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Breast caner treatment

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23 papers 25 to 100 followers
https://www.readbyqxmd.com/read/26445887/benefits-of-preoperative-mri-in-breast-cancer-surgery-studied-in-a-large-population-based-cancer-registry
#1
MULTICENTER STUDY
E L Vos, A C Voogd, C Verhoef, S Siesling, I M Obdeijn, L B Koppert
BACKGROUND: Although evidence for the benefits of preoperative MRI in breast cancer is lacking, use of MRI is increasing and characterized by large interhospital variation. The aim of the study was to evaluate MRI use and surgical outcomes retrospectively. METHODS: Women with invasive breast cancer (pT1-3) or ductal carcinoma in situ (DCIS), diagnosed in 2011-2013, were selected from the Netherlands Cancer Registry and subdivided into the following groups: invasive cancer, high-grade DCIS, non-palpable cancer, age 40 years or less, and invasive lobular cancer...
December 2015: British Journal of Surgery
https://www.readbyqxmd.com/read/26511429/false-positive-extra-mammary-findings-in-breast-mri-another-cause-for-concern
#2
Shilpa A Padia, Mary Freyvogel, Jill Dietz, Stephanie Valente, Colin O'Rourke, Stephen R Grobmyer
Breast magnetic resonance imaging (MRI) has been repeatedly shown to have a high false-positive rate for additional findings in the breast resulting in additional breast imaging and biopsies. We hypothesize that breast MRI is also associated with a high rate of false-positive findings outside of the breast requiring additional evaluation, interventions, and delays in treatment. We performed a retrospective review of all breast MRIs performed on breast cancer patients in 2010 at a single institution. MRI reports were analyzed for extra-mammary findings...
January 2016: Breast Journal
https://www.readbyqxmd.com/read/26545845/inflammatory-breast-cancer-unique-biological-and-therapeutic-considerations
#3
Wendy A Woodward
Through the concerted efforts of many patients, health-care providers, legislators, and other supporters, the past decade has seen the development of the first clinics dedicated to the care of patients with inflammatory breast cancer in the USA and other countries. Together with social networking, advocacy, and education, a few specialised centres have had substantial increases in patient numbers (in some cases ten times higher), which has further expanded the community of science and advocacy and increased the understanding of the disease process...
November 2015: Lancet Oncology
https://www.readbyqxmd.com/read/26567364/how-do-cytotoxic-lymphocytes-kill-cancer-cells
#4
REVIEW
Luis Martínez-Lostao, Alberto Anel, Julián Pardo
In the past few years, cancer immunotherapy has emerged as a safe and effective alternative for treatment of cancers that do not respond to classical treatments, including those types with high aggressiveness. New immune modulators, such as cytokines, blockers of CTLA-4 (cytotoxic T-lymphocyte-associated protein 4) and PD-1(programmed cell death protein 1)/PD-L1 (programmed death-ligand 1), and interaction or adoptive cell therapy, have been developed and approved to treat solid and hematologic carcinomas. In these scenarios, cytotoxic lymphocytes (CL), mainly cytotoxic T cells (Tc) and natural killer (NK) cells, are ultimately responsible for killing the cancer cells and eradicating the tumor...
November 15, 2015: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/26412350/biology-before-anatomy-in-early-breast-cancer-precisely-the-point
#5
EDITORIAL
Clifford A Hudis
No abstract text is available yet for this article.
November 19, 2015: New England Journal of Medicine
https://www.readbyqxmd.com/read/26400157/axillary-ultrasound-in-the-management-of-the-newly-diagnosed-breast-cancer-patient
#6
REVIEW
Zahraa Al-Hilli, Tina J Hieken, Judy C Boughey
Axillary lymph node status remains an important prognostic factor in patients with breast cancer. Axillary ultrasound (AUS) is an important tool in the workup of patients with newly diagnosed breast cancer and also has an emerging role evaluating the axilla after neoadjuvant chemotherapy. This review discusses the value of AUS in the workup and management of patients with newly diagnosed breast cancer and describes its role given the recent changes in axillary management.
