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https://www.readbyqxmd.com/read/26416949/off-label-use-of-agents-for-management-of-serious-or-life-threatening-angiotensin-converting-enzyme-inhibitor-induced-angioedema
#1
REVIEW
Colleen M Culley, Julie N DiBridge, Gregory L Wilson
OBJECTIVE: To evaluate the place in therapy of fresh frozen plasma (FFP), C1 esterase concentrate (C1-INH), ecallantide, and icatibant in the management of angiotensin-converting enzyme inhibitor-induced angioedema (ACEI-IA). DATA SOURCES: A literature search was performed using PubMed (1946 through August 2015) and Embase (<1966 through August 2015). References from identified articles were reviewed. STUDY SELECTION AND DATA EXTRACTION: Consensus papers, practice guidelines, case reports/series, clinical trials, and meeting abstracts published in English and involving humans were included...
January 2016: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/26234714/anticoagulation-reversal-with-prothrombin-complex-concentrate-in-aneurysmal-subarachnoid-hemorrhage
#2
Christopher Beynon, Mohammed Nofal, Timolaos Rizos, Mona Laible, Anna Potzy, Andreas W Unterberg, Oliver W Sakowitz
BACKGROUND: Intracerebral hemorrhage is a well-recognized complication of anticoagulation therapy. However, there are only a few reports that address the management of aneurysmal subarachnoid hemorrhage (aSAH) in anticoagulated patients. OBJECTIVE: We report on our experiences with the use of prothrombin complex concentrate (PCC) for rapid anticoagulation reversal in aSAH. METHODS: We retrospectively analyzed our institutional database of consecutive patients who received PCC between February 2006 and August 2014 (n > 1000)...
November 2015: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/25830424/clinical-practice-emergency-contraception
#3
REVIEW
Elizabeth G Raymond, Kelly Cleland
New England Journal of Medicine, Volume 372, Issue 14, Page 1342-1348, April 2015.
April 2, 2015: New England Journal of Medicine
https://www.readbyqxmd.com/read/26233615/diagnostic-value-of-lead-avr-in-acute-coronary-syndrome
#4
LETTER
Soheila Talebi, Ferdinand Visco, Gerald Pekler, Mushiyev Savi, George Fernaine, Sameer Chaudhari, Getaw Worku Hassen
No abstract text is available yet for this article.
October 2015: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/26194607/a-preprocedural-checklist-improves-the-safety-of-emergency-department-intubation-of-trauma-patients
#5
Kurt A Smith, Kevin High, Sean P Collins, Wesley H Self
OBJECTIVES: Endotracheal intubation of trauma patients is a vital and high-risk procedure in the emergency department (ED). The hypothesis was that implementation of a standardized, preprocedural checklist would improve the safety of this procedure. METHODS: A preprocedural intubation checklist was developed and then implemented in a prospective pre-/postinterventional study in an academic trauma center ED. The proportions of trauma patients older than 16 years who experienced intubation-related complications during the 6 months before checklist implementation and 6 months after implementation were compared...
August 2015: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/26166378/comparison-of-oral-oxycodone-and-naproxen-in-soft-tissue-injury-pain-control-a-double-blind-randomized-clinical-trial
#6
RANDOMIZED CONTROLLED TRIAL
Marzieh Fathi, Mohammad Amin Zare, Hamid Reza Bahmani, Shahriar Zehtabchi
OBJECTIVES: This randomized clinical trial compares the efficacy and safety of oral oxycodone (an oral opioid) with naproxen (a nonsteroidal anti-inflammatory drug) in acute pain control in patients with soft tissue injury. It also evaluates the need for additional doses of analgesics in the first 24 hours of discharge from emergency department (ED). METHODS: Adult (>18 years old) patients with soft tissue injuries were enrolled in a teaching urban ED. Subjects were randomly allocated to receive a single dose of oral oxycodone (5 mg) or oral naproxen (250 mg)...
