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By EFRAIN PAEZ Internal Medicine since 1988. Interested in all aspects of Medicine.
Zhifang Zhai, Ling Chen, Huan Yang, Jun Yan, Chunyou Wang, Jinxin Yang, Wenying Liu, Zhu Shen
BACKGROUND: The efficacy of methotrexate (MTX) varies in the treatment of psoriasis. OBJECTIVE: We sought to identify an indicator from routine pretreatment tests to predict MTX efficacy in the treatment of psoriasis. METHODS: In a retrospective analysis of 77 psoriatic patients, the correlation between MTX efficacy and pretreatment routine test results was analyzed with Spearman correlation. The potential risks were further evaluated with a linear regression model...
December 2015: Journal of the American Academy of Dermatology
Ali Tahsin Gunes, Emel Fetil, Sevgi Akarsu, Ozlem Ozbagcivan, Lale Babayeva
Psoriasis is a chronic, recurrent, immune-mediated inflammatory disease and it can be provoked or exacerbated by a variety of different environmental factors, particularly infections and drugs. In addition, a possible association between vaccination and the new onset and/or exacerbation of psoriasis has been reported by a number of different authors. The aim of this study is to investigate the effects of influenza vaccination on patients with psoriasis. Here, we report the findings from 43 patients suffering from psoriasis (clinical phenotypes as mixed guttate/plaque lesions, palmoplantar or scalp psoriasis) whose diseases had been triggered after influenza vaccination applied in the 2009-2010 season...
2015: Journal of Immunology Research
L Guenther
The scalp is involved in up to 80% of individuals with psoriasis. Eighty percent of those with scalp psoriasis experience a negative impact on quality of life. Topical treatment with corticosteroids with or without vitamin D3 analogues is the mainstay of treatment. Topical therapy most suitable for the scalp is formulated as a solution, lotion, gel, foam, spray, oil, or shampoo. Twice weekly maintenance in frequent relapsers may decrease the time to first relapse. Intralesional steroids, phototherapy and the excimer laser are occasionally used for resistant cases...
May 2015: Skin Therapy Letter
Alexander Egeberg, Lotus Mallbris, Gunnar Hilmar Gislason, Lone Skov, Peter Riis Hansen
BACKGROUND: Psoriasis and migraine are common conditions with potential overlap of pathophysiological mechanisms. Both these diseases have been associated with increased cardiovascular risk but little is known about their interplay. OBJECTIVE: We sought to investigate the link between psoriasis, and the risk of new-onset migraine, in a nationwide cohort of the Danish population. METHODS: Data on all Danish citizens aged 18 years or older from January 1, 1997, to December 31, 2011, were linked at individual-level in nationwide registers...
November 2015: Journal of the American Academy of Dermatology
Anastasios Kallianos, Paul Zarogoulidis, Fotini Ampatzoglou, Georgia Trakada, Elias Gialafos, Georgia Pitsiou, Athanasia Pataka, Lemonia Veletza, Konstantinos Zarogoulidis, Wolfgang Hohenforst-Schmidt, Dimitris Petridis, Ioannis Kioumis, Aggeliki Rapti
INTRODUCTION: Pulmonary function tests (PFTs) do not always predict functional limitations during exercise in sarcoidosis. Cardiopulmonary exercise testing (CPET) may facilitate the recognition of exercise intolerance in these patients. AIM: As relevant data in sarcoid patients are limited, the aim of the study reported here was to assess exercise capacity impairment during a maximal CPET and to evaluate potential correlations with PFT measurements and radiological stages of the disease...
2015: Patient Preference and Adherence
Patrick Fleming, John Kraft, Wayne P Gulliver, Charles Lynde
BACKGROUND: Psoriasis is a chronic inflammatory disease associated with obesity. The increased production of adipocytokines in central adiposity contributes to the systemic inflammation of obesity and perhaps to psoriasis. OBJECTIVE: The objective of this systematic review is to determine the association of obesity with psoriasis severity. METHODS: We searched PubMed, EMBASE, and Cochrane Database for English-language papers involving human subjects for all years...
September 2015: Journal of Cutaneous Medicine and Surgery
Lacey Vence, Amanda Schmitt, Charles E Meadows, Todd Gress
Guttate psoriasis is a less common form of psoriasis. It manifests with numerous small, teardrop shaped, scaly plaques on the trunk and extremities. The etiology includes both environmental and genetic factors. It commonly arises 3-4 weeks following a beta hemolytic streptococcal infection. In some cases, it may be misdiagnosed as an allergy to the antibiotics being used to treat the streptococcal infection. The treatment of guttate psoriasis can vary by severity, but the mainstay treatment includes photo therapy and topical steroids...
July 2015: West Virginia Medical Journal
Satveer K Mahil
No abstract text is available yet for this article.
July 2015: Journal of Clinical and Aesthetic Dermatology
Jessica M Donigan
No abstract text is available yet for this article.
July 2015: Journal of Clinical and Aesthetic Dermatology
Wai Sze Agnes Chan, Shang-Ian Tee, Nisha Su Yien Chandran, Jiun Yit Pan
Non-tuberculous mycobacteria (NTM) are a group of environmental pathogens, which cause a broad spectrum of disease. The incidence of NTM infection is increasing, especially in immunocompromized patients. The past three decades also saw a rapid increase in the incidence of NTM infection involving otherwise healthy subjects. We report a case of cutaneous NTM infection in a 79-year-old Chinese woman, who was receiving methotrexate for psoriasis. Mycobacterial culture grew Mycobacterium abscessus, and the lesions cleared with a combination of oral clarithromycin, ciprofloxacin and doxycycline...
