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Osteoarthritis

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7 papers 0 to 25 followers
https://www.readbyqxmd.com/read/26705327/pulsed-electromagnetic-fields-in-knee-osteoarthritis-a-double-blind-placebo-controlled-randomized-clinical-trial
#1
RANDOMIZED CONTROLLED TRIAL
Gian Luca Bagnato, Giovanni Miceli, Natale Marino, Davide Sciortino, Gian Filippo Bagnato
OBJECTIVES: This trial aimed to test the effectiveness of a wearable pulsed electromagnetic fields (PEMF) device in the management of pain in knee OA patients. METHODS: In this randomized [with equal randomization (1:1)], double-blind, placebo-controlled clinical trial, patients with radiographic evidence of knee OA and persistent pain higher than 40 mm on the visual analog scale (VAS) were recruited. The trial consisted of 12 h daily treatment for 1 month in 60 knee OA patients...
April 2016: Rheumatology
https://www.readbyqxmd.com/read/26921602/new-developments-in-osteoarthritis-and-cartilage-biology
#2
REVIEW
Blandine Poulet, Katherine A Staines
Osteoarthritis (OA) is a degenerative joint disease and the most common form of arthritis. Characterised by articular cartilage loss, subchondral bone thickening and osteophyte formation, the OA joint afflicts much pain and disability. Whilst OA has been associated with many contributing factors, its underpinning molecular mechanisms are, nevertheless, not fully understood. Clinical management of OA is largely palliative and there is an ever growing need for an effective disease modifying treatment. This review discusses some of the recent progress in OA therapies in the different joint tissues affected by OA pathology...
June 2016: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/26543059/painful-knee-but-not-hand-osteoarthritis-is-an-independent-predictor-of-mortality-over-23%C3%A2-years-follow-up-of-a-population-based-cohort-of-middle-aged-women
#3
S Kluzek, M T Sanchez-Santos, K M Leyland, A Judge, T D Spector, D Hart, C Cooper, J Newton, N K Arden
UNLABELLED: To assess whether joint pain or radiographic osteoarthritis (ROA) of the knee and hand is associated with all-cause and disease-specific mortality in middle-aged women. METHODS: Four subgroups from the prospective community-based Chingford Cohort Study were identified based on presence/absence of pain and ROA at baseline: (Pain-/ROA-; Pain+/ROA-; Pain-/ROA+; Pain+/ROA+). Pain was defined as side-specific pain in the preceding month, while side-specific ROA was defined as Kellgren-Lawrence grade ≥2...
October 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/26316704/epidural-injections-with-or-without-steroids-in-managing-chronic-low-back-pain-secondary-to-lumbar-spinal-stenosis-a-meta-analysis-of-13-randomized-controlled-trials
#4
REVIEW
Hai Meng, Qi Fei, Bingqiang Wang, Yong Yang, Dong Li, Jinjun Li, Nan Su
BACKGROUND: Epidural injections of anesthetic with or without steroids are widely used for treating lumbar spinal stenosis, a common cause of chronic low back pain, but there is a lack of rigorous data comparing the effectiveness of epidural injections of anesthetic with and without steroids. This meta-analysis presents a current, comprehensive picture of how epidural injections of anesthetic with steroids compare with those using local anesthetic alone. METHODS: PubMed, Embase, Web of Science, and Cochrane Library databases were searched from their inception through February 5, 2015...
2015: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/26314234/lumbar-intradiskal-platelet-rich-plasma-prp-injections-a-prospective-double-blind-randomized-controlled-study
#5
RANDOMIZED CONTROLLED TRIAL
Yetsa A Tuakli-Wosornu, Alon Terry, Kwadwo Boachie-Adjei, Julian R Harrison, Caitlin K Gribbin, Elizabeth E LaSalle, Joseph T Nguyen, Jennifer L Solomon, Gregory E Lutz
OBJECTIVE: To determine whether single injections of autologous platelet-rich plasma (PRP) into symptomatic degenerative intervertebral disks will improve participant-reported pain and function. DESIGN: Prospective, double-blind, randomized controlled study. SETTING: Outpatient physiatric spine practice. PARTICIPANTS: Adults with chronic (≥6 months), moderate-to-severe lumbar diskogenic pain that was unresponsive to conservative treatment...
January 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/25729331/anti-inflammatory-effects-of-an-injectable-copolymer-of-fatty-acids-ara-3000-beta%C3%A2-in-joint-diseases
#6
Catherine Baugé, Eva Lhuissier, Nicolas Girard, Céline Quesnelle, Gérard Ewert, Karim Boumediene
BACKGROUND: In inflammatory joint disease, such as osteoarthritis or arthritis, there is an increased level of pro-inflammatory cytokines, such as interleukin-1β. These cytokines stimulate the expression and release of matrix metalloproteases (MMP), leading to the degradation of cartilage extracellular matrix and subsequently mobility difficulty and suffering for patients. The aim of this study was to examine the therapeutic potential of a fatty acid copolymer in in vitro and in vivo models of cartilage inflammation...
2015: Journal of Inflammation
https://www.readbyqxmd.com/read/22128078/tumour-necrosis-factor-blockade-for-the-treatment-of-erosive-osteoarthritis-of-the-interphalangeal-finger-joints-a-double-blind-randomised-trial-on-structure-modification
#7
RANDOMIZED CONTROLLED TRIAL
Gust Verbruggen, Ruth Wittoek, Bert Vander Cruyssen, Dirk Elewaut
BACKGROUND: Adalimumab blocks the action of tumor necrosis factor-α and reduces disease progression in rheumatoid arthritis and psoriatic arthritis. The effects of adalimumab in controlling progression of structural damage in erosive hand osteoarthritis (HOA) were assessed. METHODS: Sixty patients with erosive HOA on radiology received 40 mg adalimumab or placebo subcutaneously every two weeks during a 12-month randomized double-blind trial. Response was defined as the reduction in progression of structural damage according to the categorical anatomic phase scoring system...
June 2012: Annals of the Rheumatic Diseases
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