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21 papers 25 to 100 followers
https://www.readbyqxmd.com/read/27099136/evidence-based-clinical-practice-guidelines-for-nephrotic-syndrome-2014
#1
REVIEW
Shinichi Nishi, Yoshifumi Ubara, Yasunori Utsunomiya, Koichi Okada, Yoko Obata, Hiroyasu Kai, Hideyasu Kiyomoto, Shin Goto, Tsuneo Konta, Yoshie Sasatomi, Yoshinobu Sato, Tomoya Nishino, Kazuhiko Tsuruya, Kengo Furuichi, Junichi Hoshino, Yasuhiro Watanabe, Kenjiro Kimura, Seiichi Matsuo
No abstract text is available yet for this article.
June 2016: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/27151132/acg-clinical-guideline-management-of-patients-with-acute-lower-gastrointestinal-bleeding
#2
Lisa L Strate, Ian M Gralnek
No abstract text is available yet for this article.
May 2016: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/25216224/glucagon-like-peptide-1-receptor-expression-in-normal-and-diseased-human-thyroid-and-pancreas
#3
Beatrice Waser, Annika Blank, Eva Karamitopoulou, Aurel Perren, Jean C Reubi
Glucagon-like-peptide-1 (GLP1) analogs may induce thyroid or pancreatic diseases in animals, raising questions about their use in diabetic patients. There is, however, controversy regarding expression of GLP1 receptors (GLP1R) in human normal and diseased thyroid and pancreas. Here, 221 human thyroid and pancreas samples were analyzed for GLP1R immunohistochemistry and compared with quantitative in vitro GLP1R autoradiography. Neither normal nor hyperplastic human thyroids containing parafollicular C cells express GLP1R with either method...
March 2015: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/24424288/hope-and-fear-for-new-classes-of-type-2-diabetes-drugs-is-there-preclinical-evidence-that-incretin-based-therapies-alter-pancreatic-morphology
#4
REVIEW
Benjamin J Lamont, Sofianos Andrikopoulos
Incretin-based therapies appear to offer many advantages over other approaches for treating type 2 diabetes. Some preclinical studies have suggested that chronic activation of glucagon-like peptide 1 receptor (GLP1R) signalling in the pancreas may result in the proliferation of islet β-cells and an increase in β-cell mass. This provided hope that enhancing GLP1 action could potentially alter the natural progression of type 2 diabetes. However, to date, there has been no evidence from clinical trials suggesting that GLP1R agonists or dipeptidyl peptidase-4 (DPP4) inhibitors can increase β-cell mass...
April 2014: Journal of Endocrinology
https://www.readbyqxmd.com/read/26132124/management-of-blood-glucose-with-noninsulin-therapies-in-type-2-diabetes
#5
Christa M George, Lucy L Brujin, Kayley Will, Amanda Howard-Thompson
A comprehensive, collaborative approach is necessary for optimal treatment of patients with type 2 diabetes mellitus. Treatment guidelines focus on nutrition, exercise, and pharmacologic therapies to prevent and manage complications. Patients with prediabetes or new-onset diabetes should receive individualized medical nutrition therapy, preferably from a registered dietitian, as needed to achieve treatment goals. Patients should be treated initially with metformin because it is the only medication shown in randomized controlled trials to reduce mortality and complications...
July 1, 2015: American Family Physician
https://www.readbyqxmd.com/read/26880451/treatment-of-hyperkalemia-something-old-something-new
#6
REVIEW
Richard H Sterns, Marvin Grieff, Paul L Bernstein
Treatment options for hyperkalemia have not changed much since the introduction of the cation exchange resin, sodium polystyrene sulfonate (Kayexalate, Covis Pharmaceuticals, Cary, NC), over 50 years ago. Although clinicians of that era did not have ready access to hemodialysis or loop diuretics, the other tools that we use today-calcium, insulin, and bicarbonate-were well known to them. Currently recommended insulin regimens provide too little insulin to achieve blood levels with a maximal kalemic effect and too little glucose to avoid hypoglycemia...
March 2016: Kidney International
https://www.readbyqxmd.com/read/24912292/-treatment-of-status-epilepticus
#7
REVIEW
Hideo Yamanouchi
Status epilepticus is defined as epileptic seizure with the duration for over 30 min or clustered seizure without complete recovery of consciousness for 30 min or more. From the management point of view, therapeutic intervention is recommended for prolonged seizures for 5 min or more. Intranasal, buccal or intramuscular administration of midazolam is strongly evidence-based and highly recommended method for the treatment of prolonged seizures before the intravenous access. Diazepam or midazolam is the first choice as initial intravenous treatment...
