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Cirugía Oncológica

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12 papers 0 to 25 followers
Matthew M Ladra, Jackie D Szymonifka, Anita Mahajan, Alison M Friedmann, Beow Yong Yeap, Claire P Goebel, Shannon M MacDonald, David R Grosshans, Carlos Rodriguez-Galindo, Karen J Marcus, Nancy J Tarbell, Torunn I Yock
PURPOSE: This prospective phase II study was designed to assess disease control and to describe acute and late adverse effects of treatment with proton radiotherapy in children with rhabdomyosarcoma (RMS). PATIENTS AND METHODS: Fifty-seven patients with localized RMS (age 21 years or younger) or metastatic embryonal RMS (age 2 to 10 years) were enrolled between February 2005 and August 2012. All patients were treated with chemotherapy based on either vincristine, actinomycin, and cyclophosphamide or vincristine, actinomycin, and ifosfamide-based chemotherapy and proton radiation...
November 20, 2014: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Alastair J W Millar, Sharon Cox, Alan Davidson
Wilms tumour is named after Max Wilms. It is an embryonal tumour derived from the metanephros. It is the commonest childhood renal tumour and the third commonest paediatric malignancy. Synchronous bilateral Wilms tumours (BWT) represent 4-7% of all Wilms tumours (WT) and present at a younger age than unilateral Wilms tumours. At least 10% of synchronous BWTs have unfavourable histology, and up to 22% are associated with genitourinary abnormalities, aniridia, WAGR syndrome, Denys-Drash syndrome, hemihypertrophy, or one of the other overgrowth syndromes...
July 2017: Pediatric Surgery International
Douglas S Hawkins, Sheri L Spunt, Stephen X Skapek
In the US, approximately 850-900 children are diagnosed each year with soft tissue sarcomas (STS). Key findings from recent Children's Oncology Group (COG) clinical trials include safe reduction in therapy for low risk rhabdomyosarcoma (RMS), validation of FOXO1 fusion as a prognostic factor, a modest improvement in outcome for high-risk RMS, and a biologically designed non-cytotoxic therapy for pediatric desmoid tumor. Planned Phase 2 trials include targeted agents for VEGF/PDGF, mTOR, and IGF-1R for children with RMS and VEGF for children with non-RMS STS (NRSTS)...
June 2013: Pediatric Blood & Cancer
Hervé J Brisse, M Beth McCarville, Claudio Granata, K Barbara Krug, Sandra L Wootton-Gorges, Kimio Kanegawa, Francesco Giammarile, Matthias Schmidt, Barry L Shulkin, Katherine K Matthay, Valerie J Lewington, Sabine Sarnacki, Barbara Hero, Michio Kaneko, Wendy B London, Andrew D J Pearson, Susan L Cohn, Tom Monclair
Neuroblastoma is an enigmatic disease entity; some tumors disappear spontaneously without any therapy, while others progress with a fatal outcome despite the implementation of maximal modern therapy. However, strong prognostic factors can accurately predict whether children have "good" or "bad" disease at diagnosis, and the clinical stage is currently the most significant and clinically relevant prognostic factor. Therefore, for an individual patient, proper staging is of paramount importance for risk assessment and selection of optimal treatment...
October 2011: Radiology
Brian G A Dalton, Priscilla G Thomas, Nicole E Sharp, Michelle A Manalang, James E Fisher, Christopher R Moir, Shawn D St Peter, Corey W Iqbal
BACKGROUND: Inflammatory myofibroblastic tumor (IMFT) is an uncommon neoplasm in children. METHODS: Retrospective review from 1993 to 2014 of patients ≤18years of age with a histopathologic diagnosis of IMFT treated at two tertiary centers. RESULTS: Thirty-two patients were diagnosed with IMFT. Mean (±SD) age was 9.3±5.7years at diagnosis. Tumor location was variable: abdomen/pelvis (28%), head/neck region (22%), intrathoracic (22%), genitourinary (9%), bowel (6%) liver (6%), and musculoskeletal (6%)...
