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Swine and pain

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Jacob D Brown, Maythem Saeed, Loi Do, Joao Braz, Allan I Basbaum, Michael J Iadarola, David M Wilson, William P Dillon
One approach to analgesia is to block pain at the site of origin or along the peripheral pathway by selectively ablating pain-transmitting neurons or nerve terminals directly. The heat/capsaicin receptor (TRPV1) expressed by nociceptive neurons is a compelling target for selective interventional analgesia because it leaves somatosensory and proprioceptive neurons intact. Resiniferatoxin (RTX), like capsaicin, is a TRPV1 agonist but has greater potency. We combine RTX-mediated inactivation with the precision of computed tomography (CT)-guided delivery to ablate peripheral pain fibers in swine...
September 16, 2015: Science Translational Medicine
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