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Neuropsychology

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453 papers 100 to 500 followers
https://www.readbyqxmd.com/read/28486641/current-clinical-brain-tumor-imaging
#1
Javier E Villanueva-Meyer, Marc C Mabray, Soonmee Cha
Neuroimaging plays an ever evolving role in the diagnosis, treatment planning, and post-therapy assessment of brain tumors. This review provides an overview of current magnetic resonance imaging (MRI) methods routinely employed in the care of the brain tumor patient. Specifically, we focus on advanced techniques including diffusion, perfusion, spectroscopy, tractography, and functional MRI as they pertain to noninvasive characterization of brain tumors and pretreatment evaluation. The utility of both structural and physiological MRI in the post-therapeutic brain evaluation is also reviewed with special attention to the challenges presented by pseudoprogression and pseudoresponse...
May 9, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28547588/neurocognition-in-individuals-with-incidentally-identified-meningioma
#2
Alissa M Butts, Stephen Weigand, Paul D Brown, Ronald C Petersen, Clifford R Jack, Mary M Machulda, Jane H Cerhan
Meningiomas are primary intracranial tumors that are often asymptomatic. To our knowledge, no study has attempted to describe neurocognitive function in patients with incidentally-discovered meningioma. We utilized the Mayo Clinic Study of Aging (MCSA), which is a population-based sample of Olmsted County, Minnesota residents that includes neuropsychological testing and brain MRI approximately every 15 months. Using a text search of radiologists' notes of 2402 MCSA individuals (mean age 77 years, scanned between 2004 and 2014) we identified 48 eligible subjects (2%) who had at least one meningioma...
May 25, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28492341/implications-of-neurovascular-uncoupling-in-functional-magnetic-resonance-imaging-fmri-of-brain-tumors
#3
Rebecca W Pak, Darian H Hadjiabadi, Janaka Senarathna, Shruti Agarwal, Nitish V Thakor, Jay J Pillai, Arvind P Pathak
Functional magnetic resonance imaging (fMRI) serves as a critical tool for presurgical mapping of eloquent cortex and changes in neurological function in patients diagnosed with brain tumors. However, the blood-oxygen-level-dependent (BOLD) contrast mechanism underlying fMRI assumes that neurovascular coupling remains intact during brain tumor progression, and that measured changes in cerebral blood flow (CBF) are correlated with neuronal function. Recent preclinical and clinical studies have demonstrated that even low-grade brain tumors can exhibit neurovascular uncoupling (NVU), which can confound interpretation of fMRI data...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28616382/improving-language-mapping-in-clinical-fmri-through-assessment-of-grammar
#4
Monika Połczyńska, Kevin Japardi, Susan Curtiss, Teena Moody, Christopher Benjamin, Andrew Cho, Celia Vigil, Taylor Kuhn, Michael Jones, Susan Bookheimer
INTRODUCTION: Brain surgery in the language dominant hemisphere remains challenging due to unintended post-surgical language deficits, despite using pre-surgical functional magnetic resonance (fMRI) and intraoperative cortical stimulation. Moreover, patients are often recommended not to undergo surgery if the accompanying risk to language appears to be too high. While standard fMRI language mapping protocols may have relatively good predictive value at the group level, they remain sub-optimal on an individual level...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28583454/functional-connectivity-in-the-fronto-parietal-network-an-indicator-of-pre-operative-cognitive-function-and-cognitive-outcome-following-surgery-in-patients-with-glioma
#5
Stefan Lang, Ismael Gaxiola-Valdez, Michael Opoku-Darko, Lisa A Partlo, Bradley G Goodyear, John J P Kelly, Paolo Federico
BACKGROUND: Patients with diffuse glioma are known to have impaired cognitive functions pre-operatively. However, the mechanism of these cognitive deficits remains unclear. Resting state functional connectivity in the fronto-parietal network (FPN) is associated with cognitive performance in healthy subjects. For this reason, it was hypothesized that functional connectivity of the FPN would be related to cognitive functioning in patients with glioma. To assess this relationship, pre-operative cognitive status was correlated to patient specific connectivity within the FPN...
