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Neuropathic Pain literature

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95 papers 100 to 500 followers
By Andreas Tarnaris Consultant Neurosurgeon
https://www.readbyqxmd.com/read/29702086/melatonin-decreases-neuronal-excitability-in-a-sub-population-of-dorsal-root-ganglion-neurons
#1
Klausen Oliveira-Abreu, Francisco Walber Ferreira-da-Silva, Kerly Shamyra da Silva-Alves, Nathalia Maria Silva-Dos-Santos, Ana Carolina Cardoso-Teixeira, Fernanda Gaspar do Amaral, José Cipolla-Neto, José Henrique Leal-Cardoso
Melatonin, a powerful antioxidant, participates in the regulation of important physiological and pathological processes. We investigated the actions of melatonin on neuronal excitability of intact dorsal root ganglions (DRG) from rats using intracellular recording techniques in current clamps. Melatonin blocked the generation of action potentials in a concentration-dependent manner. Bath applied melatonin (1.0-1000.0 nM) hyperpolarized the resting membrane potential, and increased the input resistance and rheobase...
April 24, 2018: Brain Research
https://www.readbyqxmd.com/read/29674264/ultrasonic-modulation-of-neural-circuit-activity
#2
REVIEW
William J Tyler, Shane W Lani, Grace M Hwang
Ultrasound (US) is recognized for its use in medical imaging as a diagnostic tool. As an acoustic energy source, US has become increasingly appreciated over the past decade for its ability to non-invasively modulate cellular activity including neuronal activity. Data obtained from a host of experimental models has shown that low-intensity US can reversibly modulate the physiological activity of neurons in peripheral nerves, spinal cord, and intact brain circuits. Experimental evidence indicates that acoustic pressures exerted by US act, in part, on mechanosensitive ion channels to modulate activity...
April 16, 2018: Current Opinion in Neurobiology
https://www.readbyqxmd.com/read/29699887/repetitive-transcranial-magnetic-stimulation-accuracy-as-a-spinal-cord-stimulation-outcome-predictor-in-patients-with-neuropathic-pain
#3
Takeshi Shimizu, Koichi Hosomi, Tomoyuki Maruo, Yuko Goto, Toshio Shimokawa, Kishima Haruhiko, Youichi Saitoh
OBJECT: Spinal cord stimulation (SCS) is an effective albeit invasive and relatively expensive treatment of neuropathic pain. Repetitive transcranial magnetic stimulation (rTMS) over the primary motor cortex (M1) is a non-invasive treatment of neuropathic pain. The aim of the current study was to investigate whether rTMS can predict the successful outcome of SCS. METHODS: The study population consisted of 22 patients with neuropathic pain who had undergone SCS and rTMS...
April 23, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29526043/spinal-cord-stimulation-clinical-efficacy-and-potential-mechanisms
#4
REVIEW
Andrei D Sdrulla, Yun Guan, Srinivasa N Raja
Spinal cord stimulation (SCS) is a minimally invasive therapy used for the treatment of chronic neuropathic pain. SCS is a safe and effective alternative to medications such as opioids, and multiple randomized controlled studies have demonstrated efficacy for difficult-to-treat neuropathic conditions such as failed back surgery syndrome. Conventional SCS is believed mediate pain relief via activation of dorsal column Aβ fibers, resulting in variable effects on sensory and pain thresholds, and measurable alterations in higher order cortical processing...
March 11, 2018: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/29565946/anatomy-pathophysiology-and-interventional-therapies-for-chronic-pelvic-pain-a-review
#5
Corey W Hunter, Brad Stovall, Grant Chen, Jonathan Carlson, Robert Levy
BACKGROUND: Chronic pelvic pain (CPP) represents a group of poorly understood disorders that are often refractory to conventional treatment. Referral to pain management typically occurs later in the continuum of care; as such, many of the injections and nerve blocks commonly prescribed for such patients are potentially limited in efficacy. While neuromodulation is conventionally considered the next algorithmic step in the treatment of chronic pain after injections fail, there is a common perception that neuromodulation is largely ineffective for CPP conditions...
