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Gynae

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45 papers 0 to 25 followers
https://www.readbyqxmd.com/read/28434653/a-revised-prediction-model-for-natural-conception
#1
Alexandra J Bensdorp, Jan Willem van der Steeg, Pieternel Steures, J Dik F Habbema, Peter G A Hompes, Patrick M M Bossuyt, Fulco van der Veen, Ben W J Mol, Marinus J C Eijkemans
One of the aims in reproductive medicine is to differentiate between couples that have favourable chances of conceiving naturally and those that do not. Since the development of the prediction model of Hunault, characteristics of the subfertile population have changed. The objective of this analysis was to assess whether additional predictors can refine the Hunault model and extend its applicability. Consecutive subfertile couples with unexplained and mild male subfertility presenting in fertility clinics were asked to participate in a prospective cohort study...
March 28, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28244213/role-of-androgen-ratios-in-the-prediction-of-the-metabolic-phenotype-in-polycystic-ovary-syndrome
#2
Sonia Minooee, Fahimeh Ramezani Tehrani, Maryam Tohidi, Fereidoun Azizi
OBJECTIVE: To identify the androgen ratio that best predicts insulin resistance and metabolic syndrome among women with polycystic ovary syndrome (PCOS). METHODS: Data for 180 women with PCOS and 180 healthy controls were extracted from two previous studies in Iran (conducted during 2008-2010 and 2011-2013). The diagnosis of PCOS was based on the Rotterdam criteria. The serum concentration of different androgens was measured. Receiver operating characteristic curve analysis was used to assess the ability of various androgen ratios to predict insulin resistance and metabolic syndrome...
May 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/27920066/new-concepts-for-an-old-problem-the-diagnosis-of-endometrial-hyperplasia
#3
Peter A Sanderson, Hilary O D Critchley, Alistair R W Williams, Mark J Arends, Philippa T K Saunders
BACKGROUND: Endometrial hyperplasia (EH) is a uterine pathology representing a spectrum of morphological endometrial alterations. It is predominantly characterized by an increase in the endometrial gland-to-stroma ratio when compared to normal proliferative endometrium. The clinical significance of EH lies in the associated risk of progression to endometrioid endometrial cancer (EC) and 'atypical' forms of EH are regarded as premalignant lesions. Traditional histopathological classification systems for EH exhibit wide and varying degrees of diagnostic reproducibility and, as a consequence, standardized patient management can be challenging...
March 1, 2017: Human Reproduction Update
https://www.readbyqxmd.com/read/28416368/nutritional-management-in-women-with-polycystic-ovary-syndrome-a-review-study
#4
REVIEW
Zeinab Faghfoori, Siavash Fazelian, Mahdi Shadnoush, Reza Goodarzi
Polycystic ovary syndrome (PCOS) is endocrine disorder in women of reproductive age, which leads to reproductive, hormonal and metabolic abnormalities. Due to the presence of insulin resistance, PCOS increases the risk of chronic diseases like type 2 diabetes, hypertension, lipid disorders, cardiovascular diseases and malignancies such as breast and endometrial cancer. The actual cause of this syndrome is unknown but environmental factors such as dietary habits play an important role in prevention and treatment and lifestyle modifications are the most important therapeutic strategies in these patients...
April 5, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28368518/functional-hypothalamic-amenorrhea-an-endocrine-society-clinical-practice-guideline
#5
Catherine M Gordon, Kathryn E Ackerman, Sarah L Berga, Jay R Kaplan, George Mastorakos, Madhusmita Misra, M Hassan Murad, Nanette F Santoro, Michelle P Warren
Cosponsoring Associations: The American Society for Reproductive Medicine, the European Society of Endocrinology, and the Pediatric Endocrine Society. This guideline was funded by the Endocrine Society. Objective: To formulate clinical practice guidelines for the diagnosis and treatment of functional hypothalamic amenorrhea (FHA). Participants: The participants include an Endocrine Society-appointed task force of eight experts, a methodologist, and a medical writer...
May 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28469285/abnormal-vaginal-pap-test-after-hysterectomy-in-human-immunodeficiency-virus-infected-women
#6
Stephanie Smeltzer, Xiaoying Yu, Kathleen Schmeler, Judy Levison
OBJECTIVE: To evaluate the prevalence of abnormal vaginal cytology and vaginal intraepithelial neoplasia (VAIN) and vaginal cancer in human immunodeficiency virus (HIV)-infected women with no history of abnormal cytologic screening who had a hysterectomy for conditions other than cervical dysplasia and cancer; and to explore the risk factors associated with VAIN and vaginal cancer. METHODS: A retrospective cohort study was performed identifying 238 women between January 2000 to January 2015 with a history of HIV, previous hysterectomy, and no previous abnormal Pap tests...
