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Vasculitis

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15 papers 25 to 100 followers
https://www.readbyqxmd.com/read/27733943/updates-in-anca-associated-vasculitis
#1
Christian Pagnoux
Antineutrophil cytoplasm antibody (ANCA)-associated vasculitides are small-vessel vasculitides that include granulomatosis with polyangiitis (formerly Wegener's granulomatosis), microscopic polyangiitis, and eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome). Renal-limited ANCA-associated vasculitides can be considered the fourth entity. Despite their rarity and still unknown cause(s), research pertaining to ANCA-associated vasculitides has been very active over the past decades. The pathogenic role of antimyeloperoxidase ANCA (MPO-ANCA) has been supported using several animal models, but that of antiproteinase 3 ANCA (PR3-ANCA) has not been as strongly demonstrated...
September 2016: European Journal of Rheumatology
https://www.readbyqxmd.com/read/27347395/recent-advances-in-understanding-and-treating-vasculitis
#2
REVIEW
Matthew J Koster, Kenneth J Warrington
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAVs) are near universally fatal conditions if untreated. Although effective therapeutic options are available for these diseases, treatment regimens are associated with both short- and long-term adverse effects. The recent identification of effective B-cell-targeted therapy with an anti-CD20 monoclonal antibody has transformed the treatment landscape of AAV. Questions, nevertheless, remain regarding the appropriate timing, dose, frequency, duration, and long-term effects of treatment...
2016: F1000Research
https://www.readbyqxmd.com/read/27338776/eular-era-edta-recommendations-for-the-management-of-anca-associated-vasculitis
#3
M Yates, R A Watts, I M Bajema, M C Cid, B Crestani, T Hauser, B Hellmich, J U Holle, M Laudien, M A Little, R A Luqmani, A Mahr, P A Merkel, J Mills, J Mooney, M Segelmark, V Tesar, K Westman, A Vaglio, N Yalçındağ, D R Jayne, C Mukhtyar
In this article, the 2009 European League Against Rheumatism (EULAR) recommendations for the management of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) have been updated. The 2009 recommendations were on the management of primary small and medium vessel vasculitis. The 2015 update has been developed by an international task force representing EULAR, the European Renal Association and the European Vasculitis Society (EUVAS). The recommendations are based upon evidence from systematic literature reviews, as well as expert opinion where appropriate...
September 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/26952547/tocilizumab-for-induction-and-maintenance-of-remission-in-giant-cell-arteritis-a-phase-2-randomised-double-blind-placebo-controlled-trial
#4
RANDOMIZED CONTROLLED TRIAL
Peter M Villiger, Sabine Adler, Stefan Kuchen, Felix Wermelinger, Diana Dan, Veronika Fiege, Lukas Bütikofer, Michael Seitz, Stephan Reichenbach
BACKGROUND: Giant cell arteritis is an immune-mediated disease of medium and large-sized arteries that affects mostly people older than 50 years of age. Treatment with glucocorticoids is the gold-standard and prevents severe vascular complications but is associated with substantial morbidity and mortality. Tocilizumab, a humanised monoclonal antibody against the interleukin-6 receptor, has been associated with rapid induction and maintenance of remission in patients with giant cell arteritis...
May 7, 2016: Lancet
https://www.readbyqxmd.com/read/26798344/behcet-s-disease-is-there-geographical-variation-a-review-far-from-the-silk-road
#5
REVIEW
Nieves Marie Leonardo, Julian McNeil
Behcet's Disease (BD) is a systemic vasculitis characterized by the triad of recurrent mouth and genital ulcers with eye involvement. To date there are no laboratory tests specific for the disease and diagnosis continues to remain on clinical grounds. Multiple criteria have been created as guides for diagnosis; however, given the wide spectrum of organ involvement, some cases remain undiagnosed. The diagnosis of Behcet's Disease may only be made over time as the clinical manifestations emerge sometimes separated by months and even years...