March 2018: Pain Physician
https://www.readbyqxmd.com/read/29608974/pain-neuroimaging-in-humans-a-primer-for-beginners-and-non-imagers
#6
Massieh Moayedi, Tim V Salomons, Lauren Y Atlas
The field of human pain neuroimaging has exploded in the last two decades. During this time, the broader neuroimaging community has continued to investigate and refine methods. Another key to progress is exchange with clinicians and pain scientists working with other model systems and approaches. These collaborative efforts require that non-imagers be able to evaluate and assess the evidence provided in these papers. Likewise, new trainees must design rigorous and reliable pain imaging experiments. Here, we provide a guideline for designing, reading, evaluating, analyzing, and reporting results of a pain neuroimaging experiment, with a focus on functional and structural MRI...
March 30, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29538696/spinal-cord-stimulation-for-the-treatment-of-chronic-pain-reduces-opioid-use-and-results-in-superior-clinical-outcomes-when-used-without-opioids
#7
Lucy Gee, Heather C Smith, Zohal Ghulam-Jelani, Hirah Khan, Julia Prusik, Paul J Feustel, Sarah E McCallum, Julie G Pilitsis
BACKGROUND: Chronic pain causes a significant burden to the US health care system, is difficult to treat, and remains a significant contributor to increased opioid use in the United States. Spinal cord stimulation (SCS) has been FDA approved for the treatment of chronic pain. OBJECTIVE: To evaluate the hypothesis that SCS reduces opioid use, and alone maintains clinical outcome measures of pain and psychosocial determinants of health. METHODS: In this prospective cohort study, we evaluated 86 patients undergoing SCS surgery for the treatment of chronic pain between September 2012 and August 2015...
March 12, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29226044/neuroanatomy-and-neuropsychology-of-pain
#8
REVIEW
Shehzad Khalid, R Shane Tubbs
We have reviewed here the neuroanatomical and neuropsychological literature of the human brain and have proposed the various pain mechanisms that we currently know of. Essentially when tissue is damaged, peripheral nociceptors are activated continuously and prostanoids are hence produced. Nonsteroidal anti-inflammatory drugs (NSAIDs) and medications aim to target these prostanoids to treat the inflammatory component of pain. Normal pain tends to have a protective response. It is important for the nervous system to learn and recognize this painful stimulus earlier and quicker with repeated exposure to avoid tissue damage...
October 6, 2017: Curēus
https://www.readbyqxmd.com/read/29516437/therapeutic-approaches-for-the-management-of-trigeminal-autonomic-cephalalgias
#9
REVIEW
Diana Y Wei, Rigmor H Jensen
Trigeminal autonomic cephalalgia (TAC) encompasses 4 unique primary headache types: cluster headache, paroxysmal hemicrania, hemicrania continua, and short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing and short-lasting unilateral neuralgiform headache attacks with cranial autonomic symptoms. They are grouped on the basis of their shared clinical features of unilateral headache of varying durations and ipsilateral cranial autonomic symptoms. The shared clinical features reflect the underlying activation of the trigeminal-autonomic reflex...
April 2018: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/29556828/treatment-of-the-patient-with-refractory-headache
#10
REVIEW
Alessandro S Zagami
PURPOSE OF REVIEW: To review recent studies outlining the management of refractory primary headache patients, including emerging therapies such as neuromodulation. This includes both noninvasive and invasive neuromodulation techniques. Recent studies on the management of medication overuse headache were also reviewed. RECENT FINDINGS: There is no consensus as yet on the definitions of refractory chronic migraine and chronic cluster headache although there is broad agreement on some aspects of these terms...