November 2015: Breast Journal
https://www.readbyqxmd.com/read/26515410/incidence-and-treatment-patterns-of-complicated-bone-metastases-in-a-population-based-radiotherapy-program
#7
Manpreet S Tiwana, Mark Barnes, Emily Yurkowski, Kelsey Roden, Robert A Olson
INTRODUCTION: There is abundant evidence in support of single fraction (SF) radiation therapy (RT) for uncomplicated bone metastases (BoM). We sought to determine the proportion of BoM that is complicated in a population-based RT program in order to act as a potential guide for assessing SFRT utilization rates. MATERIALS AND METHODS: A total of 3200 RT courses were prescribed to 1880 consecutive patients diagnosed with BoM in 2013. Associations between choice of RT fractionation and BoM characterization, whether complicated or not, were assessed with logistic regression...
March 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/26429646/management-of-internal-mammary-nodes-in-early-stage-breast-cancer-response-to-comments-by-de-cicco-et-al
#8
LETTER
David Vrana, Lucie Lukesova, Jiri Gatek, Bohuslav Melichar, Zuzana Vlachova
No abstract text is available yet for this article.
January 2016: Tumori
https://www.readbyqxmd.com/read/26435108/fighting-breast-cancer-better-detection-and-better-therapy-make-for-a-strong-one-two-punch-in-the-fight-against-breast-cancer
#9
EDITORIAL
Bibb Allen
No abstract text is available yet for this article.
October 2015: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/26443566/with-better-adjuvant-therapy-does-breast-cancer-stage-still-matter
#10
EDITORIAL
Ines Vaz-Luis, Harold J Burstein
No abstract text is available yet for this article.
2015: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/26446851/treatment-of-multifocal-breast-cancer-by-systemic-delivery-of-dual-targeted-adeno-associated-viral-vectors
#11
M Trepel, J Körbelin, E Spies, M B Heckmann, A Hunger, B Fehse, H A Katus, J A Kleinschmidt, O J Müller, S Michelfelder
No abstract text is available yet for this article.
October 2015: Gene Therapy
https://www.readbyqxmd.com/read/26467471/guidelines-for-time-to-event-end-point-definitions-in-breast-cancer-trials-results-of-the-datecan-initiative-definition-for-the-assessment-of-time-to-event-endpoints-in-cancer-trials
#12
S Gourgou-Bourgade, D Cameron, P Poortmans, B Asselain, D Azria, F Cardoso, R A'Hern, J Bliss, J Bogaerts, H Bonnefoi, E Brain, M J Cardoso, B Chibaudel, R Coleman, T Cufer, L Dal Lago, F Dalenc, E De Azambuja, M Debled, S Delaloge, T Filleron, J Gligorov, M Gutowski, W Jacot, C Kirkove, G MacGrogan, S Michiels, I Negreiros, B V Offersen, F Penault Llorca, G Pruneri, H Roche, N S Russell, F Schmitt, V Servent, B Thürlimann, M Untch, J A van der Hage, G van Tienhoven, H Wildiers, J Yarnold, F Bonnetain, S Mathoulin-Pélissier, C Bellera, T S Dabakuyo-Yonli
No abstract text is available yet for this article.
December 2015: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/26481807/preoperative-mri-in-breast-cancer
#13
Talha Khan Burki
No abstract text is available yet for this article.
November 2015: Lancet Oncology
https://www.readbyqxmd.com/read/26420778/the-effectiveness-of-group-intervention-on-enhancing-cognitive-emotion-regulation-strategies-in-breast-cancer-patients-a-2-year-follow-up
#14
Yaira Hamama-Raz, Ruth Pat-Horenczyk, Shlomit Perry, Yuval Ziv, Ruth Bar-Levav, Salomon M Stemmer
Purpose To evaluate the long-term effect of group intervention on enhancing cognitive emotion regulation (CER) strategies in female patients with early-stage breast cancer. Methods The sample included 174 patients who were diagnosed with early-to-mid stage breast cancer, completed adjuvant therapy, and agreed to fill out demographic and cognitive emotion regulation questionnaires (CERQ). About half of the patients (86, 49.4%) chose to participate in an 8-session group intervention (intervention group) while the others (88, 50...
