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https://www.readbyqxmd.com/read/26316795/inflammatory-etiopathogenesis-of-systemic-lupus-erythematosus-an-update
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Malgorzata J Podolska, Mona Hc Biermann, Christian Maueröder, Jonas Hahn, Martin Herrmann
The immune system struggles every day between responding to foreign antigens and tolerating self-antigens to delicately maintain tissue homeostasis. If self-tolerance is broken, the development of autoimmunity can be the consequence, as it is in the case of the chronic inflammatory autoimmune disease systemic lupus erythematosus (SLE). SLE is considered to be a multifactorial disease comprising various processes and cell types that act abnormally and in a harmful way. Oxidative stress, infections, or, in general, tissue injury are accompanied by massive cellular demise...
2015: Journal of Inflammation Research
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