March 19, 2018: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/29556851/novel-interventional-nonopioid-therapies-in-headache-management
#11
REVIEW
Omar Viswanath, Roxanna Rasekhi, Rekhaben Suthar, Mark R Jones, Jacquelin Peck, Alan D Kaye
PURPOSE OF REVIEW: Headaches encompass a broad-based category of a symptom of pain in the region of the head or neck. For those patients who unfortunately do not obtain relief from conservative treatment, interventional techniques have been developed and are continuing to be refined in an attempt to treat this subset of patients with the goal of return of daily activities. This investigation reviews various categories of headaches, their pathophysiology, and types of interventional treatments currently available...
March 19, 2018: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/29688562/stereotactic-radiosurgery-for-trigeminal-neuralgia-in-patients-with-multiple-sclerosis-a-multicenter-study
#12
Zhiyuan Xu, David Mathieu, France Heroux, Mahmoud Abbassy, Gene Barnett, Alireza M Mohammadi, Hideyuki Kano, James Caruso, Han-Hsun Shih, Inga S Grills, Kuei Lee, Sandeep Krishnan, Anthony M Kaufmann, John Y K Lee, Michelle Alonso-Basanta, Marie Kerr, John Pierce, Douglas Kondziolka, Judith A Hess, Jason Gerrard, Veronica Chiang, L Dade Lunsford, Jason P Sheehan
BACKGROUND: Facial pain response (PR) to various surgical interventions in patients with multiple sclerosis (MS)-related trigeminal neuralgia (TN) is much less optimal. No large patient series regarding stereotactic radiosurgery (SRS) has been published. OBJECTIVE: To evaluate the clinical outcomes of MS-related TN treated with SRS. METHODS: This is a retrospective cohort study. A total of 263 patients contributed by 9 member tertiary referral Gamma Knife centers (2 in Canada and 7 in USA) of the International Gamma Knife Research Consortium (IGKRF) constituted this study...
April 23, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29694464/effects-of-a-physical-therapy-protocol-in-patients-with-chronic-migraine-and-temporomandibular-disorders-a-randomized-single-blinded-clinical-trial
#13
Miriam Garrigós-Pedrón, Roy La Touche, Pablo Navarro-Desentre, Manuel Gracia-Naya, Eva Segura-Ortí
AIMS: To investigate the effects of adding orofacial treatment to cervical physical therapy in patients with chronic migraine and temporomandibular disorders (TMD). METHODS: A total of 45 participants with chronic migraine and TMD aged 18 to 65 years were randomized into two groups: a cervical group (CG) and a cervical and orofacial group (COG). Both groups continued their medication regimens for migraine treatment and received physical therapy. The CG received physical therapy only in the cervical region, and the COG received physical therapy in both the cervical and orofacial regions...
April 2018: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/29500312/etiology-and-pharmacology-of-neuropathic-pain
#14
REVIEW
Sascha R A Alles, Peter A Smith
Injury to or disease of the nervous system can invoke chronic and sometimes intractable neuropathic pain. Many parallel, interdependent, and time-dependent processes, including neuroimmune interactions at the peripheral, supraspinal, and spinal levels, contribute to the etiology of this "disease of pain." Recent work emphasizes the roles of colony-stimulating factor 1, ATP, and brain-derived neurotrophic factor. Excitatory processes are enhanced, and inhibitory processes are attenuated in the spinal dorsal horn and throughout the somatosensory system...
April 2018: Pharmacological Reviews
https://www.readbyqxmd.com/read/29149156/survival-analysis-of-occipital-nerve-stimulator-leads-placed-under-fluoroscopic-guidance-with-and-without-ultrasonography
#15
James H Jones, Alison Brown, Daniel Moyse, Wenjing Qi, Lance Roy
BACKGROUND: Electrical stimulation of the greater occipital nerves is performed to treat pain secondary to chronic daily headaches and occipital neuralgia. The use of fluoroscopy alone to guide the surgical placement of electrodes near the greater occipital nerves disregards the impact of tissue planes on lead stability and stimulation efficacy. OBJECTIVE: We hypothesized that occipital neurostimulator (ONS) leads placed with ultrasonography combined with fluoroscopy would demonstrate increased survival rates and times when compared to ONS leads placed with fluoroscopy alone...