June 2, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28501875/five-year-neuropsychological-outcome-after-stereotactic-radiofrequency-amygdalohippocampectomy-for-mesial-temporal-lobe-epilepsy-longitudinal-study
#6
Lenka Krámská, Zdeněk Vojtěch, Jiří Lukavský, Michaela Stará, Hana Malíková
PURPOSE: To assess the neuropsychological performance recoded over a period of 5 years after stereotactic radiofrequency amygdalohippocampectomy (SAHE) in the treatment of mesial temporal lobe epilepsy. MATERIAL AND METHODS: Thirty patients (mean age 38 years, 14 females/16 males) were included in this study. Twenty-one patients were treated on the left side, 9 on the right. Patients underwent neuropsychological evaluation by the Wechsler Adult Intelligence Scale-Revised and the Wechsler Memory Scale-Revised preoperatively and 5 years after SAHE...
May 13, 2017: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/28582572/surgical-treatment-of-mesiotemporal-lobe-epilepsy-which-approach-is-favorable
#7
Barbara Schmeiser, Kathrin Wagner, Andreas Schulze-Bonhage, Irina Mader, Anne-Sophie Wendling, Bernhard Jochen Steinhoff, Marco Prinz, Christian Scheiwe, Astrid Weyerbrock, Josef Zentner
BACKGROUND: Mesiotemporal lobe epilepsy is one of the most frequent causes for pharmacoresistant epilepsy. Different surgical approaches to the mesiotemporal area are used. OBJECTIVE: To analyze epileptological and neuropsychological results as well as complications of different surgical strategies. METHODS: This retrospective study is based on a consecutive series of 458 patients all harboring pharmacoresistant mesiotemporal lobe epilepsy...
June 2, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28595352/neuropsychology-outcomes-following-trephine-epilepsy-surgery-the-inferior-temporal-gyrus-approach-for-amygdalohippocampectomy-in-medically-refractory-mesial-temporal-lobe-epilepsy
#8
Mike R Schoenberg, William E Clifton, Ryan W Sever, Fernando L Vale
BACKGROUND: Surgery is indicated in cases of mesial temporal lobe epilepsy(MTLE) that are refractory to medical management. The inferior temporal gyrus (ITG) approach provides access to the mesial temporal lobe (MTL) structures with minimal tissue disruption. Reported neuropsychology outcomes following this approach are limited. OBJECTIVE: To report neuropsychological outcomes using an ITG approach to amygdalohippocampectomy (AH) in patients with medically refractory MTLE based on a prospective design...
June 8, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28474122/survey-on-current-cognitive-practices-within-the-european-low-grade-glioma-network-towards-a-european-assessment-protocol
#9
Adrià Rofes, Emmanuel Mandonnet, John Godden, Marie Hélène Baron, Henry Colle, Amelie Darlix, Vânia de Aguiar, Hugues Duffau, Guillaume Herbet, Martin Klein, Vincent Lubrano, Juan Martino, Ryan Mathew, Gabriele Miceli, Sylvie Moritz-Gasser, Johan Pallud, Costanza Papagno, Fabien Rech, Erik Robert, Geert-Jan Rutten, Thomas Santarius, Djaina Satoer, Joanna Sierpowska, Anja Smits, Miran Skrap, Giannantonio Spena, Evy Visch, Elke De Witte, Maria Zetterling, Michel Wager
BACKGROUND: The European Low-Grade Glioma network indicated a need to better understand common practices regarding the managing of diffuse low-grade gliomas. This area has experienced great advances in recent years. METHOD: A general survey on the managing of diffuse low-grade gliomas was answered by 21 centres in 11 European countries. Here we focused on specific questions regarding perioperative and intraoperative cognitive assessments. RESULTS: More centres referred to the same speech and language therapist and/or neuropsychologist across all assessments; a core of assessment tools was routinely used across centres; fluency tasks were commonly used in the perioperative stages, and object naming during surgery; tasks that tapped on attention, executive functions, visuospatial awareness, calculation and emotions were sparsely administered; preoperative assessments were performed 1 month or 1 week before surgery; timing for postoperative assessments varied; finally, more centres recommended early rehabilitation, whenever needed...
July 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28544168/presurgical-language-fmri-mapping-of-six-critical-regions
#10
Christopher F Benjamin, Patricia D Walshaw, Kayleigh Hale, William D Gaillard, Leslie C Baxter, Madison M Berl, Monika Polczynska, Stephanie Noble, Rafeed Alkawadri, Lawrence J Hirsch, R Todd Constable, Susan Y Bookheimer
Language mapping is a key goal in neurosurgical planning. fMRI mapping typically proceeds with a focus on Broca's and Wernicke's areas, although multiple other language-critical areas are now well-known. We evaluated whether clinicians could use a novel approach, including clinician-driven individualized thresholding, to reliably identify six language regions, including Broca's Area, Wernicke's Area (inferior, superior), Exner's Area, Supplementary Speech Area, Angular Gyrus, and Basal Temporal Language Area...
