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RANDOMIZED CONTROLLED TRIAL
Carlos A Morillo, Jose Antonio Marin-Neto, Alvaro Avezum, Sergio Sosa-Estani, Anis Rassi, Fernando Rosas, Erick Villena, Roberto Quiroz, Rina Bonilla, Constança Britto, Felipe Guhl, Elsa Velazquez, Laura Bonilla, Brandi Meeks, Purnima Rao-Melacini, Janice Pogue, Antonio Mattos, Janis Lazdins, Anis Rassi, Stuart J Connolly, Salim Yusuf
BACKGROUND: The role of trypanocidal therapy in patients with established Chagas' cardiomyopathy is unproven. METHODS: We conducted a prospective, multicenter, randomized study involving 2854 patients with Chagas' cardiomyopathy who received benznidazole or placebo for up to 80 days and were followed for a mean of 5.4 years. The primary outcome in the time-to-event analysis was the first event of any of the components of the composite outcome of death, resuscitated cardiac arrest, sustained ventricular tachycardia, insertion of a pacemaker or implantable cardioverter-defibrillator, cardiac transplantation, new heart failure, stroke, or other thromboembolic event...
October 2015: New England Journal of Medicine
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