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Beavioral health

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35 papers 500 to 1000 followers
By Christopher Cook, BA,CADC, SAP Addiction professional. LPC, CADC, CRNP- student, Interventionist, project manager, owner, Director, eval/refer for SUDs/Eating D/o's
https://www.readbyqxmd.com/read/28751130/in-vivo-gamma-aminobutyric-acid-and-glutamate-levels-in-people-with-first-episode-schizophrenia-a-proton-magnetic-resonance-spectroscopy-study
#1
P W Chiu, Simon S Y Lui, Karen S Y Hung, Raymond C K Chan, Queenie Chan, P C Sham, Eric F C Cheung, Henry K F Mak
BACKGROUND: Gamma-aminobutyric acid (GABA) dysfunction and its consequent imbalance are implicated in the pathophysiology of schizophrenia. Reduced GABA production would lead to a disinhibition of glutamatergic neurons and subsequently cause a disruption of the modulation between GABAergic interneurons and glutamatergic neurons. In this study, levels of GABA, Glx (summation of glutamate and glutamine), and other metabolites in the anterior cingulate cortex were measured and compared between first-episode schizophrenia subjects and healthy controls (HC)...
March 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29690791/anxiety-about-antidepressants
#2
Roy H Perlis
No abstract text is available yet for this article.
April 25, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29734827/behavioral-addictions-as-mental-disorders-to-be-or-not-to-be
#3
Nancy M Petry, Kristyn Zajac, Meredith K Ginley
Should excessive and problematic engagement in nonsubstance use behaviors be mental disorders? The fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) repositioned gambling disorder in the substance use disorders section and introduced Internet gaming disorder in the research appendix; the International Classification of Diseases (ICD-11) is also considering it. This article outlines pros and cons of considering behavioral addictions as mental disorders and also reviews the DSM-5 decision-making processes...
May 7, 2018: Annual Review of Clinical Psychology
https://www.readbyqxmd.com/read/28946762/cannabis-use-and-risk-of-prescription-opioid-use-disorder-in-the-united-states
#4
Mark Olfson, Melanie M Wall, Shang-Min Liu, Carlos Blanco
OBJECTIVE: The authors sought to determine whether cannabis use is associated with a change in the risk of incident nonmedical prescription opioid use and opioid use disorder at 3-year follow-up. METHOD: The authors used logistic regression models to assess prospective associations between cannabis use at wave 1 (2001-2002) and nonmedical prescription opioid use and prescription opioid use disorder at wave 2 (2004-2005) of the National Epidemiologic Survey on Alcohol and Related Conditions...
January 1, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29257977/the-impact-of-psychosis-genome-wide-associated-znf804a-variation-on-verbal-fluency-connectivity
#5
Diogo Tecelão, Ana Mendes, Daniel Martins, Elvira Bramon, Timothea Toulopoulou, Eugenia Kravariti, Robin Murray, Diana Prata
Schizophrenia (SCZ) and bipolar disorder (BD) have high heritability. Genome-wide association studies (GWAS) have identified ZNF804A as a significant risk gene for both illnesses. A validation of this finding at the brain systems-level is imperative as there is still little understanding of how it heightens risk. Based in part on our recent findings of an effect on widespread decreased white matter microstructural fractional anisotropy (putatively a proxy of its integrity), particularly strong in SCZ, we asked whether the risk allele has a detrimental effect on regional brain activation and functional connectivity during a type of cognitive processing which is, together with its neural correlates, impaired in BD and SCZ: verbal fluency...
March 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29543333/a-marxist-therapist-treats-a-trump-supporting-client-a-tale-of-politics-and-psychotherapy
#6
David B Yourman
When there are politically polarizing events taking place in the world, can it be useful for a therapist to disclose his or her political views within the context of a psychotherapeutic dyad? This paper examines this question through the example of a Marxist therapist working with a politically conservative patient in the polarized political atmosphere following Donald Trump's election to the Presidency of the United States. Also explored are the patient's dynamics that might have made it particularly salient for the therapist to eschew a more neutral stance...
