose histological examination confirmed the diagnosis of granuloma faciale...
September 2015: Anais Brasileiros de Dermatologia
Maria K Hordinsky
Selection of a therapy for a patient with alopecia areata (AA) is frequently based on the age of the patient, disease extent, perhaps disease duration, patient expectations, cost of therapy in terms of time commitment, and financial resources, as well as the results of screening laboratory studies that rule out the presence of other co-morbidities such as anemia, low iron stores, thyroid abnormalities, low vitamin D, or other autoimmune diseases. Although there is currently no cure for AA and no universally proven therapy that induces and sustains remission, many therapies are available which can be of benefit to both affected children and adults...
November 2015: Journal of Investigative Dermatology. Symposium Proceedings
Yuichiro Tsunemi, Ryokichi Irisawa, Hiromu Yoshiie, Betsy Brotherton, Hisahiro Ito, Ryoji Tsuboi, Makoto Kawashima, Michael Manyak
Androgenetic alopecia is an androgen-induced pattern of progressive hair loss, which occurs in genetically predisposed people. This study aimed to determine long-term safety, tolerability and efficacy of dutasteride 0.5 mg, an inhibitor of 5-α-reductase, in Japanese male patients with androgenetic alopecia. This was a multicenter, open-label, prospective outpatient study ( NCT01831791, GSK identifier ARI114264) in which patients took dutasteride 0.5 mg p.o. once daily for 52 weeks. Primary end-points included adverse event assessment, incidence of drug-related adverse event and premature discontinuations...
September 2016: Journal of Dermatology
Ai-Young Lee
Melasma is a common skin pigmentation condition. Given therapeutic difficulty as one of the biggest concerns, understanding of the etiology and pathogenesis of melasma becomes essential. UV irradiation, female sex hormones, and inflammatory processes are addressed as triggering factors with genetic predisposition. The mechanism of UV-induced melanogenesis has been extensively investigated as a model system to study melasma pathogenesis. Hitherto, treatment modalities for melasma are similar to other hyperpigmentation disorders...
November 2015: Pigment Cell & Melanoma Research
Emily Z Hejazi, Victoria P Werth
Cutaneous lupus erythematosus (CLE) includes a broad range of dermatologic manifestations, which may or may not be associated with systemic disease. Recent studies in this area continue to shape our understanding of this disease and treatment options. Epidemiologic studies have found an incidence of CLE of 4.30 per 100,000, which approaches similar analysis for systemic lupus erythematosus (SLE). Although there have been extensive efforts to define SLE, the classification of CLE and its subgroups remains a challenge...
April 2016: American Journal of Clinical Dermatology
Yong Hyun Jang, Jin Sub Lee, Sang Lim Kim, Seong Geun Chi, Weon Ju Lee, Seok-Jong Lee, Shin-Woo Kim, Ki Bum Park, Won Kee Lee, Young Hoon Jeon, Do Won Kim
No abstract text is available yet for this article.
December 2015: Annals of Dermatology
Hemin Lee, Jung U Shin, Kwang Hoon Lee
No abstract text is available yet for this article.
December 2015: Annals of Dermatology
Soo-Eun Jung, Kwang Hyun Cho, Mi Woo Lee, You Chan Kim
No abstract text is available yet for this article.
December 2015: Annals of Dermatology
Jéssica González-Ramos, Elena Sendagorta-Cudós, Guillermo González-López, Ander Mayor-Ibarguren, Rosa Feltes-Ochoa, Pedro Herranz-Pinto
Pachyonychia congenita (PC) is a rare genodermatosis caused by a mutation in keratin genes, which can lead to hypertrophic nail dystrophy and focal palmoplantar keratoderma (predominantly plantar), amongst other manifestations. Painful blisters and callosities, sometimes exacerbated by hyperhidrosis, are major issues that can have a significant impact on patient quality of life. Many alternative treatments for this condition have been applied with variable and partial clinical response, but a definitive cure for this disease has yet to be discovered...
January 2016: Dermatologic Therapy
Carina M Woodruff, Abbas M Charlie, Kieron S Leslie
Hidradenitis suppurativa is a chronic inflammatory disease of apocrine gland-bearing skin. Although immunologic derangements, genetic predisposition, obesity, and smoking are likely important factors, the pathogenesis of the disease and the effect of available treatments on disease course have not been fully elucidated. In the absence of proper treatment, chronic inflammation results in diffuse scarring and a wide array of complications, including the development of cutaneous squamous cell carcinoma. This severe and chronic disease can have detrimental effects on self-esteem and quality of life...
December 2015: Mayo Clinic Proceedings
Nooshin Bagherani
No abstract text is available yet for this article.
December 2, 2015: Dermatologic Therapy
Wedad Z Mostafa, Rehab A Hegazy
The "sunshine" vitamin is a hot topic that attracted ample attention over the past decades, specially that a considerable proportion of the worldwide population are deficient in this essential nutrient. Vitamin D was primarily acknowledged for its importance in bone formation, however; increasing evidence point to its interference with the proper function of nearly every tissue in our bodies including brain, heart, muscles, immune system and skin. Thereby its deficiency has been incriminated in a long panel of diseases including cancers, autoimmune diseases, cardiovascular and neurological disorders...
November 2015: Journal of Advanced Research
Andreas Foustanos, Georgios Drimouras, Konstantinos Panagiotopoulos
BACKGROUND: Descent of the lateral aspect of the brow is one of the earliest signs of aging. The purpose of this study was to describe an open surgical technique for lateral brow lifts, with the goal of achieving reliable, predictable, and long-lasting results. METHODS: An incision was made behind and parallel to the temporal hairline, and then extended deeper through the temporoparietal fascia to the level of the deep temporal fascia. Dissection was continued anteriorly on the surface of the deep temporal fascia and subperiosteally beyond the temporal crest, to the level of the superolateral orbital rim...
September 2015: Archives of Plastic Surgery
S Ud-Din, D McGeorge, A Bayat
Striae distensae (SD) are common dermal lesions, with significant physical and psychological impact. Many therapeutic modalities are available but none can completely eradicate SD. The most common therapy is the application of topicals used both therapeutically and prophylactically. Even though there are many commercially available topical products, not all have sufficient level of evidence to support their continued use in SD. The aim here was to assess the evidence for the use of topicals in SD and to propose a structured approach in managing SD...
February 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
2015-12-21 23:59:21
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