April 2016: Journal of Pediatric Surgery
Jeffrey S Dome, Norbert Graf, James I Geller, Conrad V Fernandez, Elizabeth A Mullen, Filippo Spreafico, Marry Van den Heuvel-Eibrink, Kathy Pritchard-Jones
Clinical trials in Wilms tumor (WT) have resulted in overall survival rates of greater than 90%. This achievement is especially remarkable because improvements in disease-specific survival have occurred concurrently with a reduction of therapy for large patient subgroups. However, the outcomes for certain patient subgroups, including those with unfavorable histologic and molecular features, bilateral disease, and recurrent disease, remain well below the benchmark survival rate of 90%. Therapy for WT has been advanced in part by an increasingly complex risk-stratification system based on patient age; tumor stage, histology, and volume; response to chemotherapy; and loss of heterozygosity at chromosomes 1p and 16q...
September 20, 2015: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Sajid S Qureshi, Monica Bhagat, Seema Kembhavi, Tushar Vora, Mukta Ramadwar, Girish Chinnaswamy, Maya Prasad, Nehal Khanna, Sidharth Laskar
PURPOSE: Benign liver tumors in children are rare and data regarding the surgical outcomes are deficient. We reviewed our experience in the management of these tumors particularly the extent, safety, and effectiveness of surgical resection. METHODS: Between March 2005 and March 2014, 10/90 liver resections were performed for benign liver tumors. Three other patients received conservative treatment. Demographic characteristics, operative management, morbidity, and mortality were analyzed...
December 2015: Pediatric Surgery International
Omar Nasher, Nigel J Hall, Neil J Sebire, Paolo de Coppi, Agostino Pierro
PURPOSE: Pancreatic tumours in children are exceedingly rare and as a result constitute a diagnostic and therapeutic challenge to paediatric surgeons. We reviewed our experience with these rare entities. METHODS: Retrospective single institution study on all paediatric pancreatic tumours over a period of 38 years (1973-2011) and literature review. We recorded data relating to the clinical features at presentation, diagnostic evaluation, treatment and outcome. RESULTS: Fourteen patients were identified (eight male)...
September 2015: Pediatric Surgery International
Cameron C Trenor, Gulraiz Chaudry
Complex lymphatic anomalies include several diagnoses with overlapping patterns of clinical symptoms, anatomic location, imaging features, hematologic alterations, and complications. Lymphatic malformations likely arise through anomalous embryogenesis of the lymphatic system. Analysis of clinical, imaging, histologic, and hematologic features is often needed to reach a diagnosis. Aspiration of fluid collections can readily define fluid as chylous or not. The presence of chyle indicates dysfunction at the mesenteric or retroperitoneal level or above the cisterna chyli due to reflux...
August 2014: Seminars in Pediatric Surgery
Denise M Adams, Adrienne Hammill
Vascular tumors are rare in children and adults. Classification of these tumors has been difficult, especially in the pediatric population, due to the rarity of these lesions, the unusual morphologic appearance, their diverse clinical behavior, and no independent stratification for pediatric tumors. In 2013, The World Health Organization updated the classification of soft tissue vascular tumors. Pediatric tumors were not independently stratified and the terminology was mostly left unchanged, but the intermediate category of tumors was divided into locally aggressive and rarely metastasizing...
August 2014: Seminars in Pediatric Surgery
Marilyn G Liang, Ilona J Frieden
Infantile hemangiomas (IHs) are the most common benign vascular tumors of infancy. Since they predominantly involute without significant residua, the majority do not require treatment. Indications for intervention include ulceration, prevention of disfigurement, and impairment of function or vital structures. Some IHs have associated structural anomalies. When and which IH to treat requires knowledge of the natural history and clinical findings of increased risk. Congenital hemangiomas (CHs) are fully formed at birth...
August 2014: Seminars in Pediatric Surgery
Daniel J Ledbetter
Although surgical conditions of the thyroid gland are uncommon in children, the increased incidence of thyroid cancer, combined with the fact that children's hospitals are increasingly treating older adolescents, means that it is important that all pediatric surgeons have a knowledge of these conditions. Abnormalities of the thyroid can be associated with abnormalities of thyroid function (hyperthyroidism or hypothyroidism) and/or can be associated with symmetrical or asymmetrical enlargement of the gland.
April 2014: Seminars in Pediatric Surgery
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