June 2016: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/26503920/palliative-care-problem-severity-score-reliability-and-acceptability-in-a-national-study
#15
Malcolm Masso, Samuel Frederic Allingham, Claire Elizabeth Johnson, Tanya Pidgeon, Patsy Yates, David Currow, Kathy Eagar
BACKGROUND: The Palliative Care Problem Severity Score is a clinician-rated tool to assess problem severity in four palliative care domains (pain, other symptoms, psychological/spiritual, family/carer problems) using a 4-point categorical scale (absent, mild, moderate, severe). AIM: To test the reliability and acceptability of the Palliative Care Problem Severity Score. DESIGN: Multi-centre, cross-sectional study involving pairs of clinicians independently rating problem severity using the tool...
May 2016: Palliative Medicine
https://www.readbyqxmd.com/read/26465826/toward-evidence-based-end-of-life-care
#16
Scott D Halpern
The disquieting patterns of end-of-life care in the United States have been well documented. In the last month of life, one in two Medicare beneficiaries visits an emergency department, one in three is admitted to an intensive care unit, and one in five has inpatient surgery. But one of the most..
November 19, 2015: New England Journal of Medicine
https://www.readbyqxmd.com/read/26464809/immune-profiling-in-human-breast-cancer-using-high-sensitivity-detection-and-analysis-techniques
#17
Brendon J Coventry, Michael J Weightman, John Bradley, John M Skinner
OBJECTIVES: Evaluation of immune profiles in human breast cancer using high-sensitivity detection and analysis methods. DESIGN: Cohort comparative analysis studies of breast tissue. SETTING: Human hospital and laboratory healthcare facilities. PARTICIPANTS: Women over 18 years. MAIN OUTCOME MEASURES: Evaluation of the comparative immunophenotype of human breast carcinoma and normal breast tissues...
September 2015: JRSM Open
https://www.readbyqxmd.com/read/26394558/the-importance-of-surgical-margins-in-breast-cancer
#18
REVIEW
Colleen M O'Kelly Priddy, Victoria A Forte, Julie E Lang
Achieving negative margins with "no tumor on ink" is an appropriate goal in breast conserving therapy (BCT). Wider margins do not decrease recurrence rates, and re-excision in patients with microscopic positive margins is warranted. Several strategies exist to increase rates of negative margins, including techniques to improve tumor localization, intraoperative assessment of margins and oncoplastic techniques. Negative margins should be the goal of BCT, as this will improve both local control and long-term survival...
March 2016: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/26454681/fractionation-of-palliative-radiation-therapy-for-bone-metastases-in-ontario-do-practice-guidelines-guide-practice
#19
Allison Ashworth, Weidong Kong, Edward Chow, William J Mackillop
PURPOSE: To evaluate the effect of a provincial practice guideline on the fractionation of palliative radiation therapy for bone metastases (PRT.B) in Ontario. METHODS AND MATERIALS: The present retrospective study used electronic treatment records linked to Ontario's population-based cancer registry. Hierarchical multivariable regression analysis was used to evaluate temporal trends in the use of single fractions (SFs), controlling for patient-related factors associated with the use of SFs...
January 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/26486999/intraoperative-ultrasound-guidance-in-breast-conserving-surgery-improves-cosmetic-outcomes-and-patient-satisfaction-results-of-a-multicenter-randomized-controlled-trial-cobalt
#20
RANDOMIZED CONTROLLED TRIAL
Max H Haloua, José H Volders, Nicole M A Krekel, Alexander M F Lopes Cardozo, Wifred K de Roos, Louise M de Widt-Levert, Henk van der Veen, Herman Rijna, Elisabeth Bergers, Katarzyna Jóźwiak, Sybren Meijer, Petrousjka van den Tol
BACKGROUND: Ultrasound-guided breast-conserving surgery (USS) results in a significant reduction in both margin involvement and excision volumes (COBALT trial). Objective. The aim of the present study was to determine whether USS also leads to improvements in cosmetic outcome and patient satisfaction when compared with standard palpation-guided surgery (PGS). METHODS: A total of 134 patients with T1–T2 invasive breast cancer were included in the COBALT trial (NTR2579) and randomized to either USS (65 patients) or PGS (69 patients)...
January 2016: Annals of Surgical Oncology
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