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Deep Brain Stimulation literature

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By Andreas Tarnaris Consultant Neurosurgeon
https://www.readbyqxmd.com/read/29920586/determining-the-rotational-orientation-of-directional-deep-brain-stimulation-leads-employing-flat-panel-computed-tomography
#1
Stefan Hunsche, Clemens Neudorfer, Faycal El Majdoub, Mohammad Maarouf, Dieter Sauner
BACKGROUND: Directional deep brain stimulation (DBS) constitutes an emerging technology that allows selective stimulation of target structures via partitioned electrode contacts. In order to effectively perform target-tailored stimulation, knowledge of the rotational orientation of the segmented leads is imperative. OBJECTIVE: To develop a universally applicable and reliable method for determination of lead orientation angles in DBS using flat-panel computed tomography (fpCT)...
June 16, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29880315/subthalamic-deep-brain-stimulation-in-patients-with-primary-dystonia-a-ten-year-follow-up-study
#2
Zhengdao Deng, Yixin Pan, Chencheng Zhang, Jing Zhang, Xian Qiu, Shikun Zhan, Dianyou Li, Bomin Sun
BACKGROUND: Subthalamic deep brain stimulation (STN-DBS) is a promising intervention for primary dystonia; however, evidence regarding its efficacy is lacking. Thus, a long-term follow-up is indispensable. OBJECTIVE: This trial was designed to examine the efficacy and consistency of subthalamic deep brain stimulation in patients with primary dystonia over the long term. METHOD: This was a retrospective study involving 14 patients with primary dystonia who underwent STN-DBS and consented to a follow-up of at least 10 years...
May 31, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29886304/long-term-effect-of-modified-incision-to-prevent-related-complications-in-deep-brain-stimulation
#3
Rongsong Zhou, Wei Liu, Suhua Miao, Yu Ma, Yuqi Zhang
BACKGROUND: Skin complications are a frequent type of complication of deep brain stimulation (DBS) neurosurgical procedure and are always observed in the post-auricular area, scalp area and implantable pulse generator (IPG) pocket. Modifications to the surgical techniques for DBS have been proposed as therapeutic options. To prevent skin complications, we modified the surgical incisions. METHODS: At our center, we first retrospectively analyzed the complications associated with traditional surgical incisions...
June 7, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29886845/opening-the-debate-on-deep-brain-stimulation-for-alzheimer-disease-a-critical-evaluation-of-rationale-shortcomings-and-ethical-justification
#4
Merlin Bittlinger, Sabine Müller
BACKGROUND: Deep brain stimulation (DBS) as investigational intervention for symptomatic relief from Alzheimer disease (AD) has generated big expectations. Our aim is to discuss the ethical justification of this research agenda by examining the underlying research rationale as well as potential methodological pitfalls. The shortcomings we address are of high ethical importance because only scientifically valid research has the potential to be ethical. METHOD: We performed a systematic search on MEDLINE and EMBASE...
June 11, 2018: BMC Medical Ethics
https://www.readbyqxmd.com/read/29890276/both-dbs-and-thalamotomy-in-a-13-year-old-patient-with-primary-dystonia-a-case-report
#5
Hai Lin, Xiao-Dong Cai, Dou-Dou Zhang, Jia-Li Liu, Wei-Ping Li
BACKGROUND: Primary dystonia is a neurological disease with the characteristics of abnormal, involuntary twisting and turning movements, which greatly affects life quality of patients. Treatments for dystonia consist of oral medications, botulinum neurotoxin injections, physical therapy and surgeries. For medication-refractory dystonia, surgeries, especially deep brain stimulation (DBS), are the optimal option. CASE DESCRIPTION: the patient was a 13-year-old boy suffering from extremely severe primary dystonia, with a BFMDRS-M score of 118 and a TWSTRS-S score of 29...
