Use the collections feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#1
REVIEW
Susan E Williams
Vitamin D supplementation is common in the United States, with about one-fifth of the adult population taking a daily supplement in one form or another. Although the detrimental effects of insufficient sun exposure in childhood was established centuries ago, the beneficial effects of vitamin D sufficiency have only recently been established, given the myriad investigations associating vitamin D deficiency with numerous chronic diseases. But it is far less clear precisely how to replete low 25-hydroxyvitamin D (25[OH]D) levels, how long treatment should be continued, if there are potential hazards in doing so, and how to assess and counsel patients regarding the use of vitamin D...
March 1, 2022: Cleveland Clinic Journal of Medicine
#2
JOURNAL ARTICLE
Micol Romano, Z Serap Arici, David Piskin, Sara Alehashemi, Daniel Aletaha, Karyl S Barron, Susanne Benseler, Roberta Berard, Lori Broderick, Fatma Dedeoglu, Michelle Diebold, Karen L Durrant, Polly Ferguson, Dirk Foell, Jonathan Hausmann, Olcay Y Jones, Daniel L Kastner, Helen J Lachmann, Ronald M Laxer, Dorelia Rivera, Nicolino Ruperto, Anna Simon, Marinka Twilt, Joost Frenkel, Hal Hoffman, Adriana A de Jesus, Jasmin Beate Kuemmerle-Deschner, Seza Ozen, Marco Gattorno, Raphaela Goldbach-Mansky, Erkan Demirkaya
BACKGROUND: The interleukin-1 (IL-1) mediated systemic autoinflammatory diseases, including the cryopyrin-associated periodic syndromes (CAPS), tumour necrosis factor receptor-associated periodic syndrome (TRAPS), mevalonate kinase deficiency (MKD) and deficiency of the IL-1 receptor antagonist (DIRA), belong to a group of rare immunodysregulatory diseases that primarily present in early childhood with variable multiorgan involvement. When untreated, patients with severe clinical phenotypes have a poor prognosis, and diagnosis and management of these patients can be challenging...
July 2022: Annals of the Rheumatic Diseases
#3
REVIEW
Marcia A Friedman, Jeffrey R Curtis, Kevin L Winthrop
Patients with rheumatic diseases are at increased risk of infectious complications; vaccinations are a critical component of their care. Disease-modifying antirheumatic drugs may reduce the immunogenicity of common vaccines. We will review here available data regarding the effect of these medications on influenza, pneumococcal, herpes zoster, SARS-CoV-2, hepatitis B, human papilloma virus and yellow fever vaccines. Rituximab has the most substantial impact on vaccine immunogenicity, which is most profound when vaccinations are given at shorter intervals after rituximab dosing...
October 2021: Annals of the Rheumatic Diseases
#4
JOURNAL ARTICLE
Jeffrey R Curtis, Sindhu R Johnson, Donald D Anthony, Reuben J Arasaratnam, Lindsey R Baden, Anne R Bass, Cassandra Calabrese, Ellen M Gravallese, Rafael Harpaz, Andrew Kroger, Rebecca E Sadun, Amy S Turner, Eleanor Anderson Williams, Ted R Mikuls
OBJECTIVE: To provide guidance to rheumatology providers on the use of coronavirus disease 2019 (COVID-19) vaccines for patients with rheumatic and musculoskeletal diseases (RMDs). METHODS: A task force was assembled that included 9 rheumatologists/immunologists, 2 infectious disease specialists, and 2 public health physicians. After agreeing on scoping questions, an evidence report was created that summarized the published literature and publicly available data regarding COVID-19 vaccine efficacy and safety, as well as literature for other vaccines in RMD patients...
August 2021: Arthritis & Rheumatology
#5
REVIEW
Pascal Sève, Yves Pacheco, François Durupt, Yvan Jamilloux, Mathieu Gerfaud-Valentin, Sylvie Isaac, Loïc Boussel, Alain Calender, Géraldine Androdias, Dominique Valeyre, Thomas El Jammal
Sarcoidosis is a multi-system disease of unknown etiology characterized by the formation of granulomas in various organs. It affects people of all ethnic backgrounds and occurs at any time of life but is more frequent in African Americans and Scandinavians and in adults between 30 and 50 years of age. Sarcoidosis can affect any organ with a frequency varying according to ethnicity, sex and age. Intrathoracic involvement occurs in 90% of patients with symmetrical bilateral hilar adenopathy and/or diffuse lung micronodules, mainly along the lymphatic structures which are the most affected system...