May 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27302188/the-effect-of-salpingectomy-on-ovarian-reserve-and-ovarian-function
#7
REVIEW
Feng Qin, Dan-Feng Du, Xue-Lian Li
BACKGROUND: The effect of salpingectomy on ovarian reserve and ovarian function is still a controversial issue, and more investigations are needed. OBJECTIVE: The aim of this study was to determine the effect of salpingectomy on ovarian reserve and ovarian function. STUDY STRATEGY: PubMed, Embase, Medline, Web of Knowledge, and the Cochrane trial register were searched. SELECTION CRITERIA: Studies must have similar study method and be published in English; clear data can be extracted from full test...
June 2016: Obstetrical & Gynecological Survey
https://www.readbyqxmd.com/read/28433735/outpatient-endometrial-aspiration-an-alternative-to-methotrexate-for-pregnancy-of-unknown-location
#8
Iris G Insogna, Leslie V Farland, Stacey A Missmer, Elizabeth S Ginsburg, Paula C Brady
BACKGROUND: Pregnancies of unknown location with abnormal beta-human chorionic gonadotropin trends are frequently treated as presumed ectopic pregnancies with methotrexate. Preliminary data suggest that outpatient endometrial aspiration may be an effective tool to diagnose pregnancy location, while also sparing women exposure to methotrexate. OBJECTIVE: The purpose of this study was to evaluate the utility of an endometrial sampling protocol for the diagnosis of pregnancies of unknown location after in vitro fertilization...
April 19, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/26900391/probiotics-in-prevention-and-treatment-of-obesity-a-critical-view
#9
REVIEW
Nazarii Kobyliak, Caterina Conte, Giovanni Cammarota, Andreana P Haley, Igor Styriak, Ludovit Gaspar, Jozef Fusek, Luis Rodrigo, Peter Kruzliak
The worldwide prevalence of obesity more than doubled between 1980 and 2014. The obesity pandemic is tightly linked to an increase in energy availability, sedentariness and greater control of ambient temperature that have paralleled the socioeconomic development of the past decades. The most frequent cause which leads to the obesity development is a dysbalance between energy intake and energy expenditure. The gut microbiota as an environmental factor which influence whole-body metabolism by affecting energy balance but also inflammation and gut barrier function, integrate peripheral and central food intake regulatory signals and thereby increase body weight...
2016: Nutrition & Metabolism
https://www.readbyqxmd.com/read/27457114/metabolic-screening-in-patients-with-polycystic-ovary%C3%A2-syndrome-is-largely-underutilized-among-obstetrician-gynecologists
#10
Amy S Dhesi, Katie L Murtough, Jonathan K Lim, Jay Schulkin, Peter G McGovern, Michael L Power, Sara S Morelli
Women with polycystic ovary syndrome have substantially higher rates of insulin resistance, impaired glucose tolerance, type 2 diabetes, dyslipidemia, and metabolic syndrome when compared with women without the disease. Given the high prevalence of these comorbidities, guidelines issued by the American College of Obstetricians and Gynecologists and the Endocrine Society recommend that all women with polycystic ovary syndrome undergo screening for impaired glucose tolerance and dyslipidemia with a 2 hour 75 g oral glucose tolerance test and fasting lipid profile upon diagnosis and also undergo repeat screening every 2-5 years and every 2 years, respectively...
November 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27465972/the-relationship-between-the-vaginal-microbiome-and-human-health
#11
M R Millar
No abstract text is available yet for this article.
January 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/26914398/the-role-of-anti-m%C3%A3-llerian-hormone-in-the-pathogenesis-and-pathophysiological-characteristics-of-polycystic-ovary-syndrome
#12
REVIEW
Xinyu Qi, Yanli Pang, Jie Qiao
Polycystic ovarian syndrome (PCOS) is one of the major causes of anovulatory infertility. High levels of anti-Müllerian hormone (AMH) in the serum of PCOS patients participate in the major steps of the anovulation, and are related to pathogenesis and pathophysiological characteristic of PCOS, including the interactions of AMH with intra/extra ovarian factors like FSH, LH, androgen, and estrogen, as well as the role of AMH in folliculogenesis of PCOS. AMH promotes follicular atresia which may participate in the follicle pattern in PCOS patients...
