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Deep Brain Stimulation literature

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211 papers 100 to 500 followers
By Andreas Tarnaris Consultant Neurosurgeon
https://www.readbyqxmd.com/read/28869946/stereotactic-radiosurgery-for-intractable-tremor-dominant-parkinson-disease-a-retrospective-analysis
#1
Sudesh S Raju, Ajay Niranjan, Edward A Monaco Iii, John C Flickinger, L Dade Lunsford
OBJECTIVE: The purpose of this study was to retrospectively analyze the outcomes of stereotactic radiosurgery for patients suffering from medically refractory Parkinson disease (PD) tremor. METHODS: We retrospectively studied the outcomes of 33 patients who were treated with gamma knife thalamotomy (GKT) over a 19-year period. Twelve patients were ≥80 years. A median dose of 140 Gy (range, 130-150 Gy) was delivered to the nucleus ventralis intermedius through a single 4-mm isocenter...
September 2, 2017: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/28882161/general-anesthesia-versus-local-anesthesia-in-stereotaxy-galaxy-for-parkinson-s-disease-study-protocol-for-a-randomized-controlled-trial
#2
R A Holewijn, D Verbaan, R M A de Bie, P R Schuurman
BACKGROUND: The aim of the study is to investigate if deep brain stimulation (DBS) in the subthalamic nucleus (STN) for Parkinson's disease (PD) under general anesthesia further improves outcome by lessening postoperative cognitive, mood, and behavioral adverse effects; shorten surgical time and hospital admittance; and produce comparable symptomatic and functional improvement to surgery under local anesthesia. METHODS/DESIGN: The study will be a single-center, prospective, randomized, open-label, blinded endpoint trial comparing DBS under general anesthesia with DBS under local anesthesia...
September 7, 2017: Trials
https://www.readbyqxmd.com/read/28889124/factors-affecting-stereotactic-accuracy-in-image-guided-deep-brain-stimulator-electrode-placement
#3
Andrew L Ko, Aly Ibrahim, Philippe Magown, Rebecca Macallum, Kim J Burchiel
BACKGROUND/AIMS: Intraoperative imaging allows near-real-time assessment of stereotactic accuracy during implantation of deep brain stimulation (DBS) electrodes. Such technology can be used to examine factors impacting stereotactic error. METHODS: Intraoperative CT imaging was reviewed in patients undergoing DBS placement at Oregon Health and Sciences University. Coordinates of the target electrode were compared to the operative plan to characterize the magnitude and direction of stereotactic error with respect to side of implantation, target, and electrode approach angles...
September 9, 2017: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/28889128/hemorrhage-detection-and-incidence-during-magnetic-resonance-guided-deep-brain-stimulator-implantations
#4
Alastair J Martin, Philip A Starr, Jill L Ostrem, Paul S Larson
BACKGROUND/AIMS: Intraoperative magnetic resonance imaging (iMRI) is increasingly used to implant deep brain stimulator (DBS) electrodes. The approach has the advantages of a high targeting accuracy, minimization of brain penetrations, and allowance of implantation under general anesthesia. The hemorrhagic complications of iMRI-guided DBS implantation have not been studied in a large series. We report on the incidence and characteristics of hemorrhage during these procedures. METHODS: Hemorrhage incidence was assessed in a series of 231 iMRI procedures (374 electrodes implanted)...
September 9, 2017: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/28894414/hemodynamic-perturbations-in-deep-brain-stimulation-surgery-first-detailed-description
#5
Tumul Chowdhury, Marshall Wilkinson, Ronald B Cappellani
Background: Hemodynamic perturbations can be anticipated in deep brain stimulation (DBS) surgery and may be attributed to multiple factors. Acute changes in hemodynamics may produce rare but severe complications such as intracranial bleeding, transient ischemic stroke and myocardium infarction. Therefore, this retrospective study attempts to determine the incidence of hemodynamic perturbances (rate) and related risk factors in patients undergoing DBS surgery. Materials and Methods: After institutional approval, all patients undergoing DBS surgery for the past 10 years were recruited for this study...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28901969/disorders-of-consciousness-after-severe-brain-injury-therapeutic-options
#6
Caroline Schnakers, Martin M Monti
PURPOSE OF REVIEW: Very few options exist for patients who survive severe traumatic brain injury but fail to fully recover and develop a disorder of consciousness (e.g. vegetative state, minimally conscious state). RECENT FINDINGS: Among pharmacological approaches, Amantadine has shown the ability to accelerate functional recovery. Although with very low frequency, Zolpidem has shown the ability to improve the level of consciousness transiently and, possibly, also in a sustained fashion...
September 9, 2017: Current Opinion in Neurology
https://www.readbyqxmd.com/read/28903798/what-s-the-twist-twiddler-s-syndrome-in-deep-brain-stimulation
#7
Zane Tymchak, Aleksander Vitali
No abstract text is available yet for this article.