2015: International Journal of Rheumatology
https://www.readbyqxmd.com/read/26557369/canvasc-recommendations-for-the-management-of-antineutrophil-cytoplasm-antibody-anca-associated-vasculitides-executive-summary
#6
REVIEW
Lucy McGeoch, Marinka Twilt, Leilani Famorca, Volodko Bakowsky, Lillian Barra, Susan Benseler, David A Cabral, Simon Carette, Gerald P Cox, Navjot Dhindsa, Christine Dipchand, Aurore Fifi-Mah, Michele Goulet, Nader Khalidi, Majed M Khraishi, Patrick Liang, Nataliya Milman, Christian A Pineau, Heather Reich, Nooshin Samadi, Kam Shojania, Regina Taylor-Gjevre, Tanveer E Towheed, Judith Trudeau, Michael Walsh, Elaine Yacyshyn, Christian Pagnoux
The Canadian Vasculitis research network (CanVasc) is composed of physicians from different medical specialties, including rheumatology and nephrology and researchers with expertise in vasculitis. One of its aims was to develop recommendations for the diagnosis and management of antineutrophil cytoplasm antibody (ANCA)-associated vasculitides in Canada. This executive summary features the 19 recommendations and 17 statements addressing general AAV diagnosis and management, developed by CanVasc group based on a synthesis of existing international guidelines, other published supporting evidence and expert consensus considering the Canadian healthcare context...
2015: Canadian Journal of Kidney Health and Disease
https://www.readbyqxmd.com/read/26523024/canvasc-recommendations-for-the-management-of-antineutrophil-cytoplasm-antibody-associated-vasculitides
#7
REVIEW
Lucy McGeoch, Marinka Twilt, Leilani Famorca, Volodko Bakowsky, Lillian Barra, Susan M Benseler, David A Cabral, Simon Carette, Gerald P Cox, Navjot Dhindsa, Christine S Dipchand, Aurore Fifi-Mah, Michelle Goulet, Nader Khalidi, Majed M Khraishi, Patrick Liang, Nataliya Milman, Christian A Pineau, Heather N Reich, Nooshin Samadi, Kam Shojania, Regina Taylor-Gjevre, Tanveer E Towheed, Judith Trudeau, Michael Walsh, Elaine Yacyshyn, Christian Pagnoux
OBJECTIVE: The Canadian Vasculitis research network (CanVasc) is composed of physicians from different medical specialties and researchers with expertise in vasculitis. One of its aims is to develop recommendations for the diagnosis and management of antineutrophil cytoplasm antibody (ANCA)-associated vasculitides (AAV) in Canada. METHODS: Diagnostic and therapeutic questions were developed based on the results of a national needs assessment survey. A systematic review of existing non-Canadian recommendations and guidelines for the diagnosis and management of AAV and studies of AAV published after the 2009 European League Against Rheumatism/European Vasculitis Society recommendations (publication date: January 2009) until November 2014 was performed in the Medline database, Cochrane library, and main vasculitis conference proceedings...
January 2016: Journal of Rheumatology
https://www.readbyqxmd.com/read/17880578/cutaneous-manifestations-of-wegener-s-granulomatosis-a-clinicopathologic-study-of-17-patients-and-correlation-to-antineutrophil-cytoplasmic-antibody-status
#8
Nneka I Comfere, Nada C Macaron, Lawrence E Gibson
BACKGROUND: Wegener's granulomatosis (WG), a systemic vasculitis, can be associated with cutaneous signs and symptoms before, during or after the diagnosis of systemic disease. METHODS: We reviewed clinical and histologic features of cutaneous lesions from 17 patients with WG. The temporal relationship between development of cutaneous symptoms and onset of systemic disease was determined, and antineutrophil cytoplasmic antibody (ANCA) status of the patients was also established...
October 2007: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/7832276/cutaneous-pathology-in-wegener-s-granulomatosis-a-clinicopathologic-study-of-75-biopsies-in-46-patients
#9
S K Barksdale, C W Hallahan, G S Kerr, A S Fauci, J B Stern, W D Travis
While no cutaneous lesion is specific for Wegener's granulomatosis (WG), several histopathologic entities, including leukocytoclastic vasculitis and necrotizing granulomatous inflammation, are characteristic. This report details the histopathologic features of 75 cutaneous biopsies from 46 patients with WG. Biopsies were subdivided into histologic groups that included leukocytoclastic vasculitis (31%), granulomatous inflammation (GI) (19%), nonspecific ulceration (4%), superficial dermal and epidermal necrosis without inflammation (2...
February 1995: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/26448696/interstitial-lung-disease-with-anca-associated-vasculitis
#10
REVIEW
Yasuhiro Katsumata, Yasushi Kawaguchi, Hisashi Yamanaka
The association between interstitial lung disease (ILD) and anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), particularly microscopic polyangiitis (MPA), has been described in a number of case reports and case series reports in the last 2 decades. In addition, patients with pulmonary fibrosis and ANCA positivity but without other manifestations of systemic vasculitis have also been reported. Pulmonary fibrosis was clinically manifested at the time of diagnosis in the majority of AAV patients that developed this condition...
