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Deren Wang, Bian Liu, Wendan Tao, Zilong Hao, Ming Liu
BACKGROUND: Fibrates are a class of drugs characterised by mainly lowering high triglyceride, raising high-density lipoprotein (HDL) cholesterol, and lowering the small dense fraction of low-density lipoprotein (LDL) cholesterol. Their efficacy for secondary prevention of serious vascular events is unclear, and to date no systematic review focusing on secondary prevention has been undertaken. OBJECTIVES: To assess the efficacy and safety of fibrates for the prevention of serious vascular events in people with previous cardiovascular disease (CVD), including coronary heart disease and stroke...
2015: Cochrane Database of Systematic Reviews
Vincent Auffret, Guillaume Leurent, Martine Gilard, Jean-Philippe Hacot, Emmanuelle Filippi, Régis Delaunay, Antoine Rialan, Gilles Rouault, Philippe Druelles, Philippe Castellant, Isabelle Coudert, Bertrand Boulanger, Josiane Treuil, Emilie Bot, Marc Bedossa, Dominique Boulmier, Marielle Le Guellec, Erwan Donal, Hervé Le Breton
BACKGROUND: Acute heart failure (AHF) complicating ST-segment elevation myocardial infarction (STEMI) is recognized as an ominous complication. Previous studies mostly reported outcomes of heterogeneous, non-contemporary population. Moreover, few studies assessed the prognosis of AHF according to its timing. This study evaluated incidence, predictors and impact of AHF according to its timing in a homogeneous STEMI patients population treated by primary percutaneous coronary intervention (pPCI)...
October 15, 2016: International Journal of Cardiology
Anju Bhardwaj, Mark E Dunlap
Despite major advances that have led to effective therapeutic modalities for the treatment of heart failure (HF), this syndrome has continued to be a staggering health problem associated with significant mortality and morbidity. The increasing number of hospital admissions and readmissions related to acute HF continues to pose a fiscal challenge leading to constant interest in development of novel approaches. These point to multiple areas of unmet needs especially in acute HF, thus, necessitating further efforts to develop novel strategies for prevention and treatment of acute HF...
October 2015: Current Treatment Options in Cardiovascular Medicine
G Michael Felker, Kerry L Lee, David A Bull, Margaret M Redfield, Lynne W Stevenson, Steven R Goldsmith, Martin M LeWinter, Anita Deswal, Jean L Rouleau, Elizabeth O Ofili, Kevin J Anstrom, Adrian F Hernandez, Steven E McNulty, Eric J Velazquez, Abdallah G Kfoury, Horng H Chen, Michael M Givertz, Marc J Semigran, Bradley A Bart, Alice M Mascette, Eugene Braunwald, Christopher M O'Connor
BACKGROUND: Loop diuretics are an essential component of therapy for patients with acute decompensated heart failure, but there are few prospective data to guide their use. METHODS: In a prospective, double-blind, randomized trial, we assigned 308 patients with acute decompensated heart failure to receive furosemide administered intravenously by means of either a bolus every 12 hours or continuous infusion and at either a low dose (equivalent to the patient's previous oral dose) or a high dose (2...
March 3, 2011: New England Journal of Medicine
Gustavo Freb Polenz, Tiago Luiz Luz Leiria, Vidal Essebag, Marcelo Lapa Kruse, Leonardo Martins Pires, Thaize Brisolara Nogueira, Raphael Boesche Guimarães, Roberto Tofani Santanna, Gustavo Glotz DE Lima
BACKGROUND: New evidence suggests that the CHA(2)DS(2)VASc (congestive heart failure, hypertension [HTN], age, diabetes, stroke, vascular disease, and female gender) score may be a reliable tool to predict the risk of thromboembolic events in patients without documented atrial fibrillation (AF). METHODS: We performed a prospective cohort study of outpatients without AF or flutter, who were not using oral anticoagulation. Clinical characteristics were assessed and patients were stratified according to the CHA(2)DS(2)VASc score...
December 2015: Pacing and Clinical Electrophysiology: PACE
Olga Toleva, Quazi Ibrahim, Neil Brass, Sunil Sookram, Robert Welsh
BACKGROUND: Management of elderly patients with ST elevation myocardial infarction (STEMI) is challenging and they are under-represented in trials. Accordingly, we analysed reperfusion strategies and their effectiveness in patients with STEMI ≥75 years compared to <75 years within a comprehensive inclusive registry. METHODS: Consecutive patients with STEMI admitted to hospital and tracked within a regional registry (2006-2011) were analysed comparing reperfusion strategy (primary percutaneous coronary intervention (PPCI), fibrinolysis and no reperfusion) between patients ≥75 vs <75 years old as well as across the reperfusion strategies in those ≥75 years...
2015: Open Heart
David C Goff, Donald M Lloyd-Jones, Glen Bennett, Sean Coady, Ralph B D'Agostino, Raymond Gibbons, Philip Greenland, Daniel T Lackland, Daniel Levy, Christopher J O'Donnell, Jennifer G Robinson, J Sanford Schwartz, Susan T Shero, Sidney C Smith, Paul Sorlie, Neil J Stone, Peter W F Wilson, Harmon S Jordan, Lev Nevo, Janusz Wnek, Jeffrey L Anderson, Jonathan L Halperin, Nancy M Albert, Biykem Bozkurt, Ralph G Brindis, Lesley H Curtis, David DeMets, Judith S Hochman, Richard J Kovacs, E Magnus Ohman, Susan J Pressler, Frank W Sellke, Win-Kuang Shen, Sidney C Smith, Gordon F Tomaselli
No abstract text is available yet for this article.
June 24, 2014: Circulation
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