Read by QxMD icon Read

Journal club

shared collection
20 papers 0 to 25 followers
Landon E Stigall, David G Brodland, John A Zitelli
BACKGROUND: Evaluation of the entire surgical margin results in high rates of complete excision, low local recurrence rates, and maximal tissue conservation. Although well recognized for melanoma of the head and neck, few studies have focused exclusively on the trunk and proximal extremities. OBJECTIVE: We sought to evaluate the efficacy of Mohs micrographic surgery for melanoma in situ (MIS) of the trunk and proximal extremities, and determine adequate excision margins for MIS when total margin evaluation is not used...
November 2016: Journal of the American Academy of Dermatology
Marie-Charlotte Brüggen, Wolfgang Bauer, Bärbel Reininger, Eduard Clim, Catalin Captarencu, Georg E Steiner, Patrick M Brunner, Barbara Meier, Lars E French, Georg Stingl
Although innate lymphoid cells (ILCs) have recently been identified also in skin, their role in this organ remains poorly understood. In this study, we aimed at developing a technique to assess ILCs in situ and to determine their topographical distribution in human skin. We collected lesional skin biopsies from atopic dermatitis (AD) and psoriasis (Pso) patients (both n=13) and normal human skin (NHS) from healthy controls. After establishing immunofluorescence ILC in situ stainings, we developed an analysis approach (gating combined with manual validation) to reliably identify ILCs...
July 22, 2016: Journal of Investigative Dermatology
Yaxiong Deng, Christopher Chang, Qianjin Lu
Psoriasis is a chronic inflammatory autoimmune disease characterized by an excessively aberrant hyperproliferation of keratinocytes. The pathogenesis of psoriasis is complex and the exact mechanism remains elusive. However, psoriasis is thought to result from a combination of genetic, epigenetic, and environmental influences. Recent studies have identified that epigenetic factors including dysregulated DNA methylation levels, abnormal histone modification and microRNAs expressions are involved in the development of psoriasis...
June 2016: Clinical Reviews in Allergy & Immunology
P Staubach, T Zuberbier, C Vestergaard, F Siebenhaar, E Toubi, G Sussman
This supplement reports proceedings of the second international Global Urticaria Forum, which was held in Berlin, Germany in November 2015. Despite the clear international guideline, there remain a number of controversies and challenges in the management of patients with chronic urticaria (CU). As a result of major advancements in urticaria over the past 4 years, the current EAACI/GA(2) LEN/EDF/WAO urticaria guideline treatment algorithm requires updating. Case studies from patients with chronic spontaneous urticaria (CSU) [also called chronic idiopathic urticaria (CIU)], chronic inducible urticaria (CIndU) or diseases and syndromes related to CU are useful in describing and exploring challenges in disease management...
July 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
Maja A Hofmann, Felix Kiecker, Torsten Zuberbier
PURPOSE OF REVIEW: Allergic skin diseases include atopic dermatitis/eczema, contact dermatitis, and drug hypersensitivity. Allergic skin diseases have a high prevalence. Atopic dermatitis is one of the most common inflammatory skin diseases and similar for allergic rhinitis and allergic asthma. Over a long period, allergic diseases have been regarded as immunoglobulin E-mediated T-helper-2 (Th2)-driven. But new cytokines and T cells have been discovered within the last years. In this systematic review, the focus is laid on interleukin-17 (IL-17) and the interleukin-20 (IL-20) family which appear to be fine-tuning the Th2-driven answer...
October 2016: Current Opinion in Allergy and Clinical Immunology
A Katharina Simon, Georg A Hollander, Andrew McMichael
This article reviews the development of the immune response through neonatal, infant and adult life, including pregnancy, ending with the decline in old age. A picture emerges of a child born with an immature, innate and adaptive immune system, which matures and acquires memory as he or she grows. It then goes into decline in old age. These changes are considered alongside the risks of different types of infection, autoimmune disease and malignancy.
December 22, 2015: Proceedings. Biological Sciences
Anthony S Fauci, David M Morens
The explosive pandemic of Zika virus infection occurring throughout South America, Central America, and the Caribbean (see map) and potentially threatening the United States is the most recent of four unexpected arrivals of important arthropod-borne viral diseases in the Western Hemisphere over the..
February 18, 2016: New England Journal of Medicine
Peter Doherty
No abstract text is available yet for this article.
February 2016: Nature Reviews. Immunology
K Jade Kindley, Jeremy D Jackson, William Taylor Sisson, Robert Brodell
No abstract text is available yet for this article.
July 2015: International Journal of Health Sciences
Eoin R Storan, Marian T McEvoy, David A Wetter, Rokea A el-Azhary, Alina G Bridges, Michael J Camilleri, Mark D P Davis
BACKGROUND: Intensive treatment options are lacking for patients with severe skin disease recalcitrant to outpatient therapy. The availability of inpatient dermatology care has almost disappeared in many parts of the United States. One possible solution for this is a day treatment center for patients with severe dermatologic disease recalcitrant to outpatient therapy. METHODS: Descriptive study based on retrospective medical record review of all patients attending the day hospital for treatment in 2010...
