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Kidney and immunoadsorption

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3 papers 0 to 25 followers
By P O Pediatrics, Nephrology
Madelon van Agteren, Willem Weimar, Annelies E de Weerd, Peter A W Te Boekhorst, Jan N M Ijzermans, Jaqueline van de Wetering, Michiel G H Betjes
This study describes the single center experience and long-term results of ABOi kidney transplantation using a pretransplantation protocol involving immunoadsorption combined with rituximab, intravenous immunoglobulins, and triple immune suppression. Fifty patients received an ABOi kidney transplant in the period from 2006 to 2012 with a follow-up of at least one year. Eleven antibody mediated rejections were noted of which 5 were mixed antibody and cellular mediated rejections. Nine cellular mediated rejections were recorded...
2014: Journal of Transplantation
S├ębastien Maggioni, Asma Allal, Nassim Kamar, Martine Hermelin, Eric Faubel, Lionel Rostaing
PURPOSE: We have designed a desensitization program that gives good results and is cost effective for kidney-transplant patients who have a potential living donor, who are ABO incompatible (ABOi), and who may or may not have donor-specific alloantibodies (DSAs). METHODS: Desensitization at pretransplant is based on immunosuppressants (such as rituximab, tacrolimus, and mycophenolic acid) and apheresis to retrieve potentially detrimental isoagglutinins and DSAs from blood...
June 2015: International Journal of Artificial Organs
Tai Yeon Koo, Jaeseok Yang
ABO-incompatible kidney transplantation (ABOi KT) was introduced to expand the donor pool and minimize shortage of kidneys for transplantation. Because improved outcomes of ABOi KT were reported in Japan in the early 2000s, the number of ABOi KTs has been increasing worldwide. In addition, a better understanding of immune pathogenesis and subsequent aggressive immunosuppression has helped to make effective desensitization protocols. Current strategies of ABOi KT consist of pretransplant antibody removal using plasmapheresis or immunoadsorption to prevent hyperacute rejection and potent maintenance immunosuppression, such as tacrolimus and mycophenolate mofetil, to inhibit antibody-mediated rejection...
September 2015: Kidney Research and Clinical Practice
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