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Genewell panel: ParuchMD

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19 papers 0 to 25 followers Genes related to living well.
By John Paruch Combined training in Internal Medicine-Psychiatry with holistic, evidence-based, preventive approach to implementation and promotion of wellness.
Nicole B Cyrille, Pedro A Villablanca, Harish Ramakrishna
Soluble urokinase plasminogen activation receptor (suPAR) is an emerging new biomarker, which has been shown to not only correlate with traditional biomarkers but also outperform CRP at prognosticating CVD. More clinical trials on suPAR is in the future research agenda.
April 2016: Annals of Cardiac Anaesthesia
Lizhuo Li, Yijun Bao, Songbai He, Gang Wang, Yanlei Guan, Dexuan Ma, Pengfei Wang, Xiaolong Huang, Shanwei Tao, Dewei Zhang, Qiwen Liu, Yunjie Wang, Jingyun Yang
Posttraumatic stress disorder (PTSD) is a complex mental disorder and can severely interfere with the normal life of the affected people. Previous studies have examined the association of PTSD with genetic variants in multiple dopaminergic genes with inconsistent results. To perform a systematic literature search and conduct meta-analysis to examine whether genetic variants in the dopaminergic system is associated with PTSD. Data Sources: PubMed, Cochrane Library, Embase, Google Scholar, and HuGE. Study eligibility criteria and participants: The studies included subjects who had been screened for the presence of PTSD; the studies provided data for genetic variants of genes involved in the dopaminergic system; the outcomes of interest included diagnosis status of PTSD; and the studies were case-control studies...
March 2016: Medicine (Baltimore)
Tetsuro Matsunaga, Ning Gu, Hanae Yamazaki, Mariko Tsuda, Tetsuya Adachi, Koichiro Yasuda, Toshio Moritani, Kinsuke Tsuda, Masahiko Nonaka, Tohru Nishiyama
OBJECTIVES: The mitochondrial uncoupling proteins UCP2 and UCP3 are implicated in energy metabolism and regulation of reactive oxygen species, which are closely involved in autonomic nervous system function. Heart rate variability (HRV) reflects cardiac autonomic regulation and has been used to evaluate dysfunction of the autonomic nervous system in hypertension and cardiovascular diseases. We examined the association between polymorphisms in the UCP2 and UCP3 genes and HRV in healthy young Japanese men...
February 2009: Journal of Hypertension
Barbara Franke, Alejandro Arias Vasquez, Joris A Veltman, Han G Brunner, Mark Rijpkema, Guillén Fernández
BACKGROUND: Genetic variation in CACNA1C has been repeatedly shown to increase risk for psychiatric disorders, with the strongest evidence for involvement in bipolar disorder. To elucidate the mechanisms by which such effects on psychiatric disease are brought about by genetic factors, we investigated the influence of CACNA1C polymorphisms on brain structure. METHODS: In 585 healthy volunteers, for whom magnetic resonance imaging data at 1.5 T (n = 282) or 3 T (n = 304) were available, we tested 193 single nucleotide polymorphisms (SNPs) in or near CACNA1C for association with FSL FIRST-segmented subcortical brain structures and hippocampus as well as SPM5-derived total brain volume and global gray and white matter volume using PLINK...
September 15, 2010: Biological Psychiatry
Benedicte Meyer, Chinh Bkrong Thuy Nguyen, Aurora Moen, Even Fagermoen, Dag Sulheim, Hilde Nilsen, Vegard Bruun Wyller, Johannes Gjerstad
Earlier studies have shown that genetic variability in the SLC6A4 gene encoding the serotonin transporter (5-HTT) may be important for the re-uptake of serotonin (5-HT) in the central nervous system. In the present study we investigated how the 5-HTT genotype i.e. the short (S) versus long (L) 5-HTTLPR allele and the SNP rs25531 A > G affect the physical and psychosocial functioning in patients with chronic fatigue syndrome (CFS). All 120 patients were recruited from The Department of Paediatrics at Oslo University Hospital, Norway, a national referral center for young CFS patients (12-18 years)...
2015: PloS One
O Rivero, M M Selten, S Sich, S Popp, L Bacmeister, E Amendola, M Negwer, D Schubert, F Proft, D Kiser, A G Schmitt, C Gross, S M Kolk, T Strekalova, D van den Hove, T J Resink, N Nadif Kasri, K P Lesch
Cadherin-13 (CDH13), a unique glycosylphosphatidylinositol-anchored member of the cadherin family of cell adhesion molecules, has been identified as a risk gene for attention-deficit/hyperactivity disorder (ADHD) and various comorbid neurodevelopmental and psychiatric conditions, including depression, substance abuse, autism spectrum disorder and violent behavior, while the mechanism whereby CDH13 dysfunction influences pathogenesis of neuropsychiatric disorders remains elusive. Here we explored the potential role of CDH13 in the inhibitory modulation of brain activity by investigating synaptic function of GABAergic interneurons...