2015: International Journal of Dermatology
Elizabeth A Grice
The past two decades have been marked by a surge in research to understand the microbial communities that live in association with the human body, in part stimulated by affordable, high-throughput DNA sequencing technology. In the context of the skin, this Perspective focuses on the current state of genomic- and metagenomic-based host-microbe research and future challenges and opportunities to move the field forward. These include elucidating nonbacterial components of the skin microbiome (i.e., viruses); systematic studies to address common perturbations to the skin microbiome (e...
October 2015: Genome Research
Parul Ganju, Sunil Nagpal, M H Mohammed, P Nishal Kumar, Rajesh Pandey, Vivek T Natarajan, Sharmila S Mande, Rajesh S Gokhale
Healthy human skin harbours a diverse array of microbes that comprise the skin microbiome. Commensal bacteria constitute an important component of resident microbiome and are intricately linked to skin health. Recent studies describe an association between altered skin microbial community and epidemiology of diseases, like psoriasis, atopic dermatitis etc. In this study, we compare the differences in bacterial community of lesional and non-lesional skin of vitiligo subjects. Our study reveals dysbiosis in the diversity of microbial community structure in lesional skin of vitiligo subjects...
2016: Scientific Reports
Amit Garg, Katie Biello, Joyce W Hoot, Shalini B Reddy, Lindsay Wilson, Paul George, Leslie Robinson-Bostom, Leah Belazarian, Erik Domingues, Jennifer Powers, Reza Jacob, Michael Powers, Justin Besen, Alan C Geller
BACKGROUND: Assessing medical students on core skills related to melanoma detection is challenging in the absence of a well-developed instrument. OBJECTIVE: We sought to develop an objective structured clinical examination for the detection and evaluation of melanoma among medical students. METHODS: This was a prospective cohort analysis of student and objective rater agreement on performance of clinical skills and assessment of differences in performance across 3 schools...
December 2015: Journal of the American Academy of Dermatology
Maulina Sharma, Cathy Bennett, Ben Carter, Stuart N Cohen
BACKGROUND: Chronic spontaneous urticaria is characterized by recurrent itchy wheals. First-line management is with H1-antihistamines. OBJECTIVE: We sought to conduct a Cochrane Review of H1-antihistamines in the treatment of chronic spontaneous urticaria. METHODS: A systematic search of major databases for randomized controlled trials was conducted. RESULTS: We included 73 studies with 9759 participants; 34 studies provided outcome data for 23 comparisons...
October 2015: Journal of the American Academy of Dermatology
Tarig Elraiyah, Michael R Gionfriddo, Victor M Montori, Mohammad Hassan Murad
No abstract text is available yet for this article.
December 1, 2015: Annals of Internal Medicine
Claire E Powers, Diana B McShane, Peter H Gilligan, Craig N Burkhart, Dean S Morrell
Atopic dermatitis is a chronic inflammatory skin condition with drastic impacts on pediatric health. The pathogenesis of this common disease is not well understood, and the complex role of the skin microbiome in the pathogenesis and progression of atopic dermatitis is being elucidated. Skin commensal organisms promote normal immune system functions and prevent the colonization of pathogens. Alterations in the skin microbiome may lead to increased Staphylococcus aureus colonization and atopic dermatitis progression...
December 2015: Journal of Dermatology
Michael R Williams, Richard L Gallo
Atopic dermatitis (AD) is a common skin disease that affects a large proportion of the population worldwide. The incidence of AD has increased over the last several decades along with AD's burden on the physical and psychological health of the patient and family. However, current advances in understanding the mechanisms behind the pathophysiology of AD are leading to a hopeful outlook for the future. Staphylococcus aureus (S. aureus) colonization on AD skin has been directly correlated to disease severity but the functions of other members of the skin bacterial community may be equally important...
November 2015: Current Allergy and Asthma Reports
Vivian Y Shi, Michael Leo, Lauren Hassoun, Dev S Chahal, Howard I Maibach, Raja K Sivamani
Skin is an important interface between the host and its environment. Inflammatory dermatoses often have disrupted skin barrier function, rendering patients more susceptible to allergenic triggers leading to an exaggerated immune response. The skin surface lipid film, an important component of the skin barrier, comprises a mixture of keratinocyte and sebaceous gland-derived lipids. Recent evidence demonstrated that defective keratinocyte lipid synthesis predisposes for the development of atopic dermatitis. However, the important role of sebaceous gland-derived lipids in skin inflammatory diseases may be underrecognized...
November 2015: Journal of the American Academy of Dermatology
Yu Zhang, Helen C Su, Michael J Lenardo
No abstract text is available yet for this article.
October 2015: Nature Immunology
Stephan Weidinger, Natalija Novak
Atopic dermatitis (also known as atopic eczema) is a chronic inflammatory skin disease that is characterised by intense itching and recurrent eczematous lesions. Although it most often starts in infancy and affects two of ten children, it is also highly prevalent in adults. It is the leading non-fatal health burden attributable to skin diseases, inflicts a substantial psychosocial burden on patients and their relatives, and increases the risk of food allergy, asthma, allergic rhinitis, other immune-mediated inflammatory diseases, and mental health disorders...
March 12, 2016: Lancet
2015-09-22 05:58:39
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"