May 23, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28453603/the-effect-of-insomnia-on-neuropsychological-functioning-in-patients-with-comorbid-symptoms-of-pain-fatigue-and-mood-disorders
#11
Julie Aasvik, Tore C Stiles, Astrid Woodhouse, Petter Borchgrevink, Nils Inge Landrø
Objectives: To examine if elevated symptoms of insomnia affects neuropsychological functioning in patients with concurrent symptoms of pain, fatigue, and mood disorders. Methods and results: A total of seventy-six subjects participated in this (cross-sectional) study. Based on the cut-off score guidelines from The Insomnia Severity Index subjects were assigned to either a clinical insomnia group (N = 35) or a comparison group (N = 41). Factors such as age, general cognitive functioning, and symptoms of pain, fatigue, depression, and anxiety did not differ between the groups...
April 27, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28444123/a-comparison-of-four-computerized-neurocognitive-assessment-tools%C3%A2-to-a-traditional-neuropsychological-test-battery-in-service-members-with-and-without-mild-traumatic-brain-injury
#12
Wesley R Cole, Jacques P Arrieux, Brian J Ivins, Karen A Schwab, Felicia M Qashu
Objective: Computerized neurocognitive assessment tools (NCATS) are often used as a screening tool to identify cognitive deficits after mild traumatic brain injury (mTBI). However, differing methodology across studies renders it difficult to identify a consensus regarding the validity of NCATs. Thus, studies where multiple NCATs are administered in the same sample using the same methodology are warranted. Method: We investigated the validity of four NCATs: the ANAM4, CNS-VS, CogState, and ImPACT...
April 24, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28427934/cognitive-subtypes-of-probable-alzheimer-s-disease-robustly-identified-in%C3%A2-four-cohorts
#13
Nienke M E Scheltens, Betty M Tijms, Teddy Koene, Frederik Barkhof, Charlotte E Teunissen, Steffen Wolfsgruber, Michael Wagner, Johannes Kornhuber, Oliver Peters, Brendan I Cohn-Sheehy, Gil D Rabinovici, Bruce L Miller, Joel H Kramer, Philip Scheltens, Wiesje M van der Flier
INTRODUCTION: Patients with Alzheimer's disease (AD) show heterogeneity in profile of cognitive impairment. We aimed to identify cognitive subtypes in four large AD cohorts using a data-driven clustering approach. METHODS: We included probable AD dementia patients from the Amsterdam Dementia Cohort (n = 496), Alzheimer's Disease Neuroimaging Initiative (n = 376), German Dementia Competence Network (n = 521), and University of California, San Francisco (n = 589)...
April 17, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28427970/structured-evaluation-of-glioma-patients-by-an-occupational-therapist-is-our-clinical-examination-enough
#14
Christian Franz Freyschlag, Johannes Kerschbaumer, Daniel Pinggera, Gabriele Bacher, Claudius Thomé
BACKGROUND: Preservation of neurological function is mandatory when offering a surgical intervention to patients with low-grade gliomas (LGG), given that the goal of any treatment is the patient's return to their normal everyday life. OBJECTIVE: To determine whether a structured evaluation by an occupational therapist can reveal deficits that might be overseen in routine clinical examination of patients with a surgically treated LGG. METHODS: 20 patients with radiographically suspected LGG have been examined in a standardized fashion at three stages: pre-, postoperatively and three months thereafter...
April 17, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28432987/multimodal-imaging-of-language-reorganization-in-patients-with-left-temporal-lobe-epilepsy
#15
Yu-Hsuan A Chang, Nobuko Kemmotsu, Kelly M Leyden, N Erkut Kucukboyaci, Vicente J Iragui, Evelyn S Tecoma, Leena Kansal, Marc A Norman, Rachelle Compton, Tobin J Ehrlich, Vedang S Uttarwar, Anny Reyes, Brianna M Paul, Carrie R McDonald
This study explored the relationships among multimodal imaging, clinical features, and language impairment in patients with left temporal lobe epilepsy (LTLE). Fourteen patients with LTLE and 26 controls underwent structural MRI, functional MRI, diffusion tensor imaging, and neuropsychological language tasks. Laterality indices were calculated for each imaging modality and a principal component (PC) was derived from language measures. Correlations were performed among imaging measures, as well as to the language PC...