September 2015: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/26152915/a-centrally-acting-antihypertensive-clonidine-combined-to-a-venous-dilator-nitroglycerin-to-handle-severe-pulmonary-edema
#7
Philippe Schraub, M Vecchi, Marc Matthys, Bernard Lecomte, Nicolas Ferrara, Marco Ghignone, Luc Quintin
A patient, with known left ventricular failure presented with severe pulmonary edema, an ejection fraction of 10% to 15%, knee mottling, and lactates of 7 mM L⁻¹. He was treated with unusually high-dose nitroglycerin (NTG) intravenously (IV; NTG ≈ 70 mg for 1 hour). To suppress dyspnea, systolic blood pressure had to be lowered from ≈ 150-160 to ≈ 100-120 mm Hg. To lower NTG requirement, an α-2 agonist, clonidine, was administered (300 μg IV for 2 hours). Dyspnea, tachypnea, and tachycardia subsided for 1 to 2 hours, allowing to reduce NTG infusion to 2 to 4 mg h⁻¹...
March 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/26143315/evaluation-of-fixed-dose-4-factor-prothrombin-complex-concentrate-for-emergent-warfarin-reversal
#8
Lauren Klein, Jessica Peters, James Miner, Jed Gorlin
OBJECTIVES: Four-factor prothrombin complex concentrates (4FPCCs) are emerging as the standard of care for emergent warfarin reversal due to their ability to rapidly and effectively achieve hemostasis. The ideal dose of this medication is not known. Recently, our hospital instituted a protocol where all doses of 4FPCC were a fixed dose of 1500 IU. This protocol provides 4FPCC rapidly and precludes delay waiting for international normalized ratio (INR) values. The purpose of this study was to evaluate our experience with this fixed dose protocol...
September 2015: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/26143313/efficacy-and-safety-of-nebulized-morphine-given-at-2-different-doses-compared-to-iv-titrated-morphine-in-trauma-pain
#9
RANDOMIZED CONTROLLED TRIAL
Mohamed Habib Grissa, Hamdi Boubaker, Asma Zorgati, Kaouthar Beltaïef, Wafa Zhani, Mohamed Amine Msolli, Nasri Bzeouich, Wahid Bouida, Riadh Boukef, Semir Nouira
BACKGROUND: Our aim was to compare the efficacy and safety of intravenous (IV) titrated morphine with nebulized morphine given at 2 different doses in severe traumatic pain. METHODS: In a prospective, randomized, controlled double-blind study, we included 300 patients with severe traumatic pain. They were assigned to 3 groups: Neb10 group received 1 nebulization of 10-mg morphine; Neb20 group received 1 nebulization of 20-mg morphine, repeated every 10 minutes with a maximum of 3 nebulizations; and the IV morphine group received 2-mg IV morphine repeated every 5 minutes until pain relief...
November 2015: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/26130219/hot-off-the-press-subdissociative-dose-ketamine-for-acute-pain-in-the-emergency-department
#10
Aaran B Drake, William K Milne, Christopher R Carpenter
No abstract text is available yet for this article.
July 2015: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/26113020/the-diagnostic-performance-of-the-richmond-agitation-sedation-scale-for-detecting-delirium-in-older-emergency-department-patients
#11
Jin H Han, Eduard E Vasilevskis, John F Schnelle, Ayumi Shintani, Robert S Dittus, Amanda Wilson, E Wesley Ely
OBJECTIVES: Delirium is frequently missed in older emergency department (ED) patients. Brief (<2 minutes) delirium assessments have been validated for the ED, but some ED health care providers may consider them to be cumbersome. The Richmond Agitation Sedation Scale (RASS) is an observational scale that quantifies level of consciousness and takes less than 10 seconds to perform. The authors sought to explore the diagnostic accuracy of the RASS for delirium in older ED patients. METHODS: This was a preplanned analysis of a prospective observational study designed to validate brief delirium assessments for the ED...
July 2015: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/26088087/tranexamic-acid-for-epistaxis-a-promising-treatment-that-deserves-further-study
#12
COMMENT
David Clinkard, David Barbic
CLINICAL QUESTION: Does the application of topical tranexamic acid reduce bleeding as compared to anterior packing? ARTICLE CHOSEN: Zahed R, Moharamzadeh P, Alizadeharasi S, et al. A new and rapid method for epistaxis treatment using injectable form of tranexamic acid topically: a randomized controlled trial. Am J Emerg Med 2013;31(9):1389-92. OBJECTIVES: To determine if topically applied tranexamic acid reduces bleeding time in epistaxis...