September 14, 2017: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/28902876/postoperative-lead-migration-in-deep-brain-stimulation-surgery-incidence-risk-factors-and-clinical-impact
#8
Takashi Morishita, Justin D Hilliard, Michael S Okun, Dan Neal, Kelsey A Nestor, David Peace, Alden A Hozouri, Mark R Davidson, Francis J Bova, Justin M Sporrer, Genko Oyama, Kelly D Foote
INTRODUCTION: Deep brain stimulation (DBS) is an effective treatment for multiple movement disorders and shows substantial promise for the treatment of some neuropsychiatric and other disorders of brain neurocircuitry. Optimal neuroanatomical lead position is a critical determinant of clinical outcomes in DBS surgery. Lead migration, defined as an unintended post-operative displacement of the DBS lead, has been previously reported. Despite several reports, however, there have been no systematic investigations of this issue...
2017: PloS One
https://www.readbyqxmd.com/read/28913772/weight-gain-after-subthalamic-nucleus-deep-brain-stimulation-in-parkinson-s-disease-is-influenced-by-dyskinesias-reduction-and-electrodes-position
#9
Roberta Balestrino, Damiano Baroncini, Mario Fichera, Carmine Antonio Donofrio, Alberto Franzin, Pietro Mortini, Giancarlo Comi, Maria Antonietta Volontè
Parkinson's disease is a common neurodegenerative disease that can be treated with pharmacological or surgical therapy. Subthalamic nucleus (STN) deep brain stimulation is a commonly used surgical option. A reported side effect of STN-DBS is weight gain: the aim of our study was to find those factors that determine weight gain, through one year-long observation of 32 patients that underwent surgery in our centre. During the follow-up, we considered: anthropometric features, hormonal levels, motor outcome, neuropsychological and quality of life outcomes, therapeutic parameters and electrodes position...
September 14, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28917282/interventional-mri-guided-deep-brain-stimulation-lead-implantation
#10
REVIEW
Philip S Lee, Robert Mark Richardson
Current knowledge of the functional anatomy of the subthalamic nucleus and globus pallidus, discovered through microelectrode recording and postoperative imaging, justifies purely anatomic targeting for deep brain stimulation (DBS). Interventional MRI (iMRI)-DBS is more anatomically accurate than traditional awake procedures and has similar clinical outcomes without increased risk or increased operative times. iMRI lead implantation allows patients to receive DBS therapy who cannot tolerate or do not agree to undergo an awake procedure...
October 2017: Neurosurgery Clinics of North America
https://www.readbyqxmd.com/read/28920562/comparison-of-general-and-local-anesthesia-for-deep-brain-stimulator-insertion-a-systematic-review
#11
Veena Sheshadri, Nathan C Rowland, Jigesh Mehta, Marina Englesakis, Pirjo Manninen, Lashmi Venkatraghavan
BACKGROUND: Subthalamic nucleus deep brain stimulation (STN-DBS) has become a standard treatment for many patients with Parkinson's disease (PD). The reported clinical outcome measures for procedures done under general anesthesia (GA) compared to traditional local anesthetic (LA) technique are quite heterogeneous and difficult to compare. The aim of this systematic review and metaanalysis was to determine whether the clinical outcome after STN-DBS insertion under GA is comparable to that under LA in patients with Parkinson's disease...
September 18, 2017: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/28922169/app-based-bradykinesia-tasks-for-clinic-and-home-assessment-in-parkinson-s-disease-reliability-and-responsiveness
#12
Dustin A Heldman, Enrique Urrea-Mendoza, Lilia C Lovera, David A Schmerler, Xiomara Garcia, Mohammad E Mohammad, Maria Catalina U McFarlane, Joseph P Giuffrida, Alberto J Espay, Hubert H Fernandez
BACKGROUND: Clinical rating of bradykinesia in Parkinson disease (PD) is challenging as it must combine several movement features into a single score. Additionally, in-clinic assessment cannot capture fluctuations throughout the day. OBJECTIVE: To evaluate the reliability and responsiveness of a motion sensor-based tablet app for objective bradykinesia assessment in clinic and at home as compared to clinical ratings. METHODS: Thirty-two PD patients treated with subthalamic deep brain stimulation (DBS) were outfitted with a motion sensor on the index finger of the more affected hand to perform two repetitions of finger-tapping, hand opening-closing, and arm pronation-supination tasks with DBS on and 10, 20, and 30 minutes after turning DBS off...
September 11, 2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/28930542/deep-brain-stimulation-foundations-and-future-trends
#13
David J Aum, Travis S Tierney
Deep brain stimulation (DBS) has emerged as a revolutionary treatment option for essential tremor (ET), Parkinson's disease (PD), idiopathic dystonia, and severe obsessive-compulsive disorder (OCD). This article reviews the historical foundations of DBS including basal ganglia pathophysiological models, classic principles of electrical stimulation, technical components of the DBS system, treatment risks, and future directions for DBS. Chronic high frequency stimulation induces a number of functional changes from fast physiological to slower metabolic effects and ultimately leads to structural reorganization of the brain, so-called neuroplasticity...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28931260/stereotactic-accuracy-and-surgical-utility-of-the-o-arm-in-deep-brain-stimulation-surgery
#14
Jonathan Dennis Carlson, Kate Elizabeth McLeod, Pamela Sue McLeod, Jamelynn Brooke Mark
BACKGROUND: The stereotactic accuracy of intraoperative imaging is critical to clinical outcome, particularly in "asleep" deep brain stimulation (DBS) surgery that typically forgoes neurophysiological techniques. Different intraoperative imaging modalities and associated accuracies have been reported, including magnetic resonance imaging (MRI), computed tomography (CT), and O-arm. OBJECTIVE: To analyze intraoperative O-arm imaging accuracy and to evaluate the utility of microelectrode mapping...
