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106 papers 0 to 25 followers
https://www.readbyqxmd.com/read/25005654/how-to-read-a-systematic-review-and-meta-analysis-and-apply-the-results-to-patient-care-users-guides-to-the-medical-literature
#1
Mohammad Hassan Murad, Victor M Montori, John P A Ioannidis, Roman Jaeschke, P J Devereaux, Kameshwar Prasad, Ignacio Neumann, Alonso Carrasco-Labra, Thomas Agoritsas, Rose Hatala, Maureen O Meade, Peter Wyer, Deborah J Cook, Gordon Guyatt
Clinical decisions should be based on the totality of the best evidence and not the results of individual studies. When clinicians apply the results of a systematic review or meta-analysis to patient care, they should start by evaluating the credibility of the methods of the systematic review, ie, the extent to which these methods have likely protected against misleading results. Credibility depends on whether the review addressed a sensible clinical question; included an exhaustive literature search; demonstrated reproducibility of the selection and assessment of studies; and presented results in a useful manner...
July 2014: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27733354/robins-i-a-tool-for-assessing-risk-of-bias-in-non-randomised-studies-of-interventions
#2
Jonathan Ac Sterne, Miguel A Hernán, Barnaby C Reeves, Jelena Savović, Nancy D Berkman, Meera Viswanathan, David Henry, Douglas G Altman, Mohammed T Ansari, Isabelle Boutron, James R Carpenter, An-Wen Chan, Rachel Churchill, Jonathan J Deeks, Asbjørn Hróbjartsson, Jamie Kirkham, Peter Jüni, Yoon K Loke, Theresa D Pigott, Craig R Ramsay, Deborah Regidor, Hannah R Rothstein, Lakhbir Sandhu, Pasqualina L Santaguida, Holger J Schünemann, Beverly Shea, Ian Shrier, Peter Tugwell, Lucy Turner, Jeffrey C Valentine, Hugh Waddington, Elizabeth Waters, George A Wells, Penny F Whiting, Julian Pt Higgins
No abstract text is available yet for this article.
October 12, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27758792/beyond-open-data-realising-the-health-benefits-of-sharing-data
#3
Elizabeth Pisani, Peter Aaby, J Gabrielle Breugelmans, David Carr, Trish Groves, Michelle Helinski, Dorcas Kamuya, Steven Kern, Katherine Littler, Vicki Marsh, Souleymane Mboup, Laura Merson, Osman Sankoh, Micaela Serafini, Martin Schneider, Vreni Schoenenberger, Philippe J Guerin
No abstract text is available yet for this article.
October 10, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27777221/is-this-trial-misreported-truth-seeking-in-the-burgeoning-age-of-trial-transparency
#4
Peter Doshi
No abstract text is available yet for this article.
October 24, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27777223/consort-2010-statement-extension-to-randomised-pilot-and-feasibility-trials
#5
Sandra M Eldridge, Claire L Chan, Michael J Campbell, Christine M Bond, Sally Hopewell, Lehana Thabane, Gillian A Lancaster
No abstract text is available yet for this article.
October 24, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27789483/very-large-treatment-effects-in-randomised-trials-as-an-empirical-marker-to-indicate-whether-subsequent-trials-are-necessary-meta-epidemiological-assessment
#6
Myura Nagendran, Tiago V Pereira, Grace Kiew, Douglas G Altman, Mahiben Maruthappu, John P A Ioannidis, Peter McCulloch
OBJECTIVE:  To examine whether a very large effect (VLE; defined as a relative risk of ≤0.2 or ≥5) in a randomised trial could be an empirical marker that subsequent trials are unnecessary. DESIGN:  Meta-epidemiological assessment of existing published data on randomised trials. DATA SOURCES:  Cochrane Database of Systematic Reviews (2010, issue 7) with data on subsequent large trials updated to 2015, issue 12. ELIGIBILITY CRITERIA:  All binary outcome forest plots were selected, which contained an index randomised trial with a VLE that was nominally statistically significant (P<0...
October 27, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27797786/towards-evidence-based-research
#7
Hans Lund, Klara Brunnhuber, Carsten Juhl, Karen Robinson, Marlies Leenaars, Bertil F Dorch, Gro Jamtvedt, Monica W Nortvedt, Robin Christensen, Iain Chalmers
No abstract text is available yet for this article.
October 21, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27815253/nearly-half-of-all-trials-run-by-major-sponsors-in-past-decade-are-unpublished
#8
Gareth Iacobucci
No abstract text is available yet for this article.