May 2018: Journal of Clinical Psychology
https://www.readbyqxmd.com/read/29021832/pharmacogenomics-in-the-treatment-of-mood-disorders-strategies-and-opportunities-for-personalized-psychiatry
#7
REVIEW
Azmeraw T Amare, Klaus Oliver Schubert, Bernhard T Baune
Personalized medicine (personalized psychiatry in a specific setting) is a new model towards individualized care, in which knowledge from genomics and other omic pillars (microbiome, epigenomes, proteome, and metabolome) will be combined with clinical data to guide efforts to new drug development and targeted prescription of the existing treatment options. In this review, we summarize pharmacogenomic studies in mood disorders that may lay the foundation towards personalized psychiatry. In addition, we have discussed the possible strategies to integrate data from omic pillars as a future path to personalized psychiatry...
September 2017: EPMA Journal
https://www.readbyqxmd.com/read/28864753/bipolar-disorder-and-addictions-the-elephant-in-the-room
#8
EDITORIAL
Paul R A Stokes, Nicola J Kalk, Allan H Young
Addictions are highly prevalent in bipolar disorder and greatly affect clinical outcomes. In this editorial, we review the evidence that addictions are a key challenge in bipolar disorder, examine putative neurobiological mechanisms, and reflect on the limited clinical trial evidence base with suggestions for treatment strategies and further developments.
September 2017: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/28838328/backing-into-the-future-pharmacological-approaches-to-the-management-of-resistant-depression
#9
P J Cowen
Pragmatic studies indicate that a substantial number of depressed patients do not remit with current first-line antidepressant treatments and after two failed treatment steps the chance of remission with subsequent therapies is around 15%. This paper focuses on current evidence for pharmacological treatments in resistant depression as well as possible future developments. For patients who have failed to respond to two antidepressant trials, augmentation with atypical antipsychotic drugs, specifically quetiapine and aripiprazole, has the best evidence for efficacy, though older treatments such as lithium and triiodothyronine still have utility...
November 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28439098/uncoupling-dapk1-from-nmda-receptor-glun2b-subunit-exerts-rapid-antidepressant-like-effects
#10
S-X Li, Y Han, L-Z Xu, K Yuan, R-X Zhang, C-Y Sun, D-F Xu, M Yuan, J-H Deng, S-Q Meng, X-J Gao, Q Wen, L-J Liu, W-L Zhu, Y-X Xue, M Zhao, J Shi, L Lu
Several preclinical studies have reported the rapid antidepressant effects of N-methyl-D-aspartate receptor (NMDAR) antagonists, although the underlying mechanisms are still unclear. Death-associated protein kinase 1 (DAPK1) couples GluN2B subunits at extrasynaptic sites to regulate NMDAR channel conductance. In the present study, we found that chronic unpredictable stress (CUS) induced extracellular glutamate accumulation, accompanied by an increase in the DAPK1-NMDAR interaction, the high expression of DAPK1 and phosphorylated GluN2B at Ser1303, a decrease in phosphorylated DAPK1 at Ser308 and synaptic protein deficits in the rat medial prefrontal cortex (mPFC)...
March 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/28406363/insurance-receipt-and-readiness-for-opportunities-under-the-affordable-care-act-a-national-survey-of-treatment-providers-for-substance-use-disorders
#11
Lydia Aletraris, Mary Bond Edmond, Paul M Roman
This study measures the readiness of substance use disorder (SUD) treatment to use opportunities under the Affordable Care Act by examining Medicaid and private insurance acceptance between 2011 and 2013, as well as center characteristics associated with acceptance. Data for this study were from a random sample of SUD treatment centers in the United States. Interviews were conducted on site and face to face, with administrative and clinical directors. We employed logistic regression analyses to examine Medicaid acceptance and private insurance acceptance...
April 2017: Journal of Psychoactive Drugs
https://www.readbyqxmd.com/read/28481178/psilocybin-assisted-therapy-a-review-of-a-novel-treatment-for-psychiatric-disorders
#12
Kelan Thomas, Benjamin Malcolm, Dan Lastra
Recent research suggests that functional connectivity changes may be involved in the pathophysiology of psychiatric disorders. Hyperconnectivity in the default mode network has been associated with psychopathology, but psychedelic serotonin agonists like psilocybin may profoundly disrupt these dysfunctional neural network circuits and provide a novel treatment for psychiatric disorders. We have reviewed the current literature to investigate the efficacy and safety of psilocybin-assisted therapy for the treatment of psychiatric disorders...