2015: Translational Psychiatry
Maria Gabriela Nielsen, Chiara Congiu, Marco Bortolomasi, Cristian Bonvicini, Stefano Bignotti, Maria Abate, Elena Milanesi, Andreas Conca, Nadia Cattane, Elisabetta Tessari, Massimo Gennarelli, Alessandra Minelli
BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) genetic variations have been widely studied in major depressive disorder (MDD) and antidepressants outcome. An interaction with catechol-O-methyltransferase (COMT) has also been proved affecting depression. The aim of this study was to clarify the role of the most commonly studied single nucleotide polymorphisms (SNPs) of MTHFR gene in MDD and in treatment response mechanisms, along with the impact of the interaction with COMT. METHODS: A total of 613 MDD patients, of whom 389 were classified as having treatment resistant depression (TRD), and 463 controls were enrolled...
September 1, 2015: Journal of Affective Disorders
Sereina Bodenmann, Thomas Rusterholz, Roland Dürr, Claudia Stoll, Valérie Bachmann, Eva Geissler, Karin Jaggi-Schwarz, Hans-Peter Landolt
Individual patterns of the electroencephalogram (EEG) in wakefulness and sleep are among the most heritable traits in humans, yet distinct genetic and neurochemical mechanisms underlying EEG phenotypes are largely unknown. A functional polymorphism in the gene encoding catechol-O-methyltransferase (COMT), an enzyme playing an important role in cortical dopamine metabolism, causes a common substitution of methionine (Met) for valine (Val) at codon 158 of COMT protein. Val allele homozygotes exhibit higher COMT activity and lower dopaminergic signaling in prefrontal cortex than Met/Met homozygotes...
September 2, 2009: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Francisco Gomez-Delgado, Juan Francisco Alcala-Diaz, Antonio Garcia-Rios, Javier Delgado-Lista, Ana Ortiz-Morales, Oriol Rangel-Zuñiga, Francisco Jose Tinahones, Lorena Gonzalez-Guardia, Maria M Malagon, Enrique Bellido-Muñoz, Jose M Ordovas, Francisco Perez-Jimenez, Jose Lopez-Miranda, Pablo Perez-Martinez
SCOPE: To examine whether the consumption of a Mediterranean diet (MedDiet), compared with a low-fat diet, interacts with two single nucleotide polymorphisms at the tumor necrosis factor alpha gene (rs1800629, rs1799964) in order to improve triglycerides (TG), glycemic control, and inflammation markers. METHODS AND RESULTS: Genotyping, biochemical measurements, dietary intervention, and oral fat load test meal were determined in 507 metabolic syndrome (MetS) patients selected from all the subjects included in CORDIOPREV clinical trial (n = 1002)...
July 2014: Molecular Nutrition & Food Research
Wen-Hsuan Lan, Albert C Yang, Jen-Ping Hwang, Chen-Jee Hong, Ying-Jay Liou, Heng-Liang Yeh, Mu-En Liu, Shih-Jen Tsai
Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is involved in folate and homocysteine metabolism, and has been associated with geriatric disorders, including dementia and late-life depression. The present work aimed to investigate the effect of MTHFR C677T polymorphism on the presence of depression and loneliness in cognitively normal male subjects. A total of 323 cognitively normal male subjects were included in this study (mean age=80.6; SD=5.3). Depression was assessed by the Geriatric Depression Scale-Short Form (GDS-SF) and loneliness by UCLA loneliness scales...
July 11, 2012: Neuroscience Letters
Odette L J Peerbooms, Jim van Os, Marjan Drukker, Gunter Kenis, Loes Hoogveld, Marc de Hert, Philippe Delespaul, Ruud van Winkel, Bart P F Rutten
Past analyses examining the relationship between genetic variation in the 5, 10-methylenetetrahydrofolate reductase (MTHFR) gene and psychiatric disorders have provided mixed and largely inconclusive findings. MTHFR is involved in the one-carbon metabolic pathway which is essential for DNA biosynthesis and the epigenetic process of DNA methylation. We conducted a meta-analysis of all published case-control studies investigating associations between two common MTHFR single nucleotide polymorphisms (SNPs), MTHFR C677T (sample size 29,502) and A1298C (sample size 7934), and the major psychiatric disorders (i) schizophrenia (SZ), (ii) bipolar disorder (BPD), and (iii) unipolar depressive disorder (UDD)...
November 2011: Brain, Behavior, and Immunity
George I Papakostas, Richard C Shelton, John M Zajecka, Teodoro Bottiglieri, Joshua Roffman, Clair Cassiello, Stephen M Stahl, Maurizio Fava
OBJECTIVE: Specific genetic or biological markers may predict inadequate response to therapy for major depressive disorder (MDD). The objective of the current post hoc analysis was to evaluate the effect of specific biological and genetic markers on the antidepressant efficacy of adjunctive L-methylfolate 15 mg versus placebo from a trial of inadequate responders to selective serotonin reuptake inhibitors (SSRIs). METHOD: The double-blind, randomized, placebo-controlled trial used the sequential parallel comparison design...
