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Genecept: ParuchMD

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5 papers 0 to 25 followers Additional studies pertaining to Genomind's Genecept assay: http://genomind.com/the-science-behind-the-test/ ParuchMD
By John Paruch Combined training in Internal Medicine-Psychiatry with holistic, evidence-based, preventive approach to implementation and promotion of wellness.
https://www.readbyqxmd.com/read/26888414/physical-and-verbal-aggressive-behavior-and-comt-genotype-sensitivity-to-the-environment
#1
Catherine Tuvblad, Jurgita Narusyte, Erika Comasco, Henrik Andershed, Anna-Karin Andershed, Olivier F Colins, Kostas A Fanti, Kent W Nilsson
Catechol-O-methyltransferase (COMT) genotype has been implicated as a vulnerability factor for several psychiatric diseases as well as aggressive behavior, either directly, or in interaction with an adverse environment. The present study aimed at investigating the susceptibility properties of COMT genotype to adverse and favorable environment in relation to physical and verbal aggressive behavior. The COMT Val158Met polymorphism was genotyped in a Swedish population-based cohort including 1,783 individuals, ages 20-24 years (47% males)...
July 2016: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/24888672/temperament-and-character-in-remitted-and-symptomatic-patients-with-schizophrenia-modulation-by-the-comt-val158met-genotype
#2
Hiroaki Hori, Takashi Fujii, Noriko Yamamoto, Toshiya Teraishi, Miho Ota, Junko Matsuo, Yukiko Kinoshita, Ikki Ishida, Kotaro Hattori, Mitsutoshi Okazaki, Kunimasa Arima, Hiroshi Kunugi
While research on remission in schizophrenia has gained attention, personality characteristics associated with remission in schizophrenia have been under-studied. A functional valine-to-methionine (Val158Met) polymorphism in the catechol-O-methyltransferase (COMT) gene is shown to modify clinical presentation of schizophrenia despite weak or no association with the disorder itself. Studies also report that this polymorphism can affect personality traits. We aimed to examine personality traits of remitted patients with schizophrenia as compared to symptomatic patients and healthy controls and to investigate whether the COMT Val158Met polymorphism influences their personality...
September 2014: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/22843413/the-catechol-o-methyltransferase-val-158-met-polymorphism-modulates-fronto-cortical-dopamine-turnover-in-early-parkinson-s-disease-a-pet-study
#3
Kit Wu, Deirdre O'Keeffe, Marios Politis, Grainne C O'Keeffe, Trevor W Robbins, Subrata K Bose, David J Brooks, Paola Piccini, Roger A Barker
Cognitive deficits occur in up to 30% of patients with early Parkinson's disease, some of which are thought to result from dysfunction within the fronto-striatal dopaminergic network. Recently, it has been shown that a common functional polymorphism (Val(158)Met) in the catechol-O-methyltransferase (COMT) gene is associated with changes in executive performance in tasks that have a fronto-striatal basis. This is thought to relate to changes in cortical dopamine levels as catechol-O-methyltransferase is the main mode of inactivation for dopamine in frontal areas...
August 2012: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/22528689/pain-sensitivity-in-fibromyalgia-is-associated-with-catechol-o-methyltransferase-comt-gene
#4
M Martínez-Jauand, C Sitges, V Rodríguez, A Picornell, M Ramon, D Buskila, P Montoya
BACKGROUND: Recent evidence suggests that genetic factors might contribute to individual differences in pain sensitivity, risk for developing clinical pain conditions and efficacy of pain treatments. The purpose of the present study was to investigate the relationship of three common haplotypes of COMT gene affecting the metabolism of catecholamines on pain sensitivity in patients with fibromyalgia (FM). METHODS: One hundred and thirteen FM patients and 65 age-matched healthy volunteers participated in the study...
January 2013: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/21280081/the-comt-val158met-polymorphism-affects-the-response-to-entacapone-in-parkinson-s-disease-a-randomized-crossover-clinical-trial
#5
RANDOMIZED CONTROLLED TRIAL
Jean-Christophe Corvol, Cécilia Bonnet, Fanny Charbonnier-Beaupel, Anne-Marie Bonnet, Marie-Hélène Fiévet, Agnès Bellanger, Emmanuel Roze, Gayané Meliksetyan, Mouna Ben Djebara, Andreas Hartmann, Lucette Lacomblez, Cédric Vrignaud, Noël Zahr, Yves Agid, Jean Costentin, Jean-Sébastien Hulot, Marie Vidailhet
OBJECTIVE: In Parkinson disease (PD), the selective C-O-methyltransferase (COMT) inhibitor entacapone prolongs the effect of levodopa on motor symptoms (ON time) by increasing its bioavailability. The COMT Val158Met polymorphism is equally distributed in PD patients and modulates COMT activity, which can be high (Val/Val, COMT(HH) ), intermediate (Val/Met, COMT(HL) ), or low (Met/Met, COMT(LL) ). The objective of this study was to determine the response to entacapone in COMT(HH) and COMT(LL) PD patients...
January 2011: Annals of Neurology
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