N Scott Adzick, Elizabeth A Thom, Catherine Y Spong, John W Brock, Pamela K Burrows, Mark P Johnson, Lori J Howell, Jody A Farrell, Mary E Dabrowiak, Leslie N Sutton, Nalin Gupta, Noel B Tulipan, Mary E D'Alton, Diana L Farmer
BACKGROUND: Prenatal repair of myelomeningocele, the most common form of spina bifida, may result in better neurologic function than repair deferred until after delivery. We compared outcomes of in utero repair with standard postnatal repair. METHODS: We randomly assigned eligible women to undergo either prenatal surgery before 26 weeks of gestation or standard postnatal repair. One primary outcome was a composite of fetal or neonatal death or the need for placement of a cerebrospinal fluid shunt by the age of 12 months...
March 17, 2011: New England Journal of Medicine