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Hidehiro Nakamura, Masafumi Gotoh, Tomonoshin Kanazawa, Keisuke Ohta, Keiichirou Nakamura, Hirokazu Honda, Hiroki Ohzono, Hisao Shimokobe, Yasuhiro Mitsui, Isao Shirachi, Takahiro Okawa, Fujio Higuchi, Masahiro Shirahama, Naoto Shiba, Satoko Matsueda
Corticosteroids (CS) or hyaluronic acid (HA) is used in subacromial injection for the conservative treatment of rotator cuff tears (RCT); this study addresses the question of how CS and HA affect the tendon tissue and fibroblasts in vitro and in rats. Cell proliferation assays were performed in human tendon fibroblasts from RCT. Rats underwent surgery to create RCT, and the surgical sites were injected with CS or HA. The rotator cuff tendons were subjected to biomechanical testing, microscopic and immunohistochemical analysis of proliferating cell nuclear antigen (PCNA), and ultrastructural analysis...
October 2015: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
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