collection
https://read.qxmd.com/read/30864748/sustained-blood-pressure-control-and-coronary-heart-disease-stroke-heart-failure-and-mortality-an-observational-analysis-of-allhat
#1
JOURNAL ARTICLE
C Barrett Bowling, Barry R Davis, Alison Luciano, Lara M Simpson, Richard Sloane, Carl F Pieper, Paula T Einhorn, Suzanne Oparil, Paul Muntner
Achieving blood pressure (BP) control is associated with lower cardiovascular disease (CVD) risk, but less is known about CVD risk associated with sustained BP control over time. This observational analysis of the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) was restricted to participants with four to seven visits with systolic BP (SBP) measurements during a 22-month period (n = 24 309). The authors categorized participants as having sustained BP control (SBP < 140 mm Hg) at 100%, 75% to <100%, 50% to <75%, and <50% of visits during this period...
April 2019: Journal of Clinical Hypertension
https://read.qxmd.com/read/30712900/efficacy-and-safety-of-statin-therapy-in-older-people-a-meta-analysis-of-individual-participant-data-from-28-randomised-controlled-trials
#2
JOURNAL ARTICLE
(no author information available yet)
BACKGROUND: Statin therapy has been shown to reduce major vascular events and vascular mortality in a wide range of individuals, but there is uncertainty about its efficacy and safety among older people. We undertook a meta-analysis of data from all large statin trials to compare the effects of statin therapy at different ages. METHODS: In this meta-analysis, randomised trials of statin therapy were eligible if they aimed to recruit at least 1000 participants with a scheduled treatment duration of at least 2 years...
February 2, 2019: Lancet
https://read.qxmd.com/read/30580575/statin-safety-and-associated-adverse-events-a-scientific-statement-from-the-american-heart-association
#3
REVIEW
Connie B Newman, David Preiss, Jonathan A Tobert, Terry A Jacobson, Robert L Page, Larry B Goldstein, Clifford Chin, Lisa R Tannock, Michael Miller, Geetha Raghuveer, P Barton Duell, Eliot A Brinton, Amy Pollak, Lynne T Braun, Francine K Welty
One in 4 Americans >40 years of age takes a statin to reduce the risk of myocardial infarction, ischemic stroke, and other complications of atherosclerotic disease. The most effective statins produce a mean reduction in low-density lipoprotein cholesterol of 55% to 60% at the maximum dosage, and 6 of the 7 marketed statins are available in generic form, which makes them affordable for most patients. Primarily using data from randomized controlled trials, supplemented with observational data where necessary, this scientific statement provides a comprehensive review of statin safety and tolerability...
February 2019: Arteriosclerosis, Thrombosis, and Vascular Biology
https://read.qxmd.com/read/30198808/ldl-c-does-not-cause-cardiovascular-disease-a-comprehensive-review-of-the-current-literature
#4
REVIEW
Uffe Ravnskov, Michel de Lorgeril, David M Diamond, Rokuro Hama, Tomohito Hamazaki, Björn Hammarskjöld, Niamh Hynes, Malcolm Kendrick, Peter H Langsjoen, Luca Mascitelli, Kilmer S McCully, Harumi Okuyama, Paul J Rosch, Tore Schersten, Sherif Sultan, Ralf Sundberg
For half a century, a high level of total cholesterol (TC) or low-density lipoprotein cholesterol (LDL-C) has been considered to be the major cause of atherosclerosis and cardiovascular disease (CVD), and statin treatment has been widely promoted for cardiovascular prevention. However, there is an increasing understanding that the mechanisms are more complicated and that statin treatment, in particular when used as primary prevention, is of doubtful benefit. Areas covered: The authors of three large reviews recently published by statin advocates have attempted to validate the current dogma...
October 2018: Expert Review of Clinical Pharmacology
https://read.qxmd.com/read/30763510/lifetime-risk-of-stroke-and-coronary-heart-disease-deaths-according-to-blood-pressure-level-epoch-japan-evidence-for-cardiovascular-prevention-from-observational-cohorts-in-japan
#5
JOURNAL ARTICLE
Michihiro Satoh, Takayoshi Ohkubo, Kei Asayama, Yoshitaka Murakami, Daisuke Sugiyama, Michiko Yamada, Shigeyuki Saitoh, Kiyomi Sakata, Fujiko Irie, Toshimi Sairenchi, Shizukiyo Ishikawa, Masahiko Kiyama, Hirofumi Ohnishi, Katsuyuki Miura, Yutaka Imai, Hirotsugu Ueshima, Tomonori Okamura
Lifetime risk (LTR) provides an absolute risk assessment during the remainder of one’s life. Few studies have focused on the LTRs of stroke and coronary heart disease (CHD), categorized by fine blood pressure in Asian populations. We aimed to assess it using a large database of a meta-analysis with the individual participant data. The present metaanalysis included 107 737 Japanese (42.4% men; mean age, 55.1 years) from 13 cohorts. During the mean follow-up of 15.2±5.3 years (1 559 136 person-years), 1922 died from stroke and 913 from CHD...
January 2019: Hypertension
https://read.qxmd.com/read/30651799/effect-of-rosuvastatin-on-vascular-endothelial-functions-and-inflammatory-factors-of-patients-with-type-2-diabetes-mellitus-and-coronary-heart-disease
#6
JOURNAL ARTICLE
Gang Ma, Shuting Bi
Effects of rosuvastatin on vascular endothelial functions and inflammatory factors of patients with type 2 diabetes mellitus and coronary heart disease were investigated. Eighty patients with type 2 diabetes mellitus and coronary heart disease, who were admitted and treated in Center hospital of Zibo from January 2016 to January 2017, were selected and divided into observation group (n=40) and control group (n=40) by the random number table; symptomatic and supporting therapy, including use of metformin, captopril, asprin and levocarnitine, was used in control group while rosuvastatin was adopted in observation group in addition to the symptomatic and supporting therapy...
January 2019: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/30826740/atrial-fibrillation-and-stroke-a-practical-guide
#7
REVIEW
Jonathan Gordon Best, Robert Bell, Mohammed Haque, Arvind Chandratheva, David John Werring
Neurologists and stroke physicians will be familiar with atrial fibrillation as a major cause of ischaemic stroke, and the role of anticoagulation in preventing cardioembolic stroke. However, making decisions about anticoagulation for individual patients remains a difficult area of clinical practice, balancing the serious risk of ischaemic stroke against that of major bleeding, particularly intracranial haemorrhage. Atrial fibrillation management requires interdisciplinary collaboration with colleagues in cardiology and haematology...
June 2019: Practical Neurology
https://read.qxmd.com/read/30852913/cardiorenal-syndrome-classification-pathophysiology-diagnosis-and-treatment-strategies-a-scientific-statement-from-the-american-heart-association
#8
JOURNAL ARTICLE
Janani Rangaswami, Vivek Bhalla, John E A Blair, Tara I Chang, Salvatore Costa, Krista L Lentine, Edgar V Lerma, Kenechukwu Mezue, Mark Molitch, Wilfried Mullens, Claudio Ronco, W H Wilson Tang, Peter A McCullough
Cardiorenal syndrome encompasses a spectrum of disorders involving both the heart and kidneys in which acute or chronic dysfunction in 1 organ may induce acute or chronic dysfunction in the other organ. It represents the confluence of heart-kidney interactions across several interfaces. These include the hemodynamic cross-talk between the failing heart and the response of the kidneys and vice versa, as well as alterations in neurohormonal markers and inflammatory molecular signatures characteristic of its clinical phenotypes...
April 16, 2019: Circulation
https://read.qxmd.com/read/30646102/risk-factors-associated-with-major-cardiovascular-events-1-year-after-acute-myocardial-infarction
#9
JOURNAL ARTICLE
Yun Wang, Jing Li, Xin Zheng, Zihan Jiang, Shuang Hu, Rishi K Wadhera, Xueke Bai, Jiapeng Lu, Qianying Wang, Yetong Li, Chaoqun Wu, Chao Xing, Sharon-Lise Normand, Harlan M Krumholz, Lixin Jiang
Importance: Patients who survive acute myocardial infarction (AMI) have a high risk of subsequent major cardiovascular events. Efforts to identify risk factors for recurrence have primarily focused on the period immediately following AMI admission. Objectives: To identify risk factors and develop and evaluate a risk model that predicts 1-year cardiovascular events after AMI. Design, Setting, and Participants: Prospective cohort study. Patients with AMI (n = 4227), aged 18 years or older, discharged alive from 53 acute-care hospitals across China from January 1, 2013, to July 17, 2014...
August 3, 2018: JAMA Network Open
https://read.qxmd.com/read/30768197/association-between-push-up-exercise-capacity-and-future-cardiovascular-events-among-active-adult-men
#10
JOURNAL ARTICLE
Justin Yang, Costas A Christophi, Andrea Farioli, Dorothee M Baur, Steven Moffatt, Terrell W Zollinger, Stefanos N Kales
IMPORTANCE: Cardiovascular disease (CVD) remains the leading cause of mortality worldwide. Robust evidence indicates an association of increased physical fitness with a lower risk of CVD events and improved longevity; however, few have studied simple, low-cost measures of functional status. OBJECTIVE: To evaluate the association between push-up capacity and subsequent CVD event incidence in a cohort of active adult men. DESIGN, SETTING, AND PARTICIPANTS: Retrospective longitudinal cohort study conducted between January 1, 2000, and December 31, 2010, in 1 outpatient clinics in Indiana of male firefighters aged 18 years or older...
February 1, 2019: JAMA Network Open
https://read.qxmd.com/read/30586736/potential-cardiovascular-disease-events-prevented-with-adoption-of-the-2017-american-college-of-cardiology-american-heart-association-blood-pressure-guideline
#11
COMPARATIVE STUDY
Adam P Bress, Lisandro D Colantonio, Richard S Cooper, Holly Kramer, John N Booth, Michelle C Odden, Kirsten Bibbins-Domingo, Daichi Shimbo, Paul K Whelton, Emily B Levitan, George Howard, Brandon K Bellows, Dawn Kleindorfer, Monika M Safford, Paul Muntner, Andrew E Moran
BACKGROUND: Over 10 years, achieving and maintaining 2017 ACC/AHA guideline goals could prevent 3.0 million (UR, 1.1-5.1 million), 0.5 million (UR, 0.2-0.7 million), and 1.4 million (UR, 0.6-2.0 million) cardiovascular disease (CVD) events compared with maintaining current blood pressure (BP) levels, achieving 2003 Seventh Joint National Committee Report goals, and achieving 2014 Eighth Joint National Committee goals, respectively. We estimated the number of cardiovascular disease events prevented and treatment-related serious adverse events incurred over 10 years among US adults with hypertension by achieving 2017 ACC/AHA guideline-recommended BP goals compared with (1) current BP levels, (2) achieving 2003 Seventh Joint National Committee Report BP goals, and (3) achieving 2014 Eighth Joint National Committee panel member report BP goals...
January 2, 2019: Circulation
https://read.qxmd.com/read/30686041/2019-aha-acc-hrs-focused-update-of-the-2014-aha-acc-hrs-guideline-for-the-management-of-patients-with-atrial-fibrillation-a-report-of-the-american-college-of-cardiology-american-heart-association-task-force-on-clinical-practice-guidelines-and-the-heart-rhythm
#12
REVIEW
Craig T January, L Samuel Wann, Hugh Calkins, Lin Y Chen, Joaquin E Cigarroa, Joseph C Cleveland, Patrick T Ellinor, Michael D Ezekowitz, Michael E Field, Karen L Furie, Paul A Heidenreich, Katherine T Murray, Julie B Shea, Cynthia M Tracy, Clyde W Yancy
No abstract text is available yet for this article.
July 9, 2019: Circulation
https://read.qxmd.com/read/30814385/sleep-disordered-breathing-and-cardiovascular-diseases
#13
REVIEW
Akiomi Yoshihisa, Yasuchika Takeishi
Sleep disordered breathing (SDB), which causes sleep deprivation, intermittent hypoxia, and negative intrathoracic pressure swings, can be accompanied by other harmful pathophysiologies relating to cardiovascular diseases (CVD), including sudden death, atrial fibrillation, stroke, and coronary artery disease leading to heart failure. Continuous positive airway pressure (CPAP) therapy for SDB has been reported to provide favorable effects such as lowered systemic blood pressure and improved endothelial function...
April 1, 2019: Journal of Atherosclerosis and Thrombosis
https://read.qxmd.com/read/30624365/impact-of-early-initiation-of-antihypertensive-medications-for-patients-with-hypertension-or-elevated-blood-pressure
#14
JOURNAL ARTICLE
Xue Han, Jeff McCombs, Michelle Chu, J Samantha Dougherty, D Steven Fox
OBJECTIVES: The 2017 American College of Cardiology/American Heart Association High Blood Pressure Guidelines lowered high blood pressure (BP) threshold, recommending earlier treatment to prevent cardiovascular disease. This study estimated the impact of initiating early antihypertensive medications on the risk of acute myocardial infarction (AMI), stroke, death, and on healthcare costs in patients potentially qualifying for antihypertensive treatment under the 2017 guidelines. METHODS: High-risk patients qualifying for antihypertensive medications under the 2017 guidelines were identified using Optum data...
June 2019: Journal of Hypertension
https://read.qxmd.com/read/30616610/nmr-based-metabolomics-identifies-patients-at-high-risk-of-death-within-two-years-after-acute-myocardial-infarction-in-the-ami-florence-ii-cohort
#15
JOURNAL ARTICLE
Alessia Vignoli, Leonardo Tenori, Betti Giusti, Panteleimon G Takis, Serafina Valente, Nazario Carrabba, Daniela Balzi, Alessandro Barchielli, Niccolò Marchionni, Gian Franco Gensini, Rossella Marcucci, Claudio Luchinat, Anna Maria Gori
BACKGROUND: Risk stratification and management of acute myocardial infarction patients continue to be challenging despite considerable efforts made in the last decades by many clinicians and researchers. The aim of this study was to investigate the metabolomic fingerprint of acute myocardial infarction using nuclear magnetic resonance spectroscopy on patient serum samples and to evaluate the possible role of metabolomics in the prognostic stratification of acute myocardial infarction patients...
January 7, 2019: BMC Medicine
https://read.qxmd.com/read/30355745/angiotensin-converting-enzyme-inhibitors-and-risk-of-lung-cancer-population-based-cohort-study
#16
COMPARATIVE STUDY
Blánaid M Hicks, Kristian B Filion, Hui Yin, Lama Sakr, Jacob A Udell, Laurent Azoulay
OBJECTIVE: To determine whether the use of angiotensin converting enzyme inhibitors (ACEIs), compared with use of angiotensin receptor blockers, is associated with an increased risk of lung cancer. DESIGN: Population based cohort study. SETTING: United Kingdom Clinical Practice Research Datalink. PARTICIPANTS: A cohort of 992 061 patients newly treated with antihypertensive drugs between 1 January 1995 and 31 December 2015 was identified and followed until 31 December 2016...
October 24, 2018: BMJ: British Medical Journal
https://read.qxmd.com/read/24976920/cardiomyopathies-evolution-of-pathogenesis-concepts-and-potential-for-new-therapies
#17
REVIEW
Hamayak Sisakian
Cardiomyopathies are defined as diseases of the myocardium with associated structural and functional abnormalities. Knowledge of these pathologies for a long period was not clear in clinical practice due to uncertainties regarding definition, classification and clinical diagnosis. In recent decades, major advances have been made in the understanding of the molecular and genetic issues, pathophysiology, and clinical and radiological assessment of the diseases. Progress has been made also in management of several types of cardiomyopathy...
June 26, 2014: World Journal of Cardiology
https://read.qxmd.com/read/27672202/correction-to-2016-acc-aha-hfsa-focused-update-on-new-pharmacological-therapy-for-heart-failure-an-update-of-the-2013-accf-aha-guideline-for-the-management-of-heart-failure-a-report-of-the-american-college-of-cardiology-foundation-american-heart-association
#18
JOURNAL ARTICLE
https://read.qxmd.com/read/26497361/fibrates-for-secondary-prevention-of-cardiovascular-disease-and-stroke
#19
REVIEW
Deren Wang, Bian Liu, Wendan Tao, Zilong Hao, Ming Liu
BACKGROUND: Fibrates are a class of drugs characterised by mainly lowering high triglyceride, raising high-density lipoprotein (HDL) cholesterol, and lowering the small dense fraction of low-density lipoprotein (LDL) cholesterol. Their efficacy for secondary prevention of serious vascular events is unclear, and to date no systematic review focusing on secondary prevention has been undertaken. OBJECTIVES: To assess the efficacy and safety of fibrates for the prevention of serious vascular events in people with previous cardiovascular disease (CVD), including coronary heart disease and stroke...
October 25, 2015: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/27409570/incidence-timing-predictors-and-impact-of-acute-heart-failure-complicating-st-segment-elevation-myocardial-infarction-in-patients-treated-by-primary-percutaneous-coronary-intervention
#20
JOURNAL ARTICLE
Vincent Auffret, Guillaume Leurent, Martine Gilard, Jean-Philippe Hacot, Emmanuelle Filippi, Régis Delaunay, Antoine Rialan, Gilles Rouault, Philippe Druelles, Philippe Castellant, Isabelle Coudert, Bertrand Boulanger, Josiane Treuil, Emilie Bot, Marc Bedossa, Dominique Boulmier, Marielle Le Guellec, Erwan Donal, Hervé Le Breton
BACKGROUND: Acute heart failure (AHF) complicating ST-segment elevation myocardial infarction (STEMI) is recognized as an ominous complication. Previous studies mostly reported outcomes of heterogeneous, non-contemporary population. Moreover, few studies assessed the prognosis of AHF according to its timing. This study evaluated incidence, predictors and impact of AHF according to its timing in a homogeneous STEMI patients population treated by primary percutaneous coronary intervention (pPCI)...
October 15, 2016: International Journal of Cardiology
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