February 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28941469/ultra-high-field-mri-guided-deep-brain-stimulation
#15
Birte U Forstmann, Bethany R Isaacs, Yasin Temel
Deep brain stimulation (DBS) is a neurosurgical treatment for neurological disorders often planned with 1.5-T or 3-T MRI. The clinical efficacy of DBS can be improved using ultrahigh-field (UHF) MRI for planning by increasing the level of precision required for an individualized approach.
October 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/28951797/earlier-intervention-with-deep-brain-stimulation-for-parkinson-s-disease
#16
REVIEW
Gerson Suarez-Cedeno, Jessika Suescun, Mya C Schiess
Neuromodulation of subcortical areas of the brain as therapy to reduce Parkinsonian motor symptoms was developed in the mid-twentieth century and went through many technical and scientific advances that established specific targets and stimulation parameters. Deep Brain Stimulation (DBS) was approved by the FDA in 2002 as neuromodulation therapy for advanced Parkinson's disease, prompting several randomized controlled trials that confirmed its safety and effectiveness. The implantation of tens of thousands of patients in North America and Europe ignited research into its potential role in early disease stages and the therapeutic benefit of DBS compared to best medical therapy...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28960543/pedunculopontine-nucleus-deep-brain-stimulation-in-parkinson-s-disease-a-clinical-review
#17
REVIEW
Wesley Thevathasan, Bettina Debu, Tipu Aziz, Bastiaan R Bloem, Christian Blahak, Christopher Butson, Virginie Czernecki, Thomas Foltynie, Valerie Fraix, David Grabli, Carole Joint, Andres M Lozano, Michael S Okun, Jill Ostrem, Nicola Pavese, Christoph Schrader, Chun-Hwei Tai, Joachim K Krauss, Elena Moro
Pedunculopontine nucleus region deep brain stimulation (DBS) is a promising but experimental therapy for axial motor deficits in Parkinson's disease (PD), particularly gait freezing and falls. Here, we summarise the clinical application and outcomes reported during the past 10 years. The published dataset is limited, comprising fewer than 100 cases. Furthermore, there is great variability in clinical methodology between and within surgical centers. The most common indication has been severe medication refractory gait freezing (often associated with postural instability)...
September 28, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28961863/systematic-stereotactic-error-reduction-using-a-calibration-technique-in-single-brain-pass-and-multitrack-deep-brain-stimulations
#18
Seong-Cheol Park, Jung Kyo Lee, Seok Min Kim, Eu Jene Choi, Chong Sik Lee
BACKGROUND: A calibration technique that shifts the frame coordinates from the intended coordinates to correct a systematic stereotactic error has been reported for single-brain-pass deep brain stimulation. OBJECTIVE: To analyze the intercenter reproducibility of this method for deep brain stimulation. METHODS: A total of 310 leads from 166 patients undergoing surgery were analyzed, including 220 multitrack (primarily 3-track) subthalamic nucleus leads, 17 single-brain-pass subthalamic nucleus leads, and 73 single-brain-pass globus pallidus interna leads...
August 22, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28961898/a-computerized-microelectrode-recording-to-magnetic-resonance-imaging-mapping-system-for-subthalamic-nucleus-deep-brain-stimulation-surgery
#19
Sunjay S Dodani, Charles W Lu, J Wayne Aldridge, Kelvin L Chou, Parag G Patil
BACKGROUND: Accurate electrode placement is critical to the success of deep brain stimulation (DBS) surgery. Suboptimal targeting may arise from poor initial target localization, frame-based targeting error, or intraoperative brain shift. These uncertainties can make DBS surgery challenging. OBJECTIVE: To develop a computerized system to guide subthalamic nucleus (STN) DBS electrode localization and to estimate the trajectory of intraoperative microelectrode recording (MER) on magnetic resonance (MR) images algorithmically during DBS surgery...
August 5, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28962498/thoracic-surgery-in-patients-with-an-implanted-neurostimulator-device
#20
Kristina Meyring, Adrian Zehnder, Ralph A Schmid, Gregor J Kocher
Movement disorders such as Parkinson's disease are increasingly treated with deep brain stimulators. Being implanted in a subcutaneous pocket in the chest region, thoracic surgical procedures can interfere with such devices, as they are sensible to external electromagnetic forces. Monopolar electrocautery can lead to dysfunction of the device or damage of the brain tissue caused by heat. We report a series of 3 patients with deep brain stimulators who underwent thoracic surgery. By turning off the deep brain stimulators before surgery and avoiding the use of monopolar cautery, electromagnetic interactions were avoided in all patients...
October 1, 2017: Interactive Cardiovascular and Thoracic Surgery
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