Puja P Khanna, Heather S Gladue, Manjit K Singh, John D FitzGerald, Sangmee Bae, Shraddha Prakash, Marian Kaldas, Maneesh Gogia, Veronica Berrocal, Whitney Townsend, Robert Terkeltaub, Dinesh Khanna
OBJECTIVE: Acute gout is traditionally treated with NSAIDs, corticosteroids, and colchicine; however, subjects have multiple comorbidities that limit the use of some conventional therapies. We systematically reviewed the published data on the pharmacologic and non-pharmacologic agents used for the treatment of acute gouty arthritis. METHODS: A systematic search was performed using PubMed and Cochrane database through May 2013. We included only randomized controlled trials (RCTs) that included NSAIDs, corticosteroids, colchicine, adrenocorticotropic hormone (ACTH), interleukin-1 (IL-1) inhibitors, topical ice, or herbal supplements...
August 2014: Seminars in Arthritis and Rheumatism