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Normal Pressure Hydrocephalus literature

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28 papers 25 to 100 followers
R Manet, N Fabre, E Moyse, B Laurent, E A Schmidt
INTRODUCTION: Headache is usually considered a key symptom of intracranial hypertension (ICHT). However, there are no published experimental data to support the concept that increased intracranial pressure (ICP) is painful in humans. MATERIALS AND METHODS: This prospective study was performed in 16 patients with suspected normal-pressure hydrocephalus, necessitating a lumbar infusion test with measurement of cerebrospinal fluid (CSF) hydrodynamics. During the test, ICP was increased from baseline to a plateau...
2016: Acta Neurochirurgica. Supplement
Masaatsune Ishikawa, Hisayuki Oowaki, Masahiro Takezawa, Tomofumi Takenaka, Shigeki Yamada, Kazuo Yamamoto, Shinichiro Okamoto
Idiopathic normal-pressure hydrocephalus (iNPH) has become socially significant in Japan. Japanese guidelines for iNPH in 2011 described the diagnostic importance of "disproportionately enlarged subarachnoid space hydrocephalus" (DESH) on magnetic resonance imaging (MRI). However, some patients with iNPH have equivocal or no features of DESH. To clarify the diversity of MRI findings in iNPH, we classified iNPH into three types based on MRI findings. Using this, we investigate predictable MRI findings for shunt effectiveness in iNPH...
2016: Acta Neurochirurgica. Supplement
Robert Hamilton, Jennifer Fuller, Kevin Baldwin, Paul Vespa, Xiao Hu, Marvin Bergsneider
INTRODUCTION: The diversion of cerebrospinal fluid (CSF) remains the principal treatment option for patients with normal-pressure hydrocephalus (NPH). External lumbar drain (ELD) and overnight intracranial pressure (ICP) monitoring are popular prognostic tests for differentiating which patients will benefit from shunting. Using the morphological clustering and analysis of continuous intracranial pulse (MOCAIP) algorithm to extract morphological metrics from the overnight ICP signal, we hypothesize that changes in the third peak of the ICP pulse pressure waveform can be used to differentiate ELD responders and nonresponders...
2016: Acta Neurochirurgica. Supplement
Omer Elsabbagh
Normal-pressure hydrocephalus is an almost curable disease, but the results of management are still not encouraging owing to the deceptive nature of the disease and its sensitivity to treatment. This has made the management of the disease controversial. The following self-documented report clarifies this. I have reported my experience in a scientific manner so that my colleagues can understand thoroughly certain facts related to intracranial hypertension. Achieving the optimal adjustment of the valve is a real challenge...
2016: Acta Neurochirurgica. Supplement
Hiroyuki Sato, Takayuki Koizumi, Daisuke Sato, Shin Endo, Syunichi Kato
The patient, a 79-year-old man, experienced a Hunt & Kosnik grade IV subarachnoid hemorrhage, presenting with sudden-onset coma and severe left hemiplegia. We performed cranial clipping surgery for a ruptured aneurysm on the right middle cerebral artery the same day. Post-operative recovery proceeded smoothly, with gradual improvements in disturbed consciousness and left hemiplegia. Three weeks post-operation, CT revealed low-density areas in the right frontal and temporal lobe, believed to be due to subarachnoid hemorrhage, as well as hydrocephaly...
June 2016: No Shinkei Geka. Neurological Surgery
Radek Frič, Per Kristian Eide
OBJECTIVE Several lines of evidence suggest common pathophysiological mechanisms in Chiari malformation Type I (CMI) and idiopathic intracranial hypertension (IIH). It has been hypothesized that tonsillar ectopy, a typical finding in CMI, is the result of elevated intracranial pressure (ICP) combined with a developmentally small posterior cranial fossa (PCF). To explore this hypothesis, the authors specifically investigated whether ICP is comparable in CMI and IIH and whether intracranial volumes (ICVs) are different in patients with CMI and IIH, which could explain the tonsillar ectopy in CMI...
June 24, 2016: Journal of Neurosurgery
He Huang, Jun Yang, Mark Luciano, Leah P Shriver
Idiopathic normal pressure hydrocephalus is a neurological disease caused by abnormal cerebrospinal fluid flow and presents with symptoms such as dementia. Current therapy involves the removal of excess cerebrospinal fluid by shunting. Not all patients respond to this therapy and biomarkers are needed that could facilitate the characterization of patients likely to benefit from this treatment. Here, we measure brain metabolism in normal pressure hydrocephalus patients by performing a novel longitudinal metabolomic profiling study of cerebrospinal fluid...
