Mary C Vance, Eric Bui, Susanne S Hoeppner, Benjamin Kovachy, Jennifer Prescott, David Mischoulon, Zandra E Walton, Melissa Dong, Mireya F Nadal, John J Worthington, Elizabeth A Hoge, Paolo Cassano, Esther H Orr, Maurizio Fava, Immaculata de Vivo, Kwok-Kin Wong, Naomi M Simon
BACKGROUND: Reduced leukocyte telomere length (LTL) has been found to be associated with multiple common age-related diseases, including heart disease, diabetes, and cancer. A link has also been suggested between shortened LTL and major depressive disorder (MDD), suggesting that MDD may be a disease of accelerated aging. This prospective, longitudinal study examined the association between depression diagnosis at baseline and change in LTL over two years in a well-characterized sample of N = 117 adults with or without MDD at baseline, using rigorous entry criteria...
April 2018: Psychoneuroendocrinology