August 2014: Journal of Clinical Psychiatry
Kimberly C Paul, Janet S Sinsheimer, Shannon L Rhodes, Myles Cockburn, Jeff Bronstein, Beate Ritz
BACKGROUND: Nitric oxide synthase (NOS) genes are candidates for Parkinson's disease (PD) because NOS enzymes produce nitric oxide (NO), a pro-oxidant that can damage neurons. Widely used organophosphate (OP) pesticides can induce oxidative stress and are reported to increase PD risk. Additionally, two single nucleotide polymorphisms (SNPs) from the PON1 (paraoxonase 1) gene influence the ability to metabolize OPs. OBJECTIVE: Here, we investigated contributions of NOS genes and OP pesticides to PD risk, controlling for PON1 status...
May 2016: Environmental Health Perspectives
(no author information available yet)
Genetic studies have identified a glutamate-ammonia ligase gene (GLUL) polymorphism associated with cardiovascular disease morbidity and mortality among people with type 2 diabetes (T2D). We sought to determine whether GLUL rs10911021 is associated prospectively with adjudicated cardiovascular composite end points among overweight/obese individuals with T2D and whether a lifestyle intervention resulting in weight loss could diminish this association. Look AHEAD is a randomized, controlled trial to determine the effects of intensive lifestyle intervention (ILI), including weight loss and physical activity, relative to diabetes support and education, on cardiovascular outcomes...
January 2016: Diabetes
Adam S Fisch, Laura M Yerges-Armstrong, Joshua D Backman, Hong Wang, Patrick Donnelly, Kathleen A Ryan, Ankita Parihar, Mary A Pavlovich, Braxton D Mitchell, Jeffrey R O'Connell, William Herzog, Christopher R Harman, Jonathan D Wren, Joshua P Lewis
Platelet Endothelial Aggregation Receptor 1 (PEAR1) is a newly identified membrane protein reported to be involved in multiple vascular and thrombotic processes. While most studies to date have focused on the effects of this receptor in platelets, PEAR1 is located in multiple tissues including the endothelium, where it is most highly expressed. Our first objective was to evaluate the role of PEAR1 in endothelial function by examining flow-mediated dilation of the brachial artery in 641 participants from the Heredity and Phenotype Intervention Heart Study...
2015: PloS One
Ya Bin Wei, Lina Martinsson, Jia Jia Liu, Yvonne Forsell, Martin Schalling, Lena Backlund, Catharina Lavebratt
BACKGROUND: Telomeres are protective DNA-protein complexes forming the chromosome ends. TL differs between tissues. Shorter telomere length (TL) in blood leukocytes (LTL) has been associated with major depression, and with previous exposure to childhood adversity. TL studies on non-invasively sampled salivary DNA are less common. Telomerase, with its catalytic subunit hTERT, counteracts telomere shortening. Reduced telomerase activity associates with depression-like behavior in mice. Recently, the minor allele of the hTERT polymorphism rs2736100 was associated with shorter LTL among primarily healthy individuals...
January 1, 2016: Journal of Affective Disorders
Carla C Morais, Maira C Alves, Elaine M Augusto, Dulcinéia S P Abdalla, Maria A Horst, Cristiane Cominetti
AIM: The aim of this study was to investigate possible relationships among the A1298C (rs1801131) and C677T (rs1801133) polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene and levels of homocysteine, vitamins B6, B12, folic acid and lipid profile, including oxidized low-density lipoprotein (ox-LDL), of adolescents at cardiovascular risk. METHODS: We recruited 115 adolescents (10-19 years old), 58.3% (n = 67) female, from a public school in Brazil who underwent anthropometric, biochemical and genetic tests as well as food consumption evaluation...
2015: Journal of Nutrigenetics and Nutrigenomics
Rocio de la Iglesia, Maria L Mansego, Francisco J Sánchez-Muniz, M Angeles Zulet, J Alfredo Martinez
The arylesterase (ARE) activity linked to the paraoxonase-1 (PON1) gene is known to protect lipoproteins from oxidation and provide defense against metabolic syndrome (MetS) and cardiovascular diseases. The epigenetic regulation of enzymatic activities is gaining importance nowadays. This research aimed to assess the potential relationships between the ARE activity with the methylation levels of the PON1 gene transcriptional regulatory region, anthropometrics, biochemical markers and antioxidant dietary components...
2014: EXCLI journal
Kaouthar Abid, Donia Mili, Abderraouf Kenani
Multiple association studies found that the human 9p21.3 chromosome locus is a risk factor for atherosclerosis. The purpose of this study was to investigate the association of the severity and early-onset of coronary artery disease with variant rs1333049 on chromosome 9p21.3 polymorphism and the impact of this variant on cardiovascular risk factors in type 2 diabetic patients. The study population consisted of a control CAD group (101 patients) and 273 consecutive type 2 diabetic patients. Severity and extent of coronary atherosclerosis were scored numerically using the Gensini scoring system...
2015: Disease Markers
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