July 2016: Neurochemical Research
Morten Ziebell, Jørn Wetterslev, Magnus Tisell, Christian Gluud, Marianne Juhler
BACKGROUND: Since 1965 many ventriculo-peritoneal shunt systems have been inserted worldwide to treat hydrocephalus. The most frequent indication in adults is normal pressure hydrocephalus (NPH), a condition that can be difficult to diagnose precisely. Surgical intervention with flow-regulated and differential pressure-regulated ventriculo-peritoneal shunts remains controversial. Knowledge about the benefits and harms of these interventions is limited. OBJECTIVES: The objective of this review is to summarize the evidence on benefits and harms of flow-regulated versus differential pressure-regulated shunt valves for adult patients with NPH, based on reported findings of randomised clinical trials...
2013: Cochrane Database of Systematic Reviews
Ann Liu, Eric W Sankey, Ignacio Jusué-Torres, Mira A Patel, Benjamin D Elder, C Rory Goodwin, Jamie Hoffberger, Jennifer Lu, Daniele Rigamonti
INTRODUCTION: Idiopathic normal pressure hydrocephalus (iNPH) is a neurological disorder that classically presents with a triad of progressive gait impairment, urinary incontinence, and cognitive deterioration. Treatment predominantly involves ventriculoperitoneal (VP) shunting, but one alternative is ventriculoatrial (VA) shunting. This study sought to describe and evaluate the clinical outcomes of patients with iNPH primarily treated with VA shunting. MATERIALS AND METHODS: A retrospective review of patients with iNPH who were treated with VA shunting at a single institution, from 2003 to 2013, was performed...
April 2016: Clinical Neurology and Neurosurgery
Morgan Broggi, Veronica Redaelli, Giovanni Tringali, Francesco Restelli, Luigi Romito, Silvia Schiavolin, Fabrizio Tagliavini, Giovanni Broggi
OBJECTIVE: Idiopathic normal pressure hydrocephalus (iNPH) may present, besides the classic triad of symptoms, with extrapyramidal parkinsonianlike movement disorders. We present a randomized prospective study comparing adjustable ventriculoperitoneal (VP) shunt insertion plus dopamine oral therapy (group A) versus VP shunt alone (group B) in patients affected by iNPH associated with parkinsonism. METHODS: A detailed screening process included neurologic, neurosurgical, and neuropsychological evaluations, followed by a cerebrospinal fluid tap test and resistance outflow measurement...
June 2016: World Neurosurgery
Soon-Cheol Chung, Mi-Hyun Choi, Hyung-Sik Kim, Jung-Chul Lee, Sung-Jun Park, Ul-Ho Jeong, Ji-Hye Baek, Seon-Young Gim, Young Chil Choi, Beob-Yi Lee, Dae-Woon Lim, Boseong Kim
The purpose of this study is to investigate differences in and correlations between cognitive abilities and brain volumes in healthy control (HC), mild cognitive impairment (MCI), and Alzheimer's disease (AD) groups. The Korean Version of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD-K), which is used to diagnose AD, was used to measure the cognitive abilities of the study subjects, and the volumes of typical brain components related to AD diagnosis-cerebrospinal fluid (CSF), gray matter (GM), and white matter (WM)-were acquired...
May 2016: Clinical Anatomy
Ryszard Czepko, Krzysztof Cieslicki
BACKGROUND: Only a few reports have been published on the natural history of non-shunted patients suspected of having NPH. The aim of this study is to follow up a group of such cases. METHODS: It was possible to follow up 27 patients who had not been qualified for shunting after the primary diagnosis. An assessment of Hakim's triad was performed, together with an analysis of radiological parameters and the results of lumbar infusion tests (LITs), both on admission and at the later date (on average, after 5...
May 2016: Acta Neurochirurgica
Mario Mihalj, Krešimir Dolić, Krešimir Kolić, Vlatko Ledenko
OBJECTIVES: There is no accurate test for diagnosing normal pressure hydrocephalus or for screening for patients who will benefit from shunt surgery. Additional tests, such as cerebrospinal fluid tap test (CSF-TT), are often used in practice to provide further predictive value in detecting suitable patients for shunting. We performed a systematic review of the literature to evaluate the CSF-TT's effect on the outcome of main symptoms and on validity parameters in screening patients suitable for shunting...
March 15, 2016: Journal of the Neurological Sciences
Marta Picascia, Roberta Zangaglia, Sara Bernini, Brigida Minafra, Elena Sinforiani, Claudio Pacchetti
Idiopathic normal pressure hydrocephalus (iNPH) is a complex and still underestimated pathology. In the early stages, the cognitive profile is characterized mainly by impairments of attention, psychomotor speed and memory, suggesting frontal involvement; patients with more advanced iNPH show overall cognitive deterioration. The memory impairment, however, seems to be milder than that seen in Alzheimer's disease (AD). Clinical and neuroimaging data are crucial for the diagnosis of iNPH, but the presence of different variables, such as comorbidities, and the possible overlapping with other neurodegenerative diseases, AD in particular, make the differential diagnosis difficult...