March 31, 2021: Cells
#6
REVIEW
Maria Gloria Mumolo, Francesco Rettura, Sara Melissari, Francesco Costa, Angelo Ricchiuti, Linda Ceccarelli, Nicola de Bortoli, Santino Marchi, Massimo Bellini
The gluten-free diet (GFD) has gained increasing popularity in recent years, supported by marketing campaigns, media messages and social networks. Nevertheless, real knowledge of gluten and GF-related implications for health is still poor among the general population. The GFD has also been suggested for non-celiac gluten/wheat sensitivity (NCG/WS), a clinical entity characterized by intestinal and extraintestinal symptoms induced by gluten ingestion in the absence of celiac disease (CD) or wheat allergy (WA)...
December 10, 2020: Nutrients
#7
JOURNAL ARTICLE
Mar Cabeza-Cabrerizo, Ana Cardoso, Carlos M Minutti, Mariana Pereira da Costa, Caetano Reis e Sousa
Dendritic cells (DCs) possess the ability to integrate information about their environment and communicate it to other leukocytes, shaping adaptive and innate immunity. Over the years, a variety of cell types have been called DCs on the basis of phenotypic and functional attributes. Here, we refocus attention on conventional DCs (cDCs), a discrete cell lineage by ontogenetic and gene expression criteria that best corresponds to the cells originally described in the 1970s. We summarize current knowledge of mouse and human cDC subsets and describe their hematopoietic development and their phenotypic and functional attributes...
April 26, 2021: Annual Review of Immunology
#8
REVIEW
Christine McCusker, Julia Upton, Richard Warrington
Primary immunodeficiency disorder (PID) refers to a large heterogeneous group of disorders that result from defects in immune system development and/or function. PIDs are broadly classified as disorders of adaptive immunity (i.e., T cell, B-cell or combined immunodeficiencies) or of innate immunity (e.g., phagocyte and complement disorders). Although the clinical manifestations of PIDs are highly variable, many disorders involve an increased susceptibility to infection. Early consultation with a clinical immunologist is essential, as timely diagnosis and treatment are imperative for preventing significant disease-associated morbidity...
2018: Allergy, Asthma, and Clinical Immunology
#9
REVIEW
Georges El Hasbani, Mario Viola, Savino Sciascia, Ali T Taher, Imad Uthman
BACKGROUND: The diagnosis of antiphospholipid syndrome (APS) requires the presence of thrombosis and/or recurrent miscarriages along with one or more anti-phospholipid antibodies (aPL). The role of aPL has been largely investigated in systemic lupus erythematosus (SLE) with minimal data on other autoimmune rheumatic diseases. In this review, we aim to assess the prevalence of aPL in patients with inflammatory and autoimmune rheumatic and musculoskeletal diseases (RMDs) other than SLE, and their association with thrombosis...