May 2014: Nihon Rinsho. Japanese Journal of Clinical Medicine
https://www.readbyqxmd.com/read/25961083/vasopressor-and-inotrope-use-in-canadian-emergency-departments-evidence-based-consensus-guidelines
#8
EDITORIAL
Dennis Djogovic, Shavaun MacDonald, Andrea Wensel, Rob Green, Osama Loubani, Patrick Archambault, Simon Bordeleau, David Messenger, Adam Szulewski, Jon Davidow, Janeva Kircher, Sara Gray, Katherine Smith, James Lee, Jean Marc Benoit, Dan Howes
No abstract text is available yet for this article.
January 2015: CJEM
https://www.readbyqxmd.com/read/25943719/the-urine-sediment-as-a-biomarker-of-kidney-disease
#9
Mark A Perazella
The modern era of medicine has ushered in new diagnostic technologies to assist the clinician in evaluating patients with kidney disease. The birth of automated urine analysis technology and centralized laboratory testing has unfortunately made examination of urine sediment by physicians a rare event. At the same time, identifying novel urine biomarkers for kidney disease has become a research priority in nephrology, and the search for the "renal troponin" has progressed at a fast pace. Despite this, urine sediment examination remains a time-honored test that provides a wealth of information about the patient's kidney condition and performs favorably as a urinary biomarker...
November 2015: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/25776532/trial-of-early-goal-directed-resuscitation-for-septic-shock
#10
RANDOMIZED CONTROLLED TRIAL
Paul R Mouncey, Tiffany M Osborn, G Sarah Power, David A Harrison, M Zia Sadique, Richard D Grieve, Rahi Jahan, Sheila E Harvey, Derek Bell, Julian F Bion, Timothy J Coats, Mervyn Singer, J Duncan Young, Kathryn M Rowan
BACKGROUND: Early, goal-directed therapy (EGDT) is recommended in international guidelines for the resuscitation of patients presenting with early septic shock. However, adoption has been limited, and uncertainty about its effectiveness remains. METHODS: We conducted a pragmatic randomized trial with an integrated cost-effectiveness analysis in 56 hospitals in England. Patients were randomly assigned to receive either EGDT (a 6-hour resuscitation protocol) or usual care...
April 2, 2015: New England Journal of Medicine
https://www.readbyqxmd.com/read/25639461/molecular-mechanisms-of-helicobacter-pylori-pathogenesis
#11
REVIEW
Maria De Falco, Angela Lucariello, Salvatore Iaquinto, Vincenzo Esposito, Germano Guerra, Antonio De Luca
Helicobacter pylori infects 50% of mankind. The vast majority of H. pylori infection occurs in the developing countries where up to 80% of the middle-aged adults may be infected. Bacterial infection causes an inflammatory response that proceeds through a series of intermediated stages of precancerous lesions (gastritis, atrophy, intestinal metaplasia, and dysplasia). Among infected individuals, approximately 10% develops severe gastric lesions such as peptic ulcer disease, 1-3% progresses to gastric cancer (GC) with a low 5-year survival rate, and 0...
August 2015: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/25377394/opioid-analgesia-for-acute-abdominal-pain-in-children-a-systematic-review-and-meta-analysis
#12
REVIEW
Naveen Poonai, David Paskar, Shauna-Lee Konrad, Michael Rieder, Gary Joubert, Rodrick Lim, Asieh Golozar, Sefu Uledi, Andrew Worster, Samina Ali
OBJECTIVES: There are long-held concerns that analgesia in patients with acute abdominal pain may obscure the physical examination and lead to missing a diagnosis of appendicitis. Despite evidence to the contrary, analgesia continues to be underutilized and suboptimally dosed in children with acute abdominal pain. The objective of this systematic review and meta-analysis was to determine if opioids provide analgesia without an increase in side effects and appendicitis-related complications...
November 2014: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/24589670/the-problem-of-helicobacter-pylori-resistance-to-antibiotics-a-systematic-review-in-latin-america
#13
REVIEW
M Constanza Camargo, Apolinaria García, Arnoldo Riquelme, William Otero, Claudia A Camargo, Tomas Hernandez-García, Roberto Candia, Michael G Bruce, Charles S Rabkin
OBJECTIVES: Latin America has a high prevalence of Helicobacter pylori infection and associated diseases, including gastric cancer. Antibiotic therapy can eradicate the bacterial infection and decrease associated morbidity and mortality. To tailor recommendations for optimal treatments, we summarized published literature and calculated region- and country-specific prevalences of antibiotic resistance. METHODS: Searches of PubMed and regional databases for observational studies evaluating H...