June 8, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29891062/essential-tremor-and-the-cerebellum
#6
Elan D Louis
Essential tremor (ET) is a progressive and highly prevalent neurologic disease. Along with the tremors, mild to moderate gait ataxia and other signs of cerebellar dysfunction may occur (i.e., subtle saccadic eye movement abnormalities and abnormalities of motor timing) as well as cognitive features, some of which may be due to cerebellar dysfunction. Numerous neuroimaging studies indicate the presence of functional, metabolic, and structural abnormalities in the cerebellum of a patient with ET. In tandem with these clinical and imaging studies, which were gathering increasing support for the notion that the cerebellum and/or cerebellar systems seemed to be at the root of ET, a growing postmortem literature is for the first time beginning to identify microscopic abnormalities in the ET brain, most of which are centered on the Purkinje cells and connected neuronal populations, and are likely to be degenerative...
2018: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/29896085/deep-brain-stimulation-a-potential-treatment-for-dementia-in-alzheimer-s-disease-ad-and-parkinson-s-disease-dementia-pdd
#7
REVIEW
Qing Lv, Ailian Du, Wenshi Wei, Yuanyuan Li, Gailing Liu, Xiao Ping Wang
Damage to memory circuits may lead to dementia symptoms in Alzheimer's disease (AD) and Parkinson's disease dementia (PDD). Recently, deep brain stimulation (DBS) has been shown to be a novel means of memory neuromodulation when critical nodes in the memory circuit are targeted, such as the nucleus basalis of Meynert (NBM) and fornix. Potential memory improvements have been observed after DBS in patients with AD and PDD. DBS for the treatment of AD and PDD may be feasible and safe, but it is still preliminary...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29898460/development-of-a-standardized-cranial-phantom-for-training-and-optimization-of-functional-stereotactic-operations
#8
Marie T Krüger, Volker A Coenen, Karl Egger, Mukesch Shah, Peter C Reinacher
BACKGROUND: In recent years, simulations based on phantom models have become increasingly popular in the medical field. In the field of functional and stereotactic neurosurgery, a cranial phantom would be useful to train operative techniques, such as stereo-electroencephalography (SEEG), to establish new methods as well as to develop and modify radiological techniques. In this study, we describe the construction of a cranial phantom and show examples for it in stereotactic and functional neurosurgery and its applicability with different radiological modalities...
June 13, 2018: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/29898975/critical-appraisal-of-the-recent-us-fda-approval-for-earlier-dbs-intervention
#9
REVIEW
Laura Y Cabrera, John Goudreau, Christos Sidiropoulos
In November 2015, Medtronic announced the US Food and Drug Administration (FDA) approval for the use of deep brain stimulation (DBS) therapy in people with Parkinson disease (PD) "of at least 4 years duration and with recent onset motor complications, or motor complications of longer-standing duration that are not adequately controlled with medication." The approval was based on data from the EARLYSTIM clinical trial, a randomized, prospective, multicenter, parallel-group clinical trial in Germany and France involving 251 patients with PD...
June 13, 2018: Neurology
https://www.readbyqxmd.com/read/29900088/improving-the-standard-for-deep-brain-stimulation-therapy-target-structures-and-feedback-signals-for-adaptive-stimulation-current-perspectives-and-future-directions
#10
REVIEW
Franz Hell, Thomas Köglsperger, Jan Mehrkens, Kai Boetzel
Deep brain stimulation (DBS) is an established therapeutic option for the treatment of various neurological disorders and has been used successfully in movement disorders for over 25 years. However, the standard stimulation schemes have not changed substantially. Two major points of interest for the further development of DBS are target-structures and novel adaptive stimulation techniques integrating feedback signals. We describe recent research results on target structures and on neural and behavioural feedback signals for adaptive deep brain stimulation (aDBS), as well as outline future directions...
April 12, 2018: Curēus
https://www.readbyqxmd.com/read/29904585/recent-advances-in-deep-brain-stimulation-in-psychiatric-disorders
#11
REVIEW
Anne-Hélène Clair, William Haynes, Luc Mallet
Deep brain stimulation (DBS) has been offered to patients suffering of severe and resistant neuropsychiatric disorders like Obsessive Compulsive Disorder (OCD), Gilles de la Tourette Syndrome (TS) and Major Depression (MDD). Modulation of several targets within the cortico-striato-thalamo-cortical circuits can lead to a decrease of symptom severity in those patients. This review focuses on the recent clinical outcomes in DBS in psychiatric disorders. Studies on OCD and TS are now focusing on the long-term effects of DBS, with encouraging results regarding not only the decrease of symptoms, but also quality of life...
