Clímaco Andres Jiménez-Triana, Osvaldo D Castelán-Martínez, Rodolfo Rivas-Ruiz, Ricardo Jiménez-Méndez, Aurora Medina, Patricia Clark, Rod Rassekh, Gilberto Castañeda-Hernández, Bruce Carleton, Mara Medeiros
Cisplatin, a major antineoplastic drug used in the treatment of solid tumors, is a known nephrotoxin. This retrospective cohort study evaluated the prevalence and severity of cisplatin nephrotoxicity in 54 children and its impact on height and weight.We recorded the weight, height, serum creatinine, and electrolytes in each cisplatin cycle and after 12 months of treatment. Nephrotoxicity was graded as follows: normal renal function (Grade 0); asymptomatic electrolyte disorders, including an increase in serum creatinine, up to 1...
August 2015: Medicine (Baltimore)