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By Rod VR
Yahiya Y Syed
AbobotulinumtoxinA (Dysport® ) is currently the only botulinum toxin A formulation approved by the US FDA for the treatment of lower limb spasticity in pediatric patients aged ≥2 years. Intramuscular abobotulinumtoxinA was approved based on the results of a pivotal phase 3 trial in children with lower limb spasticity due to cerebral palsy. In this trial, a single treatment cycle with abobotulinumtoxinA 10-15 U/kg/leg injected into the gastrocnemius and soleus muscles significantly improved ankle plantar flexor muscle tone (primary endpoint), with abobotulinumtoxinA recipients showing a significant response to treatment relative to placebo...
August 2017: Paediatric Drugs
Wannisa Kumban, Sugalya Amatachaya, Alongkot Emasithi, Wantana Siritaratiwat
OBJECTIVE: To examine the relationship between Five times sit-to-stand Test (FTSST) and functional tests and investigate the effects of task-specific training on functional ability in children with mild to moderate cerebral palsy (CP). METHODS: Twenty-one subjects were randomly assigned to experimental and control groups. Motor Assessment Scale (MAS: sit-to-stand), Pediatric Balance Scale (PBS), Functional Reach Test and FTSST were tested before training, after training and at follow-up at 6 weeks post training...
December 2013: Developmental Neurorehabilitation
Lisa C Drefus, Melanie A Buckland, Sherry I Backus, Leon Root
The purpose of this study was to determine the effect of a distal rectus femoris tenotomy on function and gait in adults with cerebral palsy who had diminished knee flexion during swing. A stiff knee gait pattern is commonly seen in individuals with cerebral palsy and frequently leads to tripping and falling. Five subjects, 25-51 years, (34.6±10.3 years) participated in the study; each individual had the surgery after the age of 18. Four of the five subjects underwent bilateral distal rectus femoris tenotomies for a total of nine limbs being studied...
2014: Gait & Posture
Terje Terjesen, Gro D Lie, Asne A Hyldmo, Andreas Knaus
BACKGROUND: There is a risk of hip dislocation in children with spastic cerebral palsy. We evaluated the prophylactic effect of adductor tenotomy in patients with long-term follow-up. PATIENTS AND METHODS: Our material comprised 78 patients (46 boys) with a mean age of 8 (2-17) years who underwent adductor tenotomy during the period 1986-1991. 40 patients had spastic diplegia and 38 had quadriplegia. For patients who had further hip surgery, follow-up was until the next hip operation...
February 2005: Acta Orthopaedica
Ettore Laracca, Caroline Stewart, Neil Postans, Andrew Roberts
Children with cerebral palsy often undergo multiple orthopaedic surgical procedures in a single episode. Evidence of the effectiveness of individual components within the overall package is sparse. The introduction of musculoskeletal modelling in Oswestry has led to a more conservative management approach being taken with hamstring muscles for children walking in a degree of crouch. Muscles which were shown to be of at least normal length at initial contact were not surgically lengthened, as would have been the case previously...
March 2014: Gait & Posture
Catherine Morgan, Johanna Darrah, Andrew M Gordon, Regina Harbourne, Alicia Spittle, Robert Johnson, Linda Fetters
AIM: To systematically review the evidence on the effectiveness of motor interventions for infants from birth to 2 years with a diagnosis of cerebral palsy or at high risk of it. METHOD: Relevant literature was identified by searching journal article databases (PubMed, Embase, CINAHL, Cochrane, Web of Knowledge, and PEDro). Selection criteria included infants between the ages of birth and 2 years diagnosed with, or at risk of, cerebral palsy who received early motor intervention...
September 2016: Developmental Medicine and Child Neurology
Elizabeth Herrera-Anaya, Adriana Angarita-Fonseca, Víctor M Herrera-Galindo, Rocío D P Martínez-Marín, Cindy N Rodríguez-Bayona
AIM: To determine the association between gross motor function and nutritional status in children with cerebral palsy (CP) residing in an urban area in a developing country. METHOD: We conducted a cross-sectional study in 177 children (ages 2-12y, 59.3% male) with a diagnosis of CP who were attending rehabilitation centres in Bucaramanga, Colombia (2012-2013). A physiotherapist evaluated patients using the Gross Motor Function Classification System (GMFCS, levels I to V)...
September 2016: Developmental Medicine and Child Neurology
Christa Einspieler, Robert Peharz, Peter B Marschik
OBJECTIVES: To describe fidgety movements (FMs), i.e., the spontaneous movement pattern that typically occurs at 3-5 months after term age, and discuss its clinical relevance. SOURCES: A comprehensive literature search was performed using the following databases: MEDLINE/PubMed, CINAHL, The Cochrane Library, Science Direct, PsycINFO, and EMBASE. The search strategy included the MeSH terms and search strings ('fidgety movement*') OR [('general movement*') AND ('three month*') OR ('3 month*')], as well as studies published on the General Movements Trust website (www...
May 2016: Jornal de Pediatria
Paz Kedem, David M Scher
PURPOSE OF REVIEW: Crouch gait is defined as excessive ankle dorsiflexion, knee and hip flexion during the stance phase. This gait disorder is common among patients with cerebral palsy. The present article brings an up-to-date literature review on the pathoanatomy, natural history, and treatment of this frequent gait abnormality. RECENT FINDINGS: Hamstrings are often not shortened in patients with crouch. Patella alta must be addressed if surgery is performed. Surgical correction of joint contractures and lever arm dysfunction can be effectively achieved through a single-event multilevel surgery...