October 2015: Functional Neurology
Y Yang, K Landin-Wilhelmsen, H Zetterberg, G Oleröd, J Isgaard, C Wikkelsö
BACKGROUND: Hypopituitarism has been reported in patients with idiopathic normal pressure hydrocephalus (iNPH), which could enhance characteristic symptoms like impaired wakefulness, gait, body balance, and subcortical cognitive deterioration. PURPOSE: To compare basal serum levels of pituitary and sex hormones and serum insulin-like growth factor-1 (S-IGF-1) in patients with iNPH and an age-matched control population, and to correlate the preoperative hormone levels with symptoms and signs pre-operatively and three months after surgery...
December 2015: Growth Hormone & IGF Research
Ryuji Sakakibara, Yoshitaka Uchida, Kazunari Ishii, Masaaki Hashimoto, Masaaki Ishikawa, Hiromitsu Kazui, Tatsuya Yamamoto, Tomoyuki Uchiyama, Fuyuki Tateno, Masahiko Kishi, Yohei Tsuyusaki, Yosuke Aiba, Hiromi Tateno, Takeki Nagao, Hitoshi Terada, Tsutomu Inaoka
AIMS OF STUDY: It is reported that severe bladder disorder in idiopathic normal-pressure hydrocephalus (iNPH) is predicted by right frontal hypoperfusion. However, it is not known whether bladder recovery is predicted by brain perfusion change after shunt surgery. To address this issue, we compared bladder and brain function before and after shunt surgery in iNPH. METHODS: We enrolled 75 patients in the study. Before and 12 months after shunt surgery, we analyzed brain perfusion by SPECT and bladder disorder by a specialized grading scale...
February 2016: International Urology and Nephrology
Renan M Pereira, Mariane T Suguimoto, Matheus F Oliveira, Juliana B Tornai, Ricardo A Amaral, Manoel Jacobsen Teixeira, Fernando Campos Gomes Pinto
Normal pressure hydrocephalus (NPH) is characterized by the triad of gait apraxia, dementia and urinary incontinence associated with ventriculomegaly and normal pressure of cerebrospinal fluid. Treatment is accomplished through the implantation of a ventricular shunt (VPS), however some complications are still frequent, like overdrainage due to siphon effect. This study analyses the performance of a valve with anti-siphon device (SPHERA®) in the treatment of patients with NPH and compares it with another group of patients with NPH who underwent the same procedure without anti-siphon mechanism (PS Medical® valve)...
January 2016: Arquivos de Neuro-psiquiatria
Doerthe Ziegelitz, Jonathan Arvidsson, Per Hellström, Mats Tullberg, Carsten Wikkelsø, Göran Starck
In idiopathic normal pressure hydrocephalus (iNPH), the cerebral blood flow (CBF) is of pathophysiological interest and a potential biomarker. Computed tomography perfusion (CTP), an established technique with high spatial resolution and quantitative measurements, has not yet been used in the iNPH context. If CTP were sensitive to the CBF levels and changes in iNPH, this technique might provide diagnostic and prognostic absolute perfusion thresholds. The aim of this work was to determine the applicability of CTP to iNPH...
October 14, 2015: Journal of Cerebral Blood Flow and Metabolism
Hai Yu, Min Yang, Xiaobo Zhan, Yu Zhu, Jian Shen, Renya Zhan
OBJECTIVE: The aim of this study was to analyse the shunt placement in patients who had normal pressure hydrocephalus after poor-grade aneurysmal subarachnoid haemorrhage (aSAH). METHODS: Patients diagnosed with NPH after poor-grade aSAH were divided into a treatment group and control group, based on whether they had received ventriculoperitoneal shunt placement. The treatment group was then divided into an improvement group and non-improvement group according to their recovery...
2016: Brain Injury: [BI]
Marcel Levy Nogueira, Stéphane Epelbaum, Jean-Marc Steyaert, Bruno Dubois, Laurent Schwartz
INTRODUCTION: Extracellular accumulation of amyloid-β protein and intracellular accumulation of tau in brain tissues have been described in animal models of Alzheimer's disease (AD) and mechanical stress-based diseases of different mechanisms, such as traumatic brain injury (TBI), arterial hypertension (HTN), and normal pressure hydrocephalus (NPH). METHODS: We provide a brief overview of experimental models of TBI, HTN, and NPH showing features of tau-amyloid pathology, neuroinflammation, and neuronal loss...
March 2016: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
2016-01-02 14:48:03
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