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Andrew R Harper, Shalini Nayee, Eric J Topol
The combination of next-generation sequencing technologies and high-throughput genotyping platforms has revolutionized the pursuit of genetic variants that contribute towards disease. Furthermore, these technologies have provided invaluable insight into the genetic factors that prevent individuals from developing disease. Exploiting the evolutionary mechanisms that were designed by nature to help prevent disease is an attractive line of enquiry. Such efforts have the potential to generate a therapeutic target roadmap and rejuvenate the current drug-discovery pathway...
December 2015: Nature Reviews. Genetics
Allyson Spence, Joanna E Klementowicz, Jeffrey A Bluestone, Qizhi Tang
Regulatory T (Treg) cells are crucial players in the prevention of autoimmunity. Treg lineage commitment and functional stability are influenced by selected extracellular signals from the local environment, shaped by distinctive intracellular signaling network, and secured by their unique epigenetic profile. Recent advances in our understanding of the complex processes of Treg lineage differentiation, maintenance, and function has paved the way for developing strategies to manipulate these important cells for therapeutic benefit in many diseases...
December 2015: Current Opinion in Immunology
Arnold Han, Jacob Glanville, Leo Hansmann, Mark M Davis
No abstract text is available yet for this article.
February 2015: Nature Biotechnology
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