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Sepsis and lactate

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6 papers 0 to 25 followers
Ata Mahmoodpoor, Kamran Shadvar, Seied Hadi Saghaleini, Evin Koleini, Hadi Hamishehkar, Zohre Ostadi, Nader D Nader
PURPOSE: To predict 28-day mortality with serum lactate and oxygenation profile in sepsis. METHODS: 82 patients were admitted to the ICU with sepsis. Comorbid disease, hemodynamic and oxygenation parameters were recorded. Serum lactate was measured at T0, T6, T12 and T24 hours of admission. Arterial and venous oxygen saturation levels were also measured. Regression and ROC analyses were used to predict death within 28days. RESULTS: Out of 82 patients, 32 died within 28days of ICU admission...
April 2018: Journal of Critical Care
Dennis Djogovic, Shavaun MacDonald, Andrea Wensel, Rob Green, Osama Loubani, Patrick Archambault, Simon Bordeleau, David Messenger, Adam Szulewski, Jon Davidow, Janeva Kircher, Sara Gray, Katherine Smith, James Lee, Jean Marc Benoit, Dan Howes
No abstract text is available yet for this article.
February 2015: CJEM
Roberta Capp, Cheryl Lynn Horton, Sukhjit S Takhar, Adit A Ginde, David A Peak, Richard Zane, Keith A Marill
OBJECTIVES: Approximately one in every four patients who present to the emergency department with sepsis progresses to septic shock within 72 hours of arrival. In this study, we describe key patient characteristics present within 4 hours of emergency department arrival that are associated with developing septic shock between 4 and 48 hours of emergency department arrival. DESIGN AND SETTING: This study was a retrospective chart review study of all patients hospitalized from the emergency department with two or more systemic inflammatory response syndrome criteria present within 4 hours of emergency department arrival from September 2010 to February 2011 at two large academic institutions...
May 2015: Critical Care Medicine
Daniel O Thomas-Rueddel, Bernhard Poidinger, Manfred Weiss, Friedhelm Bach, Karin Dey, Helene Häberle, Udo Kaisers, Hendrik Rüddel, Dirk Schädler, Christian Scheer, Torsten Schreiber, Tobias Schürholz, Philipp Simon, Armin Sommerer, Daniel Schwarzkopf, Andreas Weyland, Gabriele Wöbker, Konrad Reinhart, Frank Bloos
PURPOSE: Current guidelines and most trials do not consider elevated lactate (Lac) serum concentrations when grading sepsis severity. We therefore assessed the association of different types of circulatory dysfunction regarding presence of hyperlactatemia and need for vasopressor support with clinical presentation and outcome of sepsis. METHODS: In a secondary analysis of a prospective observational multicenter cohort study, 988 patients with severe sepsis were investigated regarding vasopressor support, Lac levels, and outcome...
April 2015: Journal of Critical Care
Matthew Dettmer, Christopher V Holthaus, Brian M Fuller
Monitoring in the setting of critical illness must be linked to beneficial therapy to affect clinical outcome. Elevated serum lactate is associated with an increase in mortality in emergency department (ED) patients with severe sepsis and septic shock. The reduction of lactate levels toward normal during acute resuscitation is associated with improved clinical outcomes. The majority of data demonstrating the interventions used to achieve a reduction in lactate levels and the associated clinical outcomes have been obtained during protocolized randomized trials...
January 2015: Shock
Michael A Puskarich, Stephen Trzeciak, Nathan I Shapiro, Andrew B Albers, Alan C Heffner, Jeffrey A Kline, Alan E Jones
BACKGROUND: We sought to compare the association of whole-blood lactate kinetics with survival in patients with septic shock undergoing early quantitative resuscitation. METHODS: This was a preplanned analysis of a multicenter, ED-based, randomized, controlled trial of early sepsis resuscitation. Inclusion criteria were suspected infection, two or more systemic inflammation criteria, either systolic BP< 90 mm Hg after a fluid bolus or lactate level > 4 mM, two serial lactate measurements, and an initial lactate level > 2...
June 2013: Chest
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