May 21, 2015: Dermatology Reports
Alexander Egeberg, Usman Khalid, Gunnar Hilmar Gislason, Lotus Mallbris, Lone Skov, Peter Riis Hansen
IMPORTANCE: Psoriasis, psoriatic arthritis, and uveitis are inflammatory disorders with significant overlap in their inflammatory pathways. Limited evidence is available about the relationship between psoriatic disease and uveitis. OBJECTIVE: To investigate the potential bidirectional relationship between psoriatic disease, including psoriasis and psoriatic arthritis, and uveitis. DESIGN, SETTING, AND PARTICIPANTS: We performed a nationwide cohort study of the Danish population from January 1, 1997, through December 31, 2011...
November 2015: JAMA Dermatology
Jamie L Harden, James G Krueger, Anne M Bowcock
Psoriasis vulgaris is a common, chronic inflammatory skin disease with a complex etiology involving genetic risk factors and environmental triggers. Here we describe the many known genetic predispositions of psoriasis with respect to immune genes and their encoded pathways in psoriasis susceptibility. These genes span an array of functions that involve antigen presentation (HLA-Cw6, ERAP1, ERAP2, MICA), the IL-23 axis (IL12Bp40, IL23Ap19, IL23R, JAK2, TYK2), T-cell development and T-cells polarization (RUNX1, RUNX3, STAT3, TAGAP, IL4, IL13), innate immunity (CARD14, c-REL, TRAF3IP2, DDX58, IFIH1), and negative regulators of immune responses (TNIP1, TNFAIP3, NFKBIA, ZC3H12C, IL36RN, SOCS1)...
November 2015: Journal of Autoimmunity
Emily Osier, Barbara Gomez, Lawrence F Eichenfield
Plaque psoriasis can begin early in life and negatively affect quality of life. Topical agents are generally recommended as first-line therapy for plaque psoriasis. The synergy of a vitamin D analog and a steroid in a topical fixed-combination formulation provides more favorable effectiveness and tolerability as compared with either agent alone. The safety and effectiveness of a once-daily calcipotriene/betamethasone dipropionate topical suspension have been established in children 12 to 17 years of age with scalp plaque psoriasis...
July 2015: Journal of Clinical and Aesthetic Dermatology
Anthony A Gaspari, Stephen Tyring
The development of effective and well-tolerated biologic therapies has advanced the management of psoriasis by enabling clinicians to treat underlying disease mechanisms. Biologics approved for the treatment of moderate-to-severe psoriasis include three tumor necrosis factor alpha inhibitors and an interleukin-12/interleukin-23 inhibitor. The establishment of the immunological basis of psoriasis has led to the development of biologic agents targeting specific downstream mediators in the psoriatic cascade. These drugs inhibit cytokines and cytokine signaling/transcription mediators like interleukin-17, which plays an important role in immunopathogenesis...
July 2015: Dermatologic Therapy
Malcolm D Smith
No abstract text is available yet for this article.
July 21, 2015: Annals of Internal Medicine
Anna Wolska-Bułach, Lucyna Woźnicka-Leśkiewicz, Arkadiusz Niklas, Karolina Niklas, Andrzej Tykarski
No abstract text is available yet for this article.
2015: Kardiologia Polska
Christine S Ahn, Emily H Dothard, Michael L Garner, Steven R Feldman, William W Huang
BACKGROUND: Safety profiles of systemic biologic agents for the treatment of psoriasis and psoriatic arthritis (PsA) encompass a wide spectrum of adverse events. To date, no uniform evidence-based guidelines exist regarding screening and monitoring patients who are undergoing biologic therapy. OBJECTIVE: We sought to identify studies evaluating screening and monitoring tests in the treatment of psoriasis and PsA with systemic biologic agents, and to propose evidence-based practical guidelines...
September 2015: Journal of the American Academy of Dermatology
Kathleen E Gilbert, Iviensan F Manalo, Jashin J Wu
No abstract text is available yet for this article.
August 2015: Journal of the American Academy of Dermatology
Ana Batalla, Daniel González-Fernández, Leire González-Lara, Teresa Abalde, Laura Salgado-Boquete, Rubén Queiro-Silva, Eliecer Coto, Pablo Coto-Segura
No abstract text is available yet for this article.
August 2015: Journal of the American Academy of Dermatology
Molly A Hinshaw, Adam Rubin
inflammatory disorders of the nail unit are frequently encountered in clinical medicine and are a cause of significant morbidity. Psoriasis, lichen planus, chronic paronychia, and trachyonychia will be discussed. An approach to diagnosis and management of these disorders requires knowledge of nail unit anatomy, consideration of associated systemic manifestations, and patient education with respect to prognosis and management of factors that will maximize disease improvement. The nail unit responds with a limited number of signs to disparate clinical entities such that there is some overlap in clinical presentation between inflammatory conditions...
June 2015: Seminars in Cutaneous Medicine and Surgery
2015-08-30 19:42:48
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