July 2017: Brain and Language
https://www.readbyqxmd.com/read/28410466/history-of-surgery-for-temporal-lobe-epilepsy
#16
REVIEW
Ali A Asadi-Pooya, Cyrus Rostami
The history of epilepsy and its treatment goes back to ancient times when it included medicinal herbs, lifestyle modifications, and even surgery. Trepanation is considered the oldest surgical procedure for the treatment of epilepsy. The first series of temporal lobectomies for the treatment of drug-resistant epilepsy were reported by Penfield and Flanigin (1950). During the years since then, neuroimaging and other technologies have had remarkable and revolutionary progress. This progress has resulted in tremendous advancements in understanding the underlying causes and pathophysiology of epilepsies...
May 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28377253/implementing-functional-preoperative-mapping-in-the-clinical-routine-of-a-neurosurgical-department-technical-note
#17
Nico Sollmann, Bernhard Meyer, Sandro M Krieg
BACKGROUND: Navigated transcranial magnetic stimulation (nTMS) is increasingly being used for mapping of various brain functions and nTMS-based tractography in neurosurgical departments worldwide. When a department starts integrating nTMS data into the clinical workflow, smooth implementation in the existing hospital's infrastructure is mandatory. However, standardized approaches beyond the mapping or tractography procedures themselves have not yet been described. METHODS: To create an effective workflow for neurosurgical nTMS mapping, we present the results of our 7 years of experience and progressive integration into clinical routine...
April 1, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28397839/a-connectomic-approach-for-subcallosal-cingulate-deep-brain-stimulation-surgery-prospective-targeting-in-treatment-resistant-depression
#18
P Riva-Posse, K S Choi, P E Holtzheimer, A L Crowell, S J Garlow, J K Rajendra, C C McIntyre, R E Gross, H S Mayberg
Target identification and contact selection are known contributors to variability in efficacy across different clinical indications of deep brain stimulation surgery. A retrospective analysis of responders to subcallosal cingulate deep brain stimulation (SCC DBS) for depression demonstrated the common impact of the electrical stimulation on a stereotypic connectome of converging white matter bundles (forceps minor, uncinate fasciculus, cingulum and fronto-striatal fibers). To test the utility of a prospective connectomic approach for SCC DBS surgery, this pilot study used the four-bundle tractography 'connectome blueprint' to plan surgical targeting in 11 participants with treatment-resistant depression...
April 11, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28419879/challenging-the-myth-of-right-non-dominant-hemisphere-lessons-from-cortico-subcortical-stimulation-mapping-in-awake-surgery-and-surgical-implications
#19
REVIEW
Tatiana Vilasboas, Guillaume Herbet, Hugues Duffau
For a long time, the right hemisphere (RH) was considered as "non-dominant", especially in right-handers. In neurosurgical practice, this dogma resulted in the selection of awake procedure with language mapping only for lesions of the left "dominant" hemisphere. Conversely, surgery under general anesthesia (possibly with motor mapping) was usually proposed for right lesions. However, when objective neuropsychological assessments were performed, they frequently revealed cognitive and behavioral deficits following brain surgery, even in the RH...
April 15, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28425348/integration-of-functional-mri-and-white-matter-tractography-in-cyberknife-radiosurgery
#20
Lu Sun, Baolin Qu, Jinyuan Wang, Zhongjian Ju, Zizhong Zhang, Zhiqiang Cui, Yang Jack, Zhipei Ling, Xinguang Yu, Longsheng Pan
PURPOSE: To investigate the efficacy of the integration of functional magnetic resonance imaging and diffusion-tensor imaging tractography data into CyberKnife radiosurgery for intracranial tumor management. MATERIALS AND METHODS: Functional neuroimaging, anatomical magnetic resonance imaging, and computed tomography images of patients with brain lesions in critical areas were acquired before radiosurgery. The acquired data sets were coregistered using the MIM image fusion software module and then were imported into the CyberKnife Robotic Radiosurgery System (Multiplan 4...
January 1, 2017: Technology in Cancer Research & Treatment
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