November 2017: Pain Physician
https://www.readbyqxmd.com/read/29345415/investigating-complications-associated-with-occipital-nerve-stimulation-a-maude-study
#16
REVIEW
Joseph Doran, Max Ward, Brittany Ward, Boris Paskhover, Michael Umanoff, Antonios Mammis
OBJECTIVES: The objectives of this study are to utilize the MAUDE data base to enhance our understanding of the complication profile for Occipital Nerve Stimulation, a therapy for which the current level of evidence is limited. Additionally, it is our objective to describe a systematic approach to processing the MAUDE data, which addresses its flaws and enhances its utility. METHODS: From the FDA website, we accessed adverse events reports from the MAUDE data base for devices used in Occipital Nerve Stimulation between June 30, 2007 and June 30, 2017...
January 18, 2018: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29480963/treatment-of-refractory-idiopathic-supraorbital-neuralgia-using-percutaneous-pulsed-radiofrequency
#17
Fang Luo, Jingjing Lu, Nan Ji
BACKGROUND AND AIMS: No ideal therapeutic method currently exists for refractory idiopathic supraorbital neuralgia patients who do not respond to conservative therapy, including medications and nerve blocks. Pulsed radiofrequency is a neuromodulation technique that does not produce sequelae of nerve damage after treatment. However, the efficacy of percutaneous pulsed radiofrequency for the treatment of refractory idiopathic supraorbital neuralgia is still not clear. The purpose of our study was to evaluate the efficacy and safety of pulsed radiofrequency treatment of the supraorbital nerve for refractory supraorbital neuralgia patients...
February 26, 2018: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/29199767/oxcarbazepine-for-neuropathic-pain
#18
REVIEW
Muke Zhou, Ning Chen, Li He, Mi Yang, Cairong Zhu, Fengbo Wu
BACKGROUND: Several anticonvulsant drugs are used in the management of neuropathic pain. Oxcarbazepine is an anticonvulsant drug closely related to carbamazepine. Oxcarbazepine has been reported to be efficacious in the treatment of neuropathic pain, but evidence from randomised controlled trials (RCTs) is conflicting. Oxcarbazepine is reportedly better tolerated than carbamazepine. This is the first update of a review published in 2013. OBJECTIVES: To assess the benefits and harms of oxcarbazepine for different types of neuropathic pain...
December 2, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29377062/adverse-effects-of-anti-epileptics-in-trigeminal-neuralgiform-pain
#19
V Tentolouris-Piperas, G Lee, J Reading, A G O'Keeffe, J M Zakrzewska, R Cregg
BACKGROUND: Side effects of anti-epileptic drugs (AEDs) have not been adequately documented in trigeminal neuralgia and its variants. The aim of this observational cross-sectional study was to compare the A-B Neuropsychological Assessment Schedule (ABNAS), which measures cognitive side effects to the Adverse Events Profile (AEP), which looks at a broader range of side effects, and to investigate drug/dosage relationships with questionnaire scores to help determine a point at which a drug change would be indicated...
January 28, 2018: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29382615/pain-free-outcomes-and-durability-of-surgical-intervention-for-trigeminal-neuralgia-a-comparison-of-gamma-knife-and-microvascular-decompression
#20
Zachary S Mendelson, Jayant R Velagala, Gurkirat Kohli, Gary M Heir, Antonios Mammis, James K Liu
OBJECTIVE: Treatment options for trigeminal neuralgia include microvascular decompression (MVD) and Gamma Knife surgery (GKS). There is no consensus which option is more effective at providing immediate and long-lasting pain relief. This study evaluated the differences between these 2 options in terms of rates of complete pain relief and pain-free recurrence. METHODS: A systematic review was conducted of published studies of MVD and GKS for treatment of trigeminal neuralgia from 2004 to 2014...
April 2018: World Neurosurgery
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