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Chemotherapy-related nephrotoxicity

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3 papers 0 to 25 followers
By P O Pediatrics, Nephrology
Małgorzata Janeczko, Ewa Niedzielska, Wojciech Pietras
BACKGROUND: Wilms' tumor is the most common kidney cancer in children. Treatment consists of pre- and post-operative chemotherapy, surgery and in some cases radiotherapy. The treatment of nephroblastomas is very effective. Hence, the population of adult patients cured of this cancer in their childhood is steadily growing, generating a need for long-term health assessment, including renal function, due to the specifications of the therapy and the location of the tumor. OBJECTIVES: The aim of the study was to evaluate nephrological complications after treatment for nephroblastoma...
May 2015: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Clímaco Andres Jiménez-Triana, Osvaldo D Castelán-Martínez, Rodolfo Rivas-Ruiz, Ricardo Jiménez-Méndez, Aurora Medina, Patricia Clark, Rod Rassekh, Gilberto Castañeda-Hernández, Bruce Carleton, Mara Medeiros
Cisplatin, a major antineoplastic drug used in the treatment of solid tumors, is a known nephrotoxin. This retrospective cohort study evaluated the prevalence and severity of cisplatin nephrotoxicity in 54 children and its impact on height and weight.We recorded the weight, height, serum creatinine, and electrolytes in each cisplatin cycle and after 12 months of treatment. Nephrotoxicity was graded as follows: normal renal function (Grade 0); asymptomatic electrolyte disorders, including an increase in serum creatinine, up to 1...
August 2015: Medicine (Baltimore)
Shreeram Akilesh, Noemie Juaire, Jeremy S Duffield, Kelly D Smith
Ifosfamide is a nitrogen mustard alkylating agent used as both a first-line and a salvage chemotherapeutic agent in the treatment of testicular germ cell tumors, various sarcomas, carcinomas, and some lymphomas. A well-known complication of ifosfamide therapy is transient acute kidney injury. However, in a minority of patients, the reduction in kidney function is progressive and permanent, sometimes occurring long after exposure to ifosfamide. Scattered reports have described the pathologic findings in kidneys permanently affected by ifosfamide toxicity...
May 2014: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
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