2018: F1000Research
https://www.readbyqxmd.com/read/29908405/objective-predictors-of-early-tolerance-to-ventral-intermediate-nucleus-of-thalamus-deep-brain-stimulation-in-essential-tremor-patients
#12
Shabbir Hussain Merchant, Sheng-Han Kuo, Yu Qiping, Linda Winfield, Guy McKhann, Sameer Sheth, Seth L Pullman, Blair Ford
OBJECTIVE: To identify pre-operative clinical and computerized spiral analysis characteristics that may help ascertain which patients with Essential Tremor (ET) will exhibit 'early tolerance' to ventral intermediate nucleus of thalamus (Vim) deep brain stimulation (DBS). METHODS: Identification of comparative characteristics of defined cases of 'early tolerance' versus patients with sustained satisfactory response treated with Vim DBS surgery for medically-refractory ET, based on retrospective chart review by a clinician blinded to the findings of computerized spiral analysis...
June 5, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29909184/rates-causes-risk-factors-and-outcomes-of-readmission-following-deep-brain-stimulation-for-movement-disorders-analysis-of-the-u-s-nationwide-readmissions-database
#13
Kavelin Rumalla, Kyle A Smith, Kenneth A Follett, Jules M Nazzaro, Paul M Arnold
OBJECTIVE: Deep brain stimulation (DBS) surgery has proven benefit for several movement disorders and medically-refractory psychiatric conditions and is considered a fairly safe procedure. We sought to determine the national rates, causes, predictors, and outcomes associated with 30-day and 90-day readmission. PATIENTS AND METHODS: The Nationwide Readmissions Database was queried (January-September 2013) using ICD-9-CM codes, identifying patients who underwent DBS for movement disorder (Parkinson's disease [PD], essential tremor [ET], or dystonia)...
June 10, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29909467/subthalamic-deep-brain-stimulation-and-levodopa-in-parkinson-s-disease-a-meta-analysis-of-combined-effects
#14
REVIEW
Joaquin A Vizcarra, Miguel Situ-Kcomt, Carlo Alberto Artusi, Andrew P Duker, Leonardo Lopiano, Michael S Okun, Alberto J Espay, Aristide Merola
INTRODUCTION: While subthalamic nucleus deep brain stimulation (STN-DBS) and levodopa improve motor symptoms in Parkinson disease (PD) to a similar magnitude, their combined effect remains unclear. We sought to evaluate whether STN-DBS and levodopa yield differential effects on motor outcomes, dyskinesia, and activities of daily living (ADL) when combined compared to when administered alone. METHODS: We conducted a meta-analysis of all studies reporting motor, dyskinesia, and ADL outcomes after bilateral STN-DBS in PD with presurgical Unified Parkinson's Disease Rating Scale (UPDRS-III) in Medication-OFF and Medication-ON states and postsurgical assessments in four conditions: Stimulation-ON/Medication-ON, Stimulation-ON/Medication-OFF, Stimulation-OFF/Medication-ON, and Stimulation-OFF/Medication-OFF...