2015: Clinical Medicine Insights. Circulatory, Respiratory and Pulmonary Medicine
https://www.readbyqxmd.com/read/26377630/omalizumab-in-patients-with-eosinophilic-granulomatosis-with-polyangiitis-a-36-month-follow-up-study
#11
Aikaterini Detoraki, Lorena Di Capua, Gilda Varricchi, Arturo Genovese, Gianni Marone, Giuseppe Spadaro
OBJECTIVE: Eosinophilic granulomatosis with polyangiitis (EGPA) is a systemic vasculitis characterized by asthma and blood eosinophilia, with the lung being the organ most frequently affected. Oral glucocorticoids and/or immunosuppressive drugs are the mainstay therapy of EGPA. Occasional reports suggest that EGPA patients can be treated with omalizumab in addition to conventional therapy to achieve asthma control. To investigate the long-term effects of omalizumab in patients with EGPA and asthma (2 females, 3 males, age 41-64 years), we carried out a 36-month follow-up observational study...
2016: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/25875256/apremilast-for-beh%C3%A3-et-s-syndrome-a-phase-2-placebo-controlled-study
#12
RANDOMIZED CONTROLLED TRIAL
Gulen Hatemi, Melike Melikoglu, Recep Tunc, Cengiz Korkmaz, Banu Turgut Ozturk, Cem Mat, Peter A Merkel, Kenneth T Calamia, Ziqi Liu, Lilia Pineda, Randall M Stevens, Hasan Yazici, Yusuf Yazici
BACKGROUND: Oral ulcers, the hallmark of Behçet's syndrome, can be resistant to conventional treatment; therefore, alternative agents are needed. Apremilast is an oral phosphodiesterase-4 inhibitor that modulates several inflammatory pathways. METHODS: We conducted a phase 2, multicenter, placebo-controlled study in which 111 patients with Behçet's syndrome who had two or more oral ulcers were randomly assigned to receive 30 mg of apremilast twice daily or placebo for 12 weeks...
April 16, 2015: New England Journal of Medicine
https://www.readbyqxmd.com/read/26248811/increased-risk-of-cardiovascular-disease-in-giant-cell-arteritis-a-general-population-based-study
#13
Neda Amiri, Mary De Vera, Hyon K Choi, Eric C Sayre, J Antonio Avina-Zubieta
OBJECTIVE: To determine the risk of newly recorded myocardial infarction (MI) and stroke among incident GCA cases compared with controls from the general population. We also evaluated time trends during follow-up. METHODS: We conducted a matched cohort study (1996-2010) of all patients with incident GCA from the province of British Columbia, Canada. We estimated incidence rates of MI and stroke according to GCA disease duration. We calculated hazard ratios (HRs), adjusting for potential confounders...
January 2016: Rheumatology
https://www.readbyqxmd.com/read/26016768/respiratory-and-otolaryngologic-manifestations-of-giant-cell-arteritis
#14
REVIEW
T F Imran, S Helfgott
OBJECTIVES: The classical presentation of giant cell arteritis (GCA) includes the new onset of headache, scalp tenderness, facial pain or jaw claudication in an older patient. Many patients with GCA have features consistent with the diagnosis of polymyalgia rheumatic (PMR) and nearly all have elevated markers of inflammation such as the erythrocyte sedimentation rate (ESR) or the serum C-reactive protein (CRP). Respiratory and ear-nose-throat (ENT) signs and symptoms such as cough, tongue infarction, trismus, hearing loss and facial swelling are less commonly described, yet they may be the initial presentation of GCA...
March 2015: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/17133251/mechanisms-of-disease-pathogenesis-and-treatment-of-anca-associated-vasculitides
#15
REVIEW
Cees G M Kallenberg, Peter Heeringa, Coen A Stegeman
Wegener's granulomatosis and microscopic polyangiitis are idiopathic systemic vasculitides strongly associated with antineutrophil cytoplasmic autoantibodies (ANCA). In Wegener's granulomatosis, ANCA are mostly directed against proteinase 3 (PR3), whereas in microscopic polyangiitis ANCA are directed against myeloperoxidase; increases in levels of these autoantibodies precede or coincide with clinical relapses in many cases. In vitro, ANCA can further activate primed neutrophils to release reactive oxygen species and lytic enzymes, and, in conjunction with neutrophils, can damage and lyse endothelial cells...
December 2006: Nature Clinical Practice. Rheumatology
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