March 2021: Rheumatology and Therapy
#10
JOURNAL ARTICLE
David B Beck, Marcela A Ferrada, Keith A Sikora, Amanda K Ombrello, Jason C Collins, Wuhong Pei, Nicholas Balanda, Daron L Ross, Daniela Ospina Cardona, Zhijie Wu, Bhavisha Patel, Kalpana Manthiram, Emma M Groarke, Fernanda Gutierrez-Rodrigues, Patrycja Hoffmann, Sofia Rosenzweig, Shuichiro Nakabo, Laura W Dillon, Christopher S Hourigan, Wanxia L Tsai, Sarthak Gupta, Carmelo Carmona-Rivera, Anthony J Asmar, Lisha Xu, Hirotsugu Oda, Wendy Goodspeed, Karyl S Barron, Michele Nehrebecky, Anne Jones, Ryan S Laird, Natalie Deuitch, Dorota Rowczenio, Emily Rominger, Kristina V Wells, Chyi-Chia R Lee, Weixin Wang, Megan Trick, James Mullikin, Gustaf Wigerblad, Stephen Brooks, Stefania Dell'Orso, Zuoming Deng, Jae J Chae, Alina Dulau-Florea, May C V Malicdan, Danica Novacic, Robert A Colbert, Mariana J Kaplan, Massimo Gadina, Sinisa Savic, Helen J Lachmann, Mones Abu-Asab, Benjamin D Solomon, Kyle Retterer, William A Gahl, Shawn M Burgess, Ivona Aksentijevich, Neal S Young, Katherine R Calvo, Achim Werner, Daniel L Kastner, Peter C Grayson
BACKGROUND: Adult-onset inflammatory syndromes often manifest with overlapping clinical features. Variants in ubiquitin-related genes, previously implicated in autoinflammatory disease, may define new disorders. METHODS: We analyzed peripheral-blood exome sequence data independent of clinical phenotype and inheritance pattern to identify deleterious mutations in ubiquitin-related genes. Sanger sequencing, immunoblotting, immunohistochemical testing, flow cytometry, and transcriptome and cytokine profiling were performed...
December 31, 2020: New England Journal of Medicine
#11
REVIEW
Bettina Sehnert, Harald Burkhardt, Stefan Dübel, Reinhard E Voll
Deregulated NF-k activation is not only involved in cancer but also contributes to the pathogenesis of chronic inflammatory diseases like rheumatoid arthritis (RA) and multiple sclerosis (MS). Ideally, therapeutic NF-KappaB inhibition should only take place in those cell types that are involved in disease pathogenesis to maintain physiological cell functions in all other cells. In contrast, unselective NF-kappaB inhibition in all cells results in multiple adverse effects, a major hindrance in drug development...
July 6, 2020: Cells
#12
JOURNAL ARTICLE
António Ferreira, António Oliveira-E-Silva, Paulo Bettencourt
Hydroxychloroquine sulfate (HCQ) is being scrutinized for repositioning in the treatment and prevention of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. This antimalarial drug is also chronically used to treat patients with autoimmune diseases. By analyzing the Portuguese anonymized data on private and public based medical prescriptions we have identified all cases chronically receiving HCQ for the management of diseases, such as systemic lupus erythematosus, rheumatoid arthritis, and other autoimmune diseases...
February 2021: Journal of Medical Virology
#13
REVIEW
Dina Ragab, Haitham Salah Eldin, Mohamed Taeimah, Rasha Khattab, Ramy Salem
COVID-19 is a rapidly spreading global threat that has been declared as a pandemic by the WHO. COVID-19 is transmitted via droplets or direct contact and infects the respiratory tract resulting in pneumonia in most of the cases and acute respiratory distress syndrome (ARDS) in about 15 % of the cases. Mortality in COVID-19 patients has been linked to the presence of the so-called "cytokine storm" induced by the virus. Excessive production of proinflammatory cytokines leads to ARDS aggravation and widespread tissue damage resulting in multi-organ failure and death...
2020: Frontiers in Immunology
#14
JOURNAL ARTICLE
Barbara Schuster, Alexander Zink, Kilian Eyerich
No abstract text is available yet for this article.
November 2020: Allergy
#15
JOURNAL ARTICLE
Marie Kostine, Axel Finckh, Clifton O Bingham, Karen Visser, Jan Leipe, Hendrik Schulze-Koops, Ernest H Choy, Karolina Benesova, Timothy R D J Radstake, Andrew P Cope, Olivier Lambotte, Jacques-Eric Gottenberg, Yves Allenbach, Marianne Visser, Cindy Rusthoven, Lone Thomasen, Shahin Jamal, Aurélien Marabelle, James Larkin, John B A G Haanen, Leonard H Calabrese, Xavier Mariette, Thierry Schaeverbeke
BACKGROUND: Rheumatic and musculoskeletal immune-related adverse events (irAEs) are observed in about 10% of patients with cancer receiving checkpoint inhibitors (CPIs). Given the recent emergence of these events and the lack of guidance for rheumatologists addressing them, a European League Against Rheumatism task force was convened to harmonise expert opinion regarding their identification and management. METHODS: First, the group formulated research questions for a systematic literature review...