June 16, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29910746/brain-stimulation-in-alzheimer-s-disease
#15
REVIEW
Chun-Hung Chang, Hsien-Yuan Lane, Chieh-Hsin Lin
Brain stimulation techniques can modulate cognitive functions in many neuropsychiatric diseases. Pilot studies have shown promising effects of brain stimulations on Alzheimer's disease (AD). Brain stimulations can be categorized into non-invasive brain stimulation (NIBS) and invasive brain stimulation (IBS). IBS includes deep brain stimulation (DBS), and invasive vagus nerve stimulation (VNS), whereas NIBS includes transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS), transcranial alternating current stimulation (tACS), electroconvulsive treatment (ECT), magnetic seizure therapy (MST), cranial electrostimulation (CES), and non-invasive VNS...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29878147/physiological-mechanisms-of-thalamic-ventral-intermediate-nucleus-stimulation-for-tremor-suppression
#16
Luka Milosevic, Suneil K Kalia, Mojgan Hodaie, Andres M Lozano, Milos R Popovic, William D Hutchison
Ventral intermediate thalamic deep brain stimulation is a standard therapy for the treatment of medically refractory essential tremor and tremor-dominant Parkinson's disease. Despite the therapeutic benefits, the mechanisms of action are varied and complex, and the pathophysiology and genesis of tremor remain unsubstantiated. This intraoperative study investigated the effects of high frequency microstimulation on both neuronal firing and tremor suppression simultaneously. In each of nine essential tremor and two Parkinson's disease patients who underwent stereotactic neurosurgery, two closely spaced (600 µm) microelectrodes were advanced into the ventral intermediate nucleus...
June 5, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29729779/interventional-anesthetic-methods-for-pain-in-hematology-oncology-patients
#17
REVIEW
Holly Careskey, Sanjeet Narang
This article reviews anesthetic interventional approaches to the management of pain in hematology and oncology patients. It includes a discussion of single interventions including peripheral nerve blocks, plexus injections, and sympathetic nerve neurolysis, and continuous infusion therapy through implantable devices, such as intrathecal pumps, epidural port-a-caths, and tunneled catheters. The primary objective is to inform members of hematology and oncology care teams regarding the variety of interventional options for patients with cancer-related pain for whom medical pain management methods have not been effective...
June 2018: Hematology/oncology Clinics of North America
https://www.readbyqxmd.com/read/29729543/craniotomy-for-subdural-hematoma-after-deep-brain-stimulation-surgery-outcomes-and-satisfaction-in-a-case-series-of-two-patients
#18
Gordon Mao, Michael J Gigliotti, Cindy Angle, Donald Whiting, Nestor Tomycz
OBJECTIVE: To determine whether salvage of DBS hardware is beneficial for Parkinson's Disease (PD) patients by looking at follow-up patient's outcomes and satisfaction after their craniotomy operation. PATIENTS AND METHODS: This was a retrospective review of a prospective, single-center deep brain stimulation (DBS) database between 2002-2016 identifying patients with PD who developed subdural hematomas (SDH) due to trauma after their DBS surgery. Of the 636 DBS cases that were performed, 3 PD-DBS patients with significant traumatic SDH managed via craniotomy were identified...
April 27, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29731935/technical-case-report-of-deep-brain-stimulation-is-it-possible-single-electrode-reach-to-both-of-subthalamic-nucleus-and-ventral-intermediate-nucleus-in-one-stage
#19
Hülagu Kaptan, Raif Çakmur
BACKGROUND: The primary target of this operation is Ventral Intermediate Nucleus (VIM); however VIM - Subthalamic Nucleus (STN) were tried to be reached with one electrode, adjusting the angle well, the coronal section; medial of VIM can partially reach the STN. Using the properties of the electrode; we believe we could act on a wide area. METHODS: An analysis was performed on one patient who underwent VIM Deep Brain Stimulation (DBS) in 3 periods (pre - peri - post-operation)...
April 15, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29733955/structural-and-functional-connectivity-of-the-nondecussating-dentato-rubro-thalamic-tract
#20
Kalen J Petersen, Jacqueline A Reid, Srijata Chakravorti, Meher R Juttukonda, Giulia Franco, Paula Trujillo, Adam J Stark, Benoit M Dawant, Manus J Donahue, Daniel O Claassen
The dentato-rubro-thalamic tract (DRTT) regulates motor control, connecting the cerebellum to the thalamus. This tract is modulated by deep-brain stimulation in the surgical treatment of medically refractory tremor, especially in essential tremor, where high-frequency stimulation of the thalamus can improve symptoms. The DRTT is classically described as a decussating pathway, ascending to the contralateral thalamus. However, the existence of a nondecussating (i.e. ipsilateral) DRTT in humans was recently demonstrated, and these tracts are arranged in distinct regions of the superior cerebellar peduncle...
May 4, 2018: NeuroImage
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