November 4, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27779514/patient-eligibility-for-randomized-controlled-trials-in-critical-care-medicine-an-international-two-center-observational-study
#9
Ryan M J Ivie, Emily A Vail, Hannah Wunsch, Monica P Goldklang, Robert Fowler, Vivek K Moitra
OBJECTIVE: We conducted this study to determine the generalizability of information gained from randomized controlled trials in critically ill patients by assessing the incidence of eligibility for each trial. DESIGN: Prospective, observational cohort study. We identified the 15 most highly cited randomized controlled trials in critical care medicine published between 1998 and 2008. We examined the inclusion and exclusion criteria for each randomized controlled trial and then assessed the eligibility of each patient admitted to a study ICU for each randomized controlled trial and calculated rates of potential trial eligibility in the cohort...
October 24, 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27742808/how-robust-are-clinical-trials-in-heart-failure
#10
Kieran F Docherty, Ross T Campbell, Pardeep S Jhund, Mark C Petrie, John J V McMurray
AIMS: Guidelines for the management of chronic heart failure (CHF) cite the results of randomized controlled trials (RCTs) to support treatment recommendations. The significance of an observed treatment-effect relies on the use of a boundary P-value, most commonly P < 0.05. There is concern about relying on arbitrary threshold P-values to report results as 'statistically significant'. The 'fragility index' (FI) has been proposed as an additional measure of the robustness of trial findings...
October 14, 2016: European Heart Journal
https://www.readbyqxmd.com/read/27697753/recommendations-to-improve-adverse-event-reporting-in-clinical-trial-publications-a-joint-pharmaceutical-industry-journal-editor-perspective
#11
Neil Lineberry, Jesse A Berlin, Bernadette Mansi, Susan Glasser, Michael Berkwits, Christian Klem, Ananya Bhattacharya, Leslie Citrome, Robert Enck, John Fletcher, Daniel Haller, Tai-Tsang Chen, Christine Laine
No abstract text is available yet for this article.
October 3, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27662077/the-value-of-p
#12
EDITORIAL
Sue Pondrom
No abstract text is available yet for this article.
October 2016: American Journal of Transplantation
https://www.readbyqxmd.com/read/27682033/predicting-the-future-big-data-machine-learning-and-clinical-medicine
#13
Ziad Obermeyer, Ezekiel J Emanuel
By now, it’s almost old news: big data will transform medicine. It’s essential to remember, however, that data by themselves are useless. To be useful, data must be analyzed, interpreted, and acted on. Thus, it is algorithms — not data sets — that will prove transformative. We believe, therefore,..
September 29, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27654606/pragmatic-trials-practical-answers-to-real-world-questions
#14
Harold C Sox, Roger J Lewis
No abstract text is available yet for this article.
September 20, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27653563/data-sharing-at-a-crossroads
#15
Frank Rockhold, Perry Nisen, Andrew Freeman
Sharing patient-level data from clinical trials can improve the quality of research and our understanding of disease and medical treatments. Various concerns have been voiced about data sharing; they involve privacy, consent, intellectual property, costs, infrastructure, data standards, free-riding..
September 22, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27654340/grade-methods-for-guideline-development-time-to-evolve
#16
Susan L Norris, Lisa Bero
No abstract text is available yet for this article.
December 6, 2016: Annals of Internal Medicine
https://www.readbyqxmd.com/read/27636028/toward-a-new-era-of-trust-and-transparency-in-clinical-trials
#17
Kathy L Hudson, Michael S Lauer, Francis S Collins
No abstract text is available yet for this article.
October 4, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27635471/trial-reporting-in-clinicaltrials-gov-the-final-rule
#18
Deborah A Zarin, Tony Tse, Rebecca J Williams, Sarah Carr
Title VIII of the Food and Drug Administration (FDA) Amendments Act of 2007 (FDAAA) expanded the legal mandate for sponsors and others responsible for certain clinical trials of FDA-regulated drug, biologic, and device products to register their studies and report summary results information to..
September 16, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27628074/clinical-trial-design-based-on-time-to-death-progression
#19
Susan Murray, Kevin R Flaherty
No abstract text is available yet for this article.
September 15, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27626515/clinical-trials-healthy-controls-and-the-birth-of-the-irb
#20
Laura Stark, Jeremy A Greene
No abstract text is available yet for this article.
September 15, 2016: New England Journal of Medicine
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