April 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27214299/metformin-non-glycemic-effects-and-potential-novel-indications
#13
Abeer Anabtawi, John M Miles
Metformin is the most commonly prescribed drug for the treatment of type 2 diabetes because of its apparent robust effects in reducing cardiovascular risk. The United Kingdom Prospective Diabetes Study suggests that metformin reduces the risk of myocardial infarction, and more recent retrospective studies have shown an association between metformin and a reduction in stroke, atrial fibrillation and all-cause mortality. The mechanism(s) explaining these putative benefits are not clear but may involve decreased energy intake (with attendant weight loss), improvement in lipids, and lowering of blood pressure; a review of selected literature suggests that metformin lowers blood pressure when it is elevated, but not when it is normal...
May 23, 2016: Endocrine Practice
https://www.readbyqxmd.com/read/27182828/role-of-metformin-in-women-s-health-review-of-its-current-place-in-clinical-practice-and-emerging-indications-for-future
#14
REVIEW
Vikram Sinai Talaulikar, Thomas Tang, Ephia Yasmin
IMPORTANCE: Metformin, an oral antihyperglycemic drug, acts as an insulin sensitizer in the treatment of type 2 diabetes mellitus. It has also been widely used in the treatment of polycystic ovary syndrome (PCOS) and gestational diabetes mellitus. Although randomized clinical trials have failed to establish its superiority over other forms of treatment, metformin continues to be a treatment option in specific subgroups of women either alone or as an adjunct with other therapies in management of PCOS...
May 2016: Obstetrical & Gynecological Survey
https://www.readbyqxmd.com/read/27381960/disorders-of-puberty-take-a-good-history
#15
Selma Feldman Witchel
No abstract text is available yet for this article.
July 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27409811/human-gut-microbes-impact-host-serum-metabolome-and-insulin-sensitivity
#16
Helle Krogh Pedersen, Valborg Gudmundsdottir, Henrik Bjørn Nielsen, Tuulia Hyotylainen, Trine Nielsen, Benjamin A H Jensen, Kristoffer Forslund, Falk Hildebrand, Edi Prifti, Gwen Falony, Emmanuelle Le Chatelier, Florence Levenez, Joel Doré, Ismo Mattila, Damian R Plichta, Päivi Pöhö, Lars I Hellgren, Manimozhiyan Arumugam, Shinichi Sunagawa, Sara Vieira-Silva, Torben Jørgensen, Jacob Bak Holm, Kajetan Trošt, Karsten Kristiansen, Susanne Brix, Jeroen Raes, Jun Wang, Torben Hansen, Peer Bork, Søren Brunak, Matej Oresic, S Dusko Ehrlich, Oluf Pedersen
Insulin resistance is a forerunner state of ischaemic cardiovascular disease and type 2 diabetes. Here we show how the human gut microbiome impacts the serum metabolome and associates with insulin resistance in 277 non-diabetic Danish individuals. The serum metabolome of insulin-resistant individuals is characterized by increased levels of branched-chain amino acids (BCAAs), which correlate with a gut microbiome that has an enriched biosynthetic potential for BCAAs and is deprived of genes encoding bacterial inward transporters for these amino acids...
July 21, 2016: Nature
https://www.readbyqxmd.com/read/27406348/clinical-practice-polycystic-ovary-syndrome
#17
REVIEW
Christopher R McCartney, John C Marshall
No abstract text is available yet for this article.
July 7, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27359293/use-of-metformin-in-clinical-endocrinology
#18
COMMENT
J Michael Gonzalez-Campoy
CKD = chronic kidney disease DM = diabetes mellitus eGFR = estimated glomerular filtration rate FDA = Food & Drug Administration.
August 2016: Endocrine Practice
https://www.readbyqxmd.com/read/27419327/diagnosis-and-treatment-of-polycystic-ovary-syndrome
#19
Tracy Williams, Rami Mortada, Samuel Porter
Polycystic ovary syndrome is the most common endocrinopathy among reproductive-aged women in the United States, affecting approximately 7% of female patients. Although the pathophysiology of the syndrome is complex and there is no single defect from which it is known to result, it is hypothesized that insulin resistance is a key factor. Metabolic syndrome is twice as common in patients with polycystic ovary syndrome compared with the general population, and patients with polycystic ovary syndrome are four times more likely than the general population to develop type 2 diabetes mellitus...
July 15, 2016: American Family Physician
https://www.readbyqxmd.com/read/27461818/diagnosing-endometriosis-ca125-rules-in-but-not-out
#20
W Foster
No abstract text is available yet for this article.
October 2016: BJOG: An International Journal of Obstetrics and Gynaecology
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