November 2017: Journal of Psychoactive Drugs
https://www.readbyqxmd.com/read/28293623/patients-experience-of-winter-depression-and-light-room-treatment
#13
Cecilia Rastad, Lennart Wetterberg, Cathrin Martin
Background . There is a need for more knowledge on the effects of light room treatment in patients with seasonal affective disorder and to explore patients' subjective experience of the disease and the treatment. Methods . This was a descriptive and explorative study applying qualitative content analysis. A purposeful sample of 18 psychiatric outpatients with a major depressive disorder with a seasonal pattern and a pretreatment score ≥12 on the 9-item Montgomery-Åsberg Depression self-rating scale was included (10 women and 8 men, aged 24-65 years)...
2017: Psychiatry Journal
https://www.readbyqxmd.com/read/27630999/common-mental-disorders-among-occupational-groups-contributions-of-the-latent-class-model
#14
Kionna Oliveira Bernardes Santos, Fernando Martins Carvalho, Tânia Maria de Araújo
Background. The Self-Reporting Questionnaire (SRQ-20) is widely used for evaluating common mental disorders. However, few studies have evaluated the SRQ-20 measurements performance in occupational groups. This study aimed to describe manifestation patterns of common mental disorders symptoms among workers populations, by using latent class analysis. Methods. Data derived from 9,959 Brazilian workers, obtained from four cross-sectional studies that used similar methodology, among groups of informal workers, teachers, healthcare workers, and urban workers...
2016: Psychiatry Journal
https://www.readbyqxmd.com/read/21893093/the-pharmacological-importance-of-agmatine-in-the-brain
#15
REVIEW
Tayfun I Uzbay
Agmatine is a polyamine that is produced via decarboxylation of l-arginine by the enzyme arginine decarboxylase. It binds to various receptors and has been accepted as a novel neurotransmitter in brain. In experimental studies, agmatine exhibited anticonvulsant, antinociceptive, anxiolytic and antidepressant-like actions. Furthermore, it has some beneficial effects on cerebral ischemia models in animals. Agmatine interacts with the mechanisms of withdrawal syndromes for several addictive agents. It also modulates some processes involved in learning and memory...
January 2012: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28748784/testosterone-and-aggression-more-than-just-biology
#16
Emil F Coccaro
No abstract text is available yet for this article.
August 15, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28748788/reward-mechanisms-across-aggressive-and-addictive-forms-of-externalizing-psychopathology
#17
COMMENT
Noah C Venables
No abstract text is available yet for this article.
August 15, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28760026/amygdala-guided-neurofeedback-for-major-depression
#18
EDITORIAL
Leanne M Williams
No abstract text is available yet for this article.
August 1, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28293192/indole-alkaloids-from-plants-as-potential-leads-for-antidepressant-drugs-a-mini-review
#19
Hazrulrizawati A Hamid, Aizi N M Ramli, Mashitah M Yusoff
Depression is the most common illness observed in the elderly, adults, and children. Antidepressants prescribed are usually synthetic drugs and these can sometimes cause a wide range of unpleasant side effects. Current research is focussed on natural products from plants as they are a rich source of potent new drug leads. Besides Hypericum perforatum (St. John's wort), the plants studied include Passiflora incarnata L. (passion flower), Mitragyna speciosa (kratom), Piper methysticum G. Forst (kava) and Valeriana officinalis L...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28388917/influence-of-diet-on-the-gut-microbiome-and-implications-for-human-health
#20
REVIEW
Rasnik K Singh, Hsin-Wen Chang, Di Yan, Kristina M Lee, Derya Ucmak, Kirsten Wong, Michael Abrouk, Benjamin Farahnik, Mio Nakamura, Tian Hao Zhu, Tina Bhutani, Wilson Liao
Recent studies have suggested that the intestinal microbiome plays an important role in modulating risk of several chronic diseases, including inflammatory bowel disease, obesity, type 2 diabetes, cardiovascular disease, and cancer. At the same time, it is now understood that diet plays a significant role in shaping the microbiome, with experiments showing that dietary alterations can induce large, temporary microbial shifts within 24 h. Given this association, there may be significant therapeutic utility in altering microbial composition through diet...
April 8, 2017: Journal of Translational Medicine
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