collection
MENU ▼
Read by QxMD icon Read
search

Dermatitis atópica

shared collection
65 papers 25 to 100 followers
https://www.readbyqxmd.com/read/29285724/management-of-itch-in-atopic-dermatitis
#1
REVIEW
Janelle Pavlis, Gil Yosipovitch
Atopic dermatitis (AD) is the most common itchy dermatosis that affects millions of children and adults worldwide. Chronic itch in this condition has significant impact on measures of quality of life, such as sleep. Treating itch in AD has been challenging for decades, but new drugs have emerged in the last year with significant anti-pruritic effect. The optimal treatment regimen for atopic itch addresses barrier dysfunction, inflammation, neural hypersensitivity, and the itch-scratch cycle. Topical moisturizers remain the foundation of treatment and should be used by all patients with AD-associated pruritus...
June 2018: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/29413338/the-skin-as-a-target-for-prevention-of-the-atopic-march
#2
REVIEW
Adrian J Lowe, Donald Y M Leung, Mimi L K Tang, John C Su, Katrina J Allen
OBJECTIVE: Allergic diseases have increased dramatically in the developed world during the past few decades, yet the understanding of risk factors and effective prevention approaches remain limited. In this review, we summarize the evidence supporting the hypothesis that skin-barrier impairment and early-life atopic dermatitis (AD) could play a causal role in the development of sensitization and subsequent food allergies and allergic airways disease (allergic asthma and rhinitis). We further discuss the potential to target the skin barrier as a means to lower the incidence of allergic disease...
February 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29306952/vitamin-d-and-the-pathophysiology-of-inflammatory-skin-diseases
#3
REVIEW
Meenakshi Umar, Konduru S Sastry, Fatima Al Ali, Moza Al-Khulaifi, Ena Wang, Aouatef I Chouchane
BACKGROUND: Vitamin D is a secosteroid, which was initially known for its skeletal role; however, in recent years, its functions in different organs have been increasingly recognized. In this review, we will provide an overview of vitamin D functions in the skin physiology with specific focus on its role in certain inflammatory skin conditions such as psoriasis and atopic dermatitis. METHODS: A comprehensive literature search was carried out in PubMed and Google Scholar databases using keywords like "vitamin D," "skin," "atopic dermatitis," and "psoriasis...
2018: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/29455854/pathophysiology-and-management-of-mild-to-moderate-pediatric-atopic-dermatitis
#4
Kammi Yap Sayaseng, Peggy Vernon
Atopic dermatitis (AD), or eczema, is a chronic inflammatory skin condition characterized by relapsing pruritic and dry, scaly lesions. AD affects 10% to 20% of children in the United States and significantly affects the quality of life of patients and their families. Primary care providers (PCPs) are often the first point of contact for the management of AD symptoms. As many as 70% of patients with mild to moderate disease can be managed by a PCP, underscoring the need for these providers to understand basic AD pathophysiology and current standards of care...
March 2018: Journal of Pediatric Health Care
https://www.readbyqxmd.com/read/29332945/the-human-skin-microbiome
#5
REVIEW
Allyson L Byrd, Yasmine Belkaid, Julia A Segre
Functioning as the exterior interface of the human body with the environment, skin acts as a physical barrier to prevent the invasion of foreign pathogens while providing a home to the commensal microbiota. The harsh physical landscape of skin, particularly the desiccated, nutrient-poor, acidic environment, also contributes to the adversity that pathogens face when colonizing human skin. Despite this, the skin is colonized by a diverse microbiota. In this Review, we describe amplicon and shotgun metagenomic DNA sequencing studies that have been used to assess the taxonomic diversity of microorganisms that are associated with skin from the kingdom to the strain level...
March 2018: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/29216643/emerging-treatment-options-in-atopic-dermatitis-topical-therapies
#6
REVIEW
Uffe Nygaard, Mette Deleuran, Christian Vestergaard
Atopic dermatitis is a chronic inflammatory skin disorder affecting children and adults, with the majority presenting mild to moderate disease severity. The use of topical corticosteroids (TCSs) in combination with emollients has been the mainstay for treating mild to moderate atopic dermatitis since the 1950s, and as a supplement to systemic treatment in severe disease. However, while very effective, TCSs are often accompanied by poor adherence due to corticophobia (fear of using corticosteroids in patients or doctors), unwanted side effects, and in some cases insufficient clinical response...
