Felipe Martinez, Jonathan H Chung, Subba R Digumarthy, Jeffrey P Kanne, Gerald F Abbott, Jo-Anne O Shepard, Eugene J Mark, Amita Sharma
Wegener granulomatosis is an uncommon necrotizing vasculitis that classically manifests as a clinical triad consisting of upper and lower airway involvement and glomerulonephritis. Other less frequently involved organ systems include the central and peripheral nervous system and large joints. The diagnosis is based on a combination of clinical and laboratory findings. Because thoracic involvement often predominates, chest radiographic findings are often the first to suggest the diagnosis. However, chest computed tomography (CT) has superior sensitivity and specificity for evaluation of the airways, lung parenchyma, and mediastinum, particularly with the use of multiplanar reformatted and three-dimensional images...
January 2012: Radiographics: a Review Publication of the Radiological Society of North America, Inc