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By İdris Yetimoglu Gynaecologist and obstetrician
Alvaro Danza, Guillermo Ruiz-Irastorza, Munther Khamashta
Antiphospholipid syndrome is characterised by a variety of clinical and immunological manifestations. The clinical hallmarks of this syndrome are thrombosis and poor obstetric outcomes, including miscarriages, fetal loss and severe pre-eclampsia. The main antiphospholipid antibodies include lupus anticoagulant, anticardiolipin and anti-β2-glycoprotein I. The combination of aspirin and heparin is considered the standard of care for women with antiphospholipid syndrome and embryo-fetal losses; however, aspirin in monotherapy may have a place in women with recurrent early miscarriage...
February 2012: Best Practice & Research. Clinical Obstetrics & Gynaecology
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