January 2021: Annals of the Rheumatic Diseases
#16
REVIEW
Daniel D Bikle
Vitamin D3 is made in the skin from 7-dehydrocholesterol under the influence of UV light. Vitamin D2 (ergocalciferol) is derived from the plant sterol ergosterol. Vitamin D is metabolized first to 25 hydroxyvitamin D (25OHD), then to the hormonal form 1,25-dihydroxyvitamin D (1,25(OH)2D). CYP2R1 is the most important 25-hydroxylase; CYP27B1 is the key 1-hydroxylase. Both 25OHD and 1,25(OH)2D are catabolized by CYP24A1. 1,25(OH)2D is the ligand for the vitamin D receptor (VDR), a transcription factor, binding to sites in the DNA called vitamin D response elements (VDREs)...
March 20, 2014: Chemistry & Biology
#17
JOURNAL ARTICLE
Lauren A Henderson, Scott W Canna, Grant S Schulert, Stefano Volpi, Pui Y Lee, Kate F Kernan, Roberto Caricchio, Shawn Mahmud, Melissa M Hazen, Olha Halyabar, Kacie J Hoyt, Joseph Han, Alexei A Grom, Marco Gattorno, Angelo Ravelli, Fabrizio De Benedetti, Edward M Behrens, Randy Q Cron, Peter A Nigrovic
Poor outcomes in COVID-19 correlate with clinical and laboratory features of cytokine storm syndrome. Broad screening for cytokine storm and early, targeted antiinflammatory therapy may prevent immunopathology and could help conserve limited health care resources. While studies are ongoing, extrapolating from clinical experience in cytokine storm syndromes may benefit the multidisciplinary teams caring for patients with severe COVID-19.
July 2020: Arthritis & Rheumatology
#18
JOURNAL ARTICLE
Lijun Dong, Jun Wu, Kai Chen, Jingwen Xie, Youyi Wang, Dantong Li, Yunzhi Liu, Aiping Yin, Yue Zhao, Yunpeng Han, Jia Zhou, Liyun Zhang, Zhengliang Chen, Daming Zuo
Mannan-binding lectin (MBL) is a vital element in the host innate immune system, which is primarily produced by the liver and secreted into the circulation. Low serum level of MBL is reported to be associated with an increased risk of arthritis. However, the underlying mechanism by which MBL contributes to the pathogenesis of arthritis is poorly understood. In this study, we investigated the precise role of MBL on the course of experimental murine adjuvant-induced arthritis (AIA). MBL-deficient (MBL-/- ) AIA mice showed significantly increased inflammatory responses compared with wild-type C57BL/6 AIA mice, including exacerbated cartilage damage, enhanced histopathological features and high level of tartrate-resistant acid phosphatase (TRAP)-positive cells...
2019: Frontiers in Immunology
#19
REVIEW
Cindy Strehl, Lisa Ehlers, Timo Gaber, Frank Buttgereit
Glucocorticoids regulate fundamental processes of the human body and control cellular functions such as cell metabolism, growth, differentiation, and apoptosis. Moreover, endogenous glucocorticoids link the endocrine and immune system and ensure the correct function of inflammatory events during tissue repair, regeneration, and pathogen elimination via genomic and rapid non-genomic pathways. Due to their strong immunosuppressive, anti-inflammatory and anti-allergic effects on immune cells, tissues and organs, glucocorticoids significantly improve the quality of life of many patients suffering from diseases caused by a dysregulated immune system...
2019: Frontiers in Immunology
#20
REVIEW
Rowan S Hardy, Karim Raza, Mark S Cooper
Therapeutic glucocorticoids have been widely used in rheumatic diseases since they became available over 60 years ago. Despite the advent of more specific biologic therapies, a notable proportion of individuals with chronic rheumatic diseases continue to be treated with these drugs. Glucocorticoids are powerful, broad-spectrum anti-inflammatory agents, but their use is complicated by an equally broad range of adverse effects. The specific cellular mechanisms by which glucocorticoids have their therapeutic action have been difficult to identify, and attempts to develop more selective drugs on the basis of the action of glucocorticoids have proven difficult...
March 2020: Nature Reviews. Rheumatology
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