2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/29063438/atopic-dermatitis-managing-the-itch
#7
REVIEW
William S Farmer, Kalyani S Marathe
Atopic dermatitis has a substantial impact on sleep, appearance, psychological well-being, and other qualities of life. The visual appearance of lichenification, cheilitis, hyperpigmentation, ichthyosis, and erythema can be socially stigmatizing, and treatment of these symptoms is challenging. In managing pruritus in patients, practitioners should assess and document pruritus through questionnaires at each routine visit. Initially, practitioners should advise patients to employ non-pharmaceutical treatments such as emollients with wet wraps, elimination of triggers, changing scratching habits, and psychological interventions...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29168294/association-of-prenatal-folate-status-with-early-childhood-wheeze-and-atopic-dermatitis
#8
A Roy, M Kocak, T J Hartman, S Vereen, M Adgent, C Piyathilake, F A Tylavsky, K N Carroll
BACKGROUND: Prenatal folic acid supplementation is recommended to prevent birth defects. Some foods are fortified in the USA to ensure sufficient intake among reproductive-aged women. However, high prenatal folate exposure may be a risk factor for childhood atopic diseases. We investigated associations between prenatal folate and early childhood wheeze and atopic dermatitis in a US cohort. METHODS: We studied 858 mother-child dyads, enrolled prenatally. Folate was measured in 2nd and 3rd trimester maternal plasma...
March 2018: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28895959/atopic-dermatitis-emerging-therapies
#9
Eric Simpson, Jeremy Udkoff, Jenna Borok, Wynnis Tom, Lisa Beck, Lawrence F Eichenfield
Crisaborole and dupilumab represent the first 2 Food and Drug Administration (FDA)-approved therapies for atopic dermatitis (AD) in more than 15 years, and there are many promising drugs currently in development. This new wave of therapeutics capitalizes on the large body of work clarifying the pathogenesis of AD over the last several decades. In particular, type 2 cytokine-driven inflammation and skin barrier dysfunction are key processes underlying AD pathogenesis.
September 2017: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28932705/probiotics-for-the-treatment-of-atopic-dermatitis-in-children-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#10
REVIEW
Ruixue Huang, Huacheng Ning, Minxue Shen, Jie Li, Jianglin Zhang, Xiang Chen
Objective: Atopic dermatitis (AD) is a prevalent, burdensome, and psychologically important pediatric concern. Probiotics have been suggested as a treatment for AD. Some reports have explored this topic; however, the utility of probiotics for AD remains to be firmly established. Methods: To assess the effects of probiotics on AD in children, the PubMed/Medline, Cochrane Library Scopus, and OVID databases were searched for reports published in the English language. Results: Thirteen studies were identified. Significantly higher SCORAD values favoring probiotics over controls were observed (mean difference [MD], -3...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28331140/management-of-atopic-dermatitis-in-japan
#11
REVIEW
Hidehisa Saeki
The guidelines for the treatment of atopic dermatitis (AD) issued by the Japanese Dermatological Association (JDA), which are basically designed for dermatologists, were first prepared in 2000 and revised in 2016. The guidelines for AD of the Japanese Society of Allergology (JSA), which are basically designed for allergologists, including internists, otorhinolaryngologists, ophthalmologists, and dermatologists, were first prepared in 2009 and revised in 2014. In this article, I review the definition, pathophysiology, etiology, epidemiology, diagnosis, severity classification, examination for diagnosis and severity assessment, and treatments for AD in Japan according to these two guidelines for AD (JDA and JSA)...
2017: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/28390476/assessing-the-current-treatment-of-atopic-dermatitis-unmet-needs
#12
EDITORIAL
Donald Y M Leung, Emma Guttman-Yassky
No abstract text is available yet for this article.
April 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28399154/silk-garments-plus-standard-care-compared-with-standard-care-for-treating-eczema-in-children-a-randomised-controlled-observer-blind-pragmatic-trial-clothes-trial
#13
RANDOMIZED CONTROLLED TRIAL
Kim S Thomas, Lucy E Bradshaw, Tracey H Sach, Jonathan M Batchelor, Sandra Lawton, Eleanor F Harrison, Rachel H Haines, Amina Ahmed, Hywel C Williams, Taraneh Dean, Nigel P Burrows, Ian Pollock, Joanne Llewellyn, Clare Crang, Jane D Grundy, Juliet Guiness, Andrew Gribbin, Eleanor J Mitchell, Fiona Cowdell, Sara J Brown, Alan A Montgomery
BACKGROUND: The role of clothing in the management of eczema (also called atopic dermatitis or atopic eczema) is poorly understood. This trial evaluated the effectiveness and cost-effectiveness of silk garments (in addition to standard care) for the management of eczema in children with moderate to severe disease. METHODS AND FINDINGS: This was a parallel-group, randomised, controlled, observer-blind trial. Children aged 1 to 15 y with moderate to severe eczema were recruited from secondary care and the community at five UK medical centres...
