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Agnieszka Mielczarek, Jarosław Damian Kasprzak, Andrzej Marcinkiewicz, Małgorzata Kurpesa, Barbara Uznańska-Loch, Karina Wierzbowska-Drabik
Takotsubo cardiomiopathy (TTC) (known also as "ampulla cardiomyopathy," "apical ballooning" or "broken heart syndrome") is connected with a temporary systolic left ventricular dysfunction without the culprit coronary lesion. Takotsubo cardiomyopathy was first described in 1990 in Japan after octopus trapping pot with a round bottom and narrow neck similar in shape to left ventriculogram in TTC patients. The occurrence of TTC is usually precipitated by a stressful event with a clinical presentation mimicking myocardial infarction: chest pain, ST-T segment elevation or T-wave inversion, a rise in cardiac troponin, and contractility abnormalities in echocardiography...
2015: International Journal of Occupational Medicine and Environmental Health
Antje-Christin Deppe, Wasim Arbash, Elmar W Kuhn, Ingo Slottosch, Maximilian Scherner, Oliver J Liakopoulos, Yeong-Hoon Choi, Thorsten Wahlers
In the present systematic review with meta-analysis, we sought to determine the current strength of evidence for or against off-pump and on-pump coronary artery bypass grafting (CABG) with regard to hard clinical end-points, graft patency and cost-effectiveness. We performed a meta-analysis of only randomized controlled trials (RCT) which reported at least one of the desired end-points including: (i) major adverse cardiac and cerebrovascular events (MACCE), (ii) all-cause mortality, (iii) myocardial infarction, (iv) cerebrovascular accident, (v) repeat revascularization, (vi) graft patency and (vii) cost-effectiveness...
April 2016: European Journal of Cardio-thoracic Surgery
Laura Morata, Josep Mensa, Alex Soriano
Gram-positive cocci are the most frequent aetiology of community and nosocomially bacterial acquired infections. The prevalence of multidrug-resistant gram-positive bacteria is increasing and is associated with high morbidity and mortality. New antibiotics will be available in the European market during the next months. This revision is focused on lipoglycopeptides, new cephalosporins active against methicillin-resistant Staphylococcus aureus (MRSA) and the new oxazolidinone, tedizolid. The purpose of this review is to describe their in vitro activity, pharmacokinetic and pharmacodynamic characteristics, and experience from clinical trials...
October 2015: Current Opinion in Pharmacology
Vito Mannacio, Pascal Meier, Anita Antignano, Luigi Di Tommaso, Vincenzo De Amicis, Carlo Vosa
OBJECTIVE: An increasing number of patients presenting for urgent coronary surgery have been exposed to clopidogrel, which constitutes a risk of bleeding and related events. Based on the wide variability in clopidogrel response and platelet function recovery after cessation, we evaluated the role of point-of-care platelet function testing to define the optimal time for off-pump coronary artery bypass graft (CABG) surgery in a case-control study. METHODS: Three equally matched groups (300 patients in total) undergoing isolated off-pump CABG for acute coronary syndrome were compared...
October 2014: Journal of Thoracic and Cardiovascular Surgery
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