February 2016: Current Opinion in Pediatrics
Joseph J Ruzbarsky, David Scher, Emily Dodwell
PURPOSE OF REVIEW: The present review includes the most up-to-date literature on the causes, epidemiology, diagnosis, and treatment of toe walking. RECENT FINDINGS: The prevalence of toe walking at age 5.5 years is 2% in normally developing children, and 41% in children with a neuropsychiatric diagnosis or developmental delays. A recent systematic review concluded that there is good evidence for casting and surgery in the treatment of idiopathic toe walking, with only surgery providing long-term results beyond 1 year...
February 2016: Current Opinion in Pediatrics
Izabela Blaszczyk, Nazli Poorsafar Foumani, Christina Ljungberg, Mikael Wiberg
Botulinum toxin A (BoNT-A) injections for treatment of spasticity in patients with cerebral palsy (CP) have been used for about two decades. The treatment is considered safe but a low frequency of adverse events (AE) has been reported. A good method to report AEs is necessary to verify the safety of the treatment. We decided to use an active surveillance of treatment-induced harm using a questionnaire we created. We studied the incidence of reported AEs and side effects in patients with CP treated with BoNT-A...
November 6, 2015: Toxins
Francesca Penagini, Chiara Mameli, Valentina Fabiano, Domenica Brunetti, Dario Dilillo, Gian Vincenzo Zuccotti
Neurologically impaired (NI) children are at increased risk of malnutrition due to several nutritional and non-nutritional factors. Among the nutritional factors, insufficient dietary intake as a consequence of feeding difficulties is one of the main issues. Feeding problems are frequently secondary to oropharyngeal dysphagia, which usually correlates with the severity of motor impairment and presents in around 90% of preschool children with cerebral palsy (CP) during the first year of life. Other nutritional factors are represented by excessive nutrient losses, often subsequent to gastroesophageal reflux and altered energy metabolism...
November 13, 2015: Nutrients
Måns Persson-Bunke, Tomasz Czuba, Gunnar Hägglund, Elisabet Rodby-Bousquet
BACKGROUND: In cerebral palsy (CP) there is an increased risk of scoliosis. It is important to identify a progressive scoliosis early-on because the results of surgery depend on the magnitude of the curve. The Swedish follow-up program for cerebral palsy (CPUP) includes clinical examinations of the spine. The reliability and validity of the assessment method have not been studied. In this study we evaluate the interrater reliability of the clinical spinal examination used in CPUP and scoliometer measurement in children with CP and we evaluate their validity compared to radiographic examination...
November 14, 2015: BMC Musculoskeletal Disorders
Nancy L Potter
No abstract text is available yet for this article.
March 2016: Developmental Medicine and Child Neurology
Angela A Navarrete-Opazo, Waleska Gonzalez, Paula Nahuelhual
OBJECTIVE: To systematically review the effectiveness of oral baclofen versus placebo or other antispastic oral medications in terms of body function, level of activity, and quality of life in children and adolescents with spastic cerebral palsy who are younger than 18 years. DATA SOURCES: Cochrane Library, Health Science Databases, DARE, LILACS, Embase, MEDLINE, OTseeker, PEDro, PsycINFO, SpeechBITE, ScienceDirect, Scopus, Trip,, Google Scholar, OpenGrey, and manual search...
April 2016: Archives of Physical Medicine and Rehabilitation
Domenico M Romeo, Daniela Ricci, Claudia Brogna, Eugenio Mercuri
The Hammersmith Infant Neurological Examination (HINE) has been proposed as one of the early neurological examination tools for the diagnosis of cerebral palsy (CP). The aim of the present study was to critically review the existing literature and our experience with the use of the HINE in infants at risk of CP. The published papers confirm that the HINE can play an important role in the diagnosis and prognosis of infants at risk of developing CP, and provide information on aspects of neurological findings impaired in different forms of CP and brain lesions...
March 2016: Developmental Medicine and Child Neurology
Sylvia Õunpuu, Matthew Solomito, Katharine Bell, Peter DeLuca, Kristan Pierz
BACKGROUND/AIMS: Multilevel surgical intervention is a common approach for the correction of gait abnormalities in children with cerebral palsy (CP). The short-term outcomes for the combination of rectus femoris transfer, hamstring lengthening and gastrocnemius lengthening have been well documented using three-dimensional motion analysis. However, the impact of time, growth, and puberty on these short-term outcomes of this combination of procedures is not well understood. The purpose of this study was to evaluate the long-term outcomes of these procedures on gait in patients with CP...
September 2015: Gait & Posture
Helen Cockerill
No abstract text is available yet for this article.
February 2016: Developmental Medicine and Child Neurology
Ram Kumar
No abstract text is available yet for this article.
December 2015: Developmental Medicine and Child Neurology
Susan M Reid, Michael R Ditchfield, Jenny Bracken, Dinah S Reddihough
In a population cohort of children with white matter injury (WMI) and cerebral palsy (CP), we aimed to describe the magnetic resonance imaging (MRI) characteristics, identify key structure-function relationships, and classify the severity of WMI in a clinically relevant way. Stratified on MRI laterality/symmetry, variables indicating the extent and location of cerebral abnormalities for 272 children with CP and WMI on chronic-phase MRI were related to gross motor function and motor topography using univariable and multivariable approaches...
October 2015: Research in Developmental Disabilities
2015-08-15 18:39:44
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