April 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28416366/2-year-animal-carcinogenicity-results-for-crisaborole-a-novel-phosphodiesterase-4-inhibitor-for-atopic-dermatitis
#14
Vic Ciaravino, Dina Coronado, Cheryl Lanphear, Sanjay Chanda
BACKGROUND: Crisaborole is a novel, topical nonsteroidal, anti-inflammatory, phosphodiesterase 4 (PDE4) inhibitor for the treatment of mild to moderate atopic dermatitis. OBJECTIVE: As part of a nonclinical safety testing program, these 2-year studies tested the carcinogenic potential of crisaborole. METHODS: Crisaborole ointment, 2%, 5%, or 7%, was applied once daily topically to mice, and crisaborole was administered orally to rats at doses of 30, 100, or 300mg/kg/day for up to 104 weeks...
August 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28480804/tolerability-and-benefit-of-a-tetramethoxyluteolin-containing-skin-lotion
#15
Theoharis C Theoharides, Julia M Stewart, Irene Tsilioni
As many as 40% of people have sensitive skin and at least half of them suffer from pruritus associated with allergies, atopic dermatitis (AD), chronic urticaria (CU), cutaneous mastocytosis (CM), and psoriasis. Unfortunately, the available topical formulations contain antihistamines that are often not as effective as those containing corticosteroids. Certain natural flavonoids have anti-inflammatory actions. We recently reported that the natural flavonoid tetramethoxyluteolin has potent antiallergic and anti-inflammatory actions in vitro and in vivo...
June 2017: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/28484688/what-are-the-effects-of-a-mediterranean-diet-on-allergies-and-asthma-in-children
#16
REVIEW
Jose A Castro-Rodriguez, Luis Garcia-Marcos
This review updates the relationship between the adherence to Mediterranean diet (MedDiet) assessed by questionnaire and asthma, allergic rhinitis, or atopic eczema in childhood. It deals with the effect of MedDiet in children on asthma/wheeze, allergic rhinitis, and atopic dermatitis/eczema, and also with the effect of MedDiet consumption by the mother during pregnancy on the inception of asthma/wheeze and allergic diseases in the offspring. Adherence to MedDiet by children themselves seems to have a protective effect on asthma/wheezing symptoms after adjustment for confounders, although the effect is doubtful on lung function and bronchial hyperresponsiveness...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28057434/atopic-dermatitis-immune-deviation-barrier-dysfunction-ige-autoreactivity-and-new-therapies
#17
REVIEW
Masutaka Furue, Takahito Chiba, Gaku Tsuji, Dugarmaa Ulzii, Makiko Kido-Nakahara, Takeshi Nakahara, Takafumi Kadono
Atopic dermatitis (AD) is a chronic or chronically relapsing, eczematous, severely pruritic skin disorder mostly associated with IgE elevation and skin barrier dysfunction due to decreased filaggrin expression. The lesional skin of AD exhibits Th2- and Th22-deviated immune reactions that are progressive during disease chronicity. Th2 and Th22 cytokines further deteriorate the skin barrier by inhibiting filaggrin expression. Some IgEs are reactive to self-antigens. The IgE autoreactivity may precipitate the chronicity of AD...
July 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28150106/psoriasis-and-atopic-dermatitis
#18
REVIEW
Christopher E M Griffiths, Peter van de Kerkhof, Magdalena Czarnecka-Operacz
Psoriasis and atopic dermatitis are common, chronic inflammatory skin diseases. We discuss several aspects of these disorders, including: risk factors; incidence and prevalence; the complex disease burden; and the comorbidities that increase the clinical significance of each disorder. We also focus on treatment management strategies and outline why individualized, patient-centered treatment regimens should be part of the care plans for patients with either psoriasis or atopic dermatitis. Finally, we conclude that, while our theoretical knowledge of the optimum care plans for these patients is increasingly sophisticated, this understanding is, unfortunately, not always reflected in daily clinical practice...
January 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28209325/japanese-guidelines-for-atopic-dermatitis-2017
#19
REVIEW
Ichiro Katayama, Michiko Aihara, Yukihiro Ohya, Hidehisa Saeki, Naoki Shimojo, Shunsuke Shoji, Masami Taniguchi, Hidekazu Yamada
Given the importance of appropriate diagnosis and appropriate assessment of cutaneous symptoms in treatment of atopic dermatitis, the basics of treatment in this guideline are composed of (1) investigation and countermeasures of causes and exacerbating factors, (2) correction of skin dysfunctions (skin care), and (3) pharmacotherapy, as three mainstays. These are based on the disease concept that atopic dermatitis is an inflammatory cutaneous disease with eczema by atopic diathesis, multi-factorial in onset and aggravation, and accompanied by skin dysfunctions...
April 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28209661/non-topical-management-of-recalcitrant-paediatric-atopic-dermatitis
#20
REVIEW
Jin Ho Chong, Mark Jean Aan Koh
Atopic dermatitