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ParuchMD

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2 papers 0 to 25 followers John Thomas Paruch, MD - personal collection of scientific articles related to health and wellness
By John Paruch Combined training in Internal Medicine-Psychiatry with holistic, evidence-based, preventive approach to implementation and promotion of wellness.
https://www.readbyqxmd.com/read/20638048/genetic-variation-in-cacna1c-a-gene-associated-with-bipolar-disorder-influences-brainstem-rather-than-gray-matter-volume-in-healthy-individuals
#1
Barbara Franke, Alejandro Arias Vasquez, Joris A Veltman, Han G Brunner, Mark Rijpkema, Guillén Fernández
BACKGROUND: Genetic variation in CACNA1C has been repeatedly shown to increase risk for psychiatric disorders, with the strongest evidence for involvement in bipolar disorder. To elucidate the mechanisms by which such effects on psychiatric disease are brought about by genetic factors, we investigated the influence of CACNA1C polymorphisms on brain structure. METHODS: In 585 healthy volunteers, for whom magnetic resonance imaging data at 1.5 T (n = 282) or 3 T (n = 304) were available, we tested 193 single nucleotide polymorphisms (SNPs) in or near CACNA1C for association with FSL FIRST-segmented subcortical brain structures and hippocampus as well as SPM5-derived total brain volume and global gray and white matter volume using PLINK...
September 15, 2010: Biological Psychiatry
https://www.readbyqxmd.com/read/25198208/a-way-to-reverse-cad
#2
Caldwell B Esselstyn, Gina Gendy, Jonathan Doyle, Mladen Golubic, Michael F Roizen
PURPOSE: Plant-based nutrition achieved coronary artery disease (CAD) arrest and reversal in a small study. However, there was skepticism that this approach could succeed in a larger group of patients. The purpose of our follow-up study was to define the degree of adherence and outcomes of 198 consecutive patient volunteers who received counseling to convert from a usual diet to plant-based nutrition. METHODS: We followed 198 consecutive patients counseled in plant-based nutrition...
July 2014: Journal of Family Practice
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