April 2014: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/24355772/acute-abdominal-pain-due-to-spontaneous-rupture-of-the-right-gastric-artery
#14
Seungwoon Choi, Seokyong Ryu, Taekyung Kang, Hyejin Kim, Sungchan Oh, Sukjin Cho
Abdominal apoplexy was reported by Barber in 1909, and the occurrence rate of the apoplexy is known to be quite rare, but the mortality is high if untreated. We report an unusual case of abdominal apoplexy due to spontaneous rupture of gastric artery. A male patient in his fifth decade with recently diagnosed liver cirrhosis history arrived to the emergency department with severe abdominal pain, which led to abdominal computer tomography indicating spontaneous rupture of gastric artery. Celiac angiogram and embolization were conducted, and exploratory laparotomy was followed...
May 2014: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/24345888/clinical-effects-of-helicobacter-pylori-outside-the-stomach
#15
REVIEW
Francesco Franceschi, Giuseppe Zuccalà, Davide Roccarina, Antonio Gasbarrini
The discovery of Helicobacter pylori infection in the stomach could be considered as one of the most important events of modern gastroenterology. Understanding of the natural history of many disorders of the upper gastrointestinal tract, including chronic gastritis, peptic ulcer disease, gastric cancer and MALT lymphoma, was altered by this discovery. Interestingly, epidemiological studies have also revealed a correlation between H. pylori infection and some diseases localized outside the stomach, especially those characterized by persistent and low-grade systemic inflammation...
April 2014: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/23984731/severe-sepsis-and-septic-shock
#16
REVIEW
Derek C Angus, Tom van der Poll
New England Journal of Medicine, Volume 369, Issue 9, Page 840-851, August 2013.
August 29, 2013: New England Journal of Medicine
https://www.readbyqxmd.com/read/23981572/helicobacter-pylori-induced-gastric-inflammation-and-gastric-cancer
#17
REVIEW
Fei Wang, Wenbo Meng, Bingyuan Wang, Liang Qiao
Helicobacter pylori (H. pylori) infect over half of the world's population. The prevalence of H. pylori infection and the predominant genotype of H. pylori virulence factors vary considerably across different geographical regions. H. pylori could uniquely persist for decades in the harsh stomach environment, where it damages the gastric mucosa and changes the pattern of gastric hormone release, thereby affects gastric physiology. By utilizing various virulence factors, H. pylori targets different cellular proteins to modulate the host inflammatory response and initiate multiple "hits" on the gastric mucosa, resulting in chronic gastritis and peptic ulceration...
April 10, 2014: Cancer Letters
https://www.readbyqxmd.com/read/23490289/coronary-hypersensitivity-disorder-the-kounis-syndrome
#18
REVIEW
Nicholas G Kounis
BACKGROUND: When allergy or hypersensitivity and anaphylactic or anaphylactoid insults lead to cardiovascular symptoms and signs, including acute coronary events, the result might be the recently defined nosologic entity Kounis syndrome. Vasospastic allergic angina, allergic myocardial infarction, and stent thrombosis with occluding thrombus infiltrated by eosinophils and/or mast cells are the 3 reported variants of this syndrome. OBJECTIVE: The purpose of this review was to highlight and consolidate the recent literature on allergic angina and allergic myocardial infarction and to propose new therapeutic modalities for stabilizing mast cells...
May 2013: Clinical Therapeutics
https://www.readbyqxmd.com/read/23456166/thyroid-cancer-in-plummer-s-disease
#19
Queenie Guinto Ngalob, Iris Thiele Isip-Tan
Thyroid cancer with concomitant hyperthyroidism is rare. Most foci of malignancy are small and seen postoperatively as incidental findings after surgery for hyperthyroidism. Thyroid masses with clinical features of malignancy and concomitant hyperthyroidism are less-commonly reported. We report two cases of multinodular toxic goitre or Plummer's disease with clinical features of malignancy. Both patients had large multinodular goitres with evidence of metastasis to the manubrium for the first patient and to the lymph node and lungs for the second patient...
2013: BMJ Case Reports
https://www.readbyqxmd.com/read/22287700/medical-management-of-hepatorenal-syndrome
#20
REVIEW
Andrew Davenport, Jawad Ahmad, Ali Al-Khafaji, John A Kellum, Yuri S Genyk, Mitra K Nadim
Hepatorenal syndrome (HRS) is defined as the occurrence of renal dysfunction in a patient with end-stage liver cirrhosis in the absence of another identifiable cause of renal failure. The prognosis of HRS remains poor, with a median survival without liver transplantation of <6 months. However, understanding the pathogenesis of HRS has led to the introduction of treatments designed to increase renal perfusion and mean arterial blood pressure using vasopressors and albumin, which has led to improvement in renal function in ∼50% of patients...
January 2012: Nephrology, Dialysis, Transplantation
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