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Sepsis Papers

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6 papers 0 to 25 followers
https://www.readbyqxmd.com/read/26386734/triage-sepsis-alert-and-sepsis-protocol-lower-times-to-fluids-and-antibiotics-in-the-ed
#1
Geoffrey E Hayden, Rachel E Tuuri, Rachel Scott, Joseph D Losek, Aaron M Blackshaw, Andrew J Schoenling, Paul J Nietert, Greg A Hall
BACKGROUND: Early identification of sepsis in the emergency department (ED), followed by adequate fluid hydration and appropriate antibiotics, improves patient outcomes. OBJECTIVES: We sought to measure the impact of a sepsis workup and treatment protocol (SWAT) that included an electronic health record (EHR)-based triage sepsis alert, direct communication, mobilization of resources, and standardized order sets. METHODS: We conducted a retrospective, quasiexperimental study of adult ED patients admitted with suspected sepsis, severe sepsis, or septic shock...
January 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27229639/development-and-implementation-of-sepsis-alert-systems
#2
REVIEW
Andrew M Harrison, Ognjen Gajic, Brian W Pickering, Vitaly Herasevich
Development and implementation of sepsis alert systems is challenging, particularly outside the monitored intensive care unit (ICU) setting. Barriers to wider use of sepsis alerts include evolving clinical definitions of sepsis, information overload, and alert fatigue, due to suboptimal alert performance. Outside the ICU, barriers include differences in health care delivery models, charting behaviors, and availability of electronic data. Current evidence does not support routine use of sepsis alert systems in clinical practice...
June 2016: Clinics in Chest Medicine
https://www.readbyqxmd.com/read/26305237/coagulopathy-of-acute-sepsis
#3
REVIEW
Nicola Semeraro, Concetta T Ammollo, Fabrizio Semeraro, Mario Colucci
Coagulopathy is common in acute sepsis and may range from subclinical activation of blood coagulation (hypercoagulability), which may contribute to venous thromboembolism, to acute disseminated intravascular coagulation, characterized by widespread microvascular thrombosis and consumption of platelets and coagulation proteins, eventually causing bleeding. The key event underlying this life-threatening complication is the overwhelming inflammatory host response to the pathogen leading to the overexpression of inflammatory mediators...
September 2015: Seminars in Thrombosis and Hemostasis
https://www.readbyqxmd.com/read/26304288/advances-in-sepsis-research
#4
REVIEW
Peter Bentzer, James A Russell, Keith R Walley
Recent research has identified promising targets for therapeutic interventions aimed at modulating the inflammatory response in sepsis. Herein, the authors describe mechanisms involved in the clearance of pathogen toxin from the circulation and potential interventions aimed at enhancing clearance mechanisms. The authors also describe advances in the understanding of the innate immune response as potential therapeutic targets. Finally, novel potential treatment strategies aimed at decreasing vascular leak are discussed...
September 2015: Clinics in Chest Medicine
https://www.readbyqxmd.com/read/26291900/targeted-fluid-minimization-following-initial-resuscitation-in-septic-shock-a-pilot-study
#5
RANDOMIZED CONTROLLED TRIAL
Catherine Chen, Marin H Kollef
BACKGROUND: IV fluid represents a basic therapeutic intervention for septic shock. Unfortunately, the optimal administration of IV fluid to maximize patient outcomes and prevent complications is largely unknown. METHODS: Patients with septic shock admitted to the medical ICUs of Barnes-Jewish Hospital (January to December 2014) requiring vasoactive agents for at least 12 h following initial fluid resuscitation were randomized to usual care or to targeted fluid minimization (TFM) guided by daily assessments of fluid responsiveness...
December 2015: Chest
https://www.readbyqxmd.com/read/26316210/early-goal-directed-resuscitation-of-patients-with-septic-shock-current-evidence-and-future-directions
#6
REVIEW
Ravi G Gupta, Sarah M Hartigan, Markos G Kashiouris, Curtis N Sessler, Gonzalo M L Bearman
Severe sepsis and septic shock are among the leading causes of mortality in the intensive care unit. Over a decade ago, early goal-directed therapy (EGDT) emerged as a novel approach for reducing sepsis mortality and was incorporated into guidelines published by the international Surviving Sepsis Campaign. In addition to requiring early detection of sepsis and prompt initiation of antibiotics, the EGDT protocol requires invasive patient monitoring to guide resuscitation with intravenous fluids, vasopressors, red cell transfusions, and inotropes...
August 28, 2015: Critical Care: the Official Journal of the Critical Care Forum
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