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By Javier Romero Yo
Marcus Harbord, Vito Annese, Stephan R Vavricka, Matthieu Allez, Manuel Barreiro-de Acosta, Kirsten Muri Boberg, Johan Burisch, Martine De Vos, Anne-Marie De Vries, Andrew D Dick, Pascal Juillerat, Tom H Karlsen, Ioannis Koutroubakis, Peter L Lakatos, Tim Orchard, Pavol Papay, Tim Raine, Max Reinshagen, Diamant Thaci, Herbert Tilg, Franck Carbonnel
No abstract text is available yet for this article.
March 2016: Journal of Crohn's & Colitis
Adam S Cheifetz
IMPORTANCE: Treatment of Crohn disease is rapidly evolving, with the induction of novel biologic therapies and newer, often more intensive treatment approaches. Knowing how to treat individual patients in this quickly changing milieu can be a challenge. OBJECTIVE: To review the diagnosis and management of moderate to severe Crohn disease, with a focus on newer treatments and goals of care. EVIDENCE REVIEW: MEDLINE was searched from 2000 to 2011...
May 22, 2013: JAMA: the Journal of the American Medical Association
Akane Mukai, Shuji Yamamoto, Kazuyoshi Matsumura
A 42-year-old female with Crohn's disease who had previously undergone multiple surgical interventions developed marked hypocalcemia, which could not be resolved with calcium administration. Markedly reduced serum magnesium levels were also observed. After intravenous magnesium administration, serum calcium levels rapidly normalized. In addition, the plasma levels of intact parathyroid hormone increased immediately after magnesium administration. These data strongly suggest that hypocalcemia resulted from disturbance of appropriate parathyroid hormone secretion caused by hypomagnesemia...
February 2015: Clinical Journal of Gastroenterology
Ad A van Bodegraven, Nathalie Bravenboer, Birgit I Witte, Gerard Dijkstra, C Janneke van der Woude, Pieter C M Stokkers, Maurice G Russel, Bas Oldenburg, Marieke Pierik, Jan C Roos, Ruud A van Hogezand, Vincent K Dik, Angela E Oostlander, J Coen Netelenbos, Lex van de Langerijt, Daniel W Hommes, Paul Lips
OBJECTIVE: Osteoporosis and fractures are frequently encountered in patients with Crohn's disease. In order to prevent fractures, treatment with bone protecting drugs appears warranted early in the course of bone disease when bone loss is not yet prominent. We therefore aimed to demonstrate a beneficial effect on bone density of the bisphosphonate risedronate in osteopenic Crohn's disease patients. METHODS: This double-blind, placebo-controlled randomised trial of risedronate with calcium and vitamin D supplementation was performed in osteopenic Crohn's disease patients...
September 2014: Gut
Daniel C Baumgart, William J Sandborn
Crohn's disease is a relapsing systemic inflammatory disease, mainly affecting the gastrointestinal tract with extraintestinal manifestations and associated immune disorders. Genome wide association studies identified susceptibility loci that--triggered by environmental factors--result in a disturbed innate (ie, disturbed intestinal barrier, Paneth cell dysfunction, endoplasmic reticulum stress, defective unfolded protein response and autophagy, impaired recognition of microbes by pattern recognition receptors, such as nucleotide binding domain and Toll like receptors on dendritic cells and macrophages) and adaptive (ie, imbalance of effector and regulatory T cells and cytokines, migration and retention of leukocytes) immune response towards a diminished diversity of commensal microbiota...
November 3, 2012: Lancet
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