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RCTs in Nephrology

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4 papers 0 to 25 followers
Carmen A Peralta, Leslie A McClure, Rebecca Scherzer, Michelle C Odden, Carole L White, Michael Shlipak, Oscar Benavente, Pablo Pergola
BACKGROUND: The effect of intensive blood pressure (BP) lowering on kidney function among individuals with established cerebrovascular disease and preserved estimated glomerular filtration rate (eGFR) is not established. METHODS AND RESULTS: Among 2610 participants randomized to a lower (<130 mm Hg) versus higher (130-149 mm Hg) systolic BP target with repeated measures of serum creatinine, we evaluated differences by study arm in annualized eGFR decline and rapid decline (eGFR decline >30%) using linear mixed models and logistic regression, respectively...
February 9, 2016: Circulation
Kenneth A Walker, John F Bertram
No abstract text is available yet for this article.
June 2011: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Jessica M Sontrop, Shi-Han Huang, Amit X Garg, Louise Moist, Andrew A House, Kerri Gallo, William F Clark
OBJECTIVES: Increased water intake may have a beneficial effect on the kidney through suppression of plasma vasopressin. We examined the effect of increased water intake on plasma copeptin (a marker of vasopressin) over 6 weeks in patients with chronic kidney disease. DESIGN: Secondary analysis of a randomised controlled parallel-group pilot trial. SETTING: Canada, 2012-2013. PARTICIPANTS: 28 patients with stage 3 chronic kidney disease randomised (2:1) to a hydration (n=17) or control group (n=11)...
November 24, 2015: BMJ Open
Bolesław Rutkowski, Paul Tam, Frank M van der Sande, Andreas Vychytil, Vedat Schwenger, Rainer Himmele, Adelheid Gauly
BACKGROUND: Peritoneal dialysis (PD) solutions with reduced sodium content may have advantages for hypertensive patients; however, they have lower osmolarity and solvent drag, so the achieved Kt/Vurea may be lower. Furthermore, the increased transperitoneal membrane sodium gradient can influence sodium balance with consequences for blood pressure (BP) control. STUDY DESIGN: Prospective, randomized, double-blind clinical trial to prove the noninferiority of total weekly Kt/Vurea with low-sodium versus standard-sodium PD solution, with the lower confidence limit above the clinically accepted difference of -0...
May 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
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