Kenneth B Baker, Ela B Plow, Sean Nagel, Anson B Rosenfeldt, Raghavan Gopalakrishnan, Cynthia Clark, Alexandria Wyant, Madeleine Schroedel, John Ozinga, Sara Davidson, Olivia Hogue, Darlene Floden, Jacqueline Chen, Paul J Ford, Lauren Sankary, Xuemei Huang, David A Cunningham, Frank P DiFilippo, Bo Hu, Stephen E Jones, Francois Bethoux, Steven L Wolf, John Chae, André G Machado
Upper-extremity impairment after stroke remains a major therapeutic challenge and a target of neuromodulation treatment efforts. In this open-label, non-randomized phase I trial, we applied deep brain stimulation to the cerebellar dentate nucleus combined with renewed physical rehabilitation to promote functional reorganization of ipsilesional cortex in 12 individuals with persistent (1-3 years), moderate-to-severe upper-extremity impairment. No serious perioperative or stimulation-related adverse events were encountered, with participants demonstrating a seven-point median improvement on the Upper-Extremity Fugl-Meyer Assessment...
August 14, 2023: Nature Medicine