January 2016: CJEM
https://www.readbyqxmd.com/read/26067924/vasopressor-and-inotrope-use-in-canadian-emergency-departments-evidence-based-consensus-guidelines
#13
REVIEW
Dennis Djogovic, Shavaun MacDonald, Andrea Wensel, Rob Green, Osama Loubani, Patrick Archambault, Simon Bordeleau, David Messenger, Adam Szulewski, Jon Davidow, Janeva Kircher, Sara Gray, Katherine Smith, James Lee, Jean Marc Benoit, Dan Howes
No abstract text is available yet for this article.
February 2015: CJEM
https://www.readbyqxmd.com/read/26027886/comparing-biomarkers-of-traumatic-shock-the-utility-of-anion-gap-base-excess-and-serum-lactate-in-the-ed
#14
Nicholas D Caputo, Marc Kanter, Robert Fraser, Ronald Simon
BACKGROUND: Biomarkers such as serum lactate, anion gap (AG), and base excess (BE) have been shown to be of use in determining shock in patients with seemingly normal vital signs. We seek to determine if these biomarkers can be used interchangeably in patients with trauma in the emergency setting based on their test characteristics and correlation to each other. METHODS: A prospective observational cohort study was undertaken at an urban level 1 trauma center. Baseline vital signs, point-of-care BE, AG, and serum lactate were recorded in all patients who presented for trauma...
September 2015: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/25921968/comparison-of-antiemetics-for-nausea-and-vomiting-of-pregnancy-in-an-emergency-department-setting
#15
COMPARATIVE STUDY
Elizabeth A Mayhall, Robyn Gray, Vrishali Lopes, Kristen A Matteson
OBJECTIVE: To compare time from medication administration to disposition from the Emergency Department (ED) between women treated for nausea and vomiting of pregnancy with different antiemetic agents. DESIGN: We performed a retrospective cohort study of women 13 weeks gestation or less treated in our Women and Infants Hospital ED for nausea and vomiting of pregnancy between 2009 and 2011. Data was collected on patient demographics, antiemetics used, and time to disposition...
July 2015: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/25910673/the-critical-care-literature-2014
#16
REVIEW
Michael E Winters, Joseph P Martinez, Haney Mallemat, William J Brady
No abstract text is available yet for this article.
June 2015: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/25873702/how-much-did-you-take-reviewing-acetaminophen-toxicity
#17
REVIEW
Jesse Janssen, Sanjeet Singh-Saluja
No abstract text is available yet for this article.
April 2015: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/25817884/intravenous-subdissociative-dose-ketamine-versus-morphine-for-analgesia-in-the-emergency-department-a-randomized-controlled-trial
#18
RANDOMIZED CONTROLLED TRIAL
Sergey Motov, Bradley Rockoff, Victor Cohen, Illya Pushkar, Antonios Likourezos, Courtney McKay, Emil Soleyman-Zomalan, Peter Homel, Victoria Terentiev, Christian Fromm
STUDY OBJECTIVE: We assess and compare the analgesic efficacy and safety of subdissociative intravenous-dose ketamine with morphine in emergency department (ED) patients. METHODS: This was a prospective, randomized, double-blind trial evaluating ED patients aged 18 to 55 years and experiencing moderate to severe acute abdominal, flank, or musculoskeletal pain, defined as a numeric rating scale score greater than or equal to 5. Patients were randomized to receive ketamine at 0...
September 2015: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/25749404/choosing-analgesics-wisely-what-we-know-and-still-need-to-know-about-long-term-consequences-of-opioids
#19
EDITORIAL
Jeanmarie Perrone, Lewis S Nelson, Donald M Yealy
No abstract text is available yet for this article.
May 2015: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/25724624/can-children-with-uncomplicated-acute-appendicitis-be-treated-with-antibiotics-instead-of-an-appendectomy
#20
REVIEW
Jennifer A Horst, Indi Trehan, Brad W Warner, Brian G Cohn
No abstract text is available yet for this article.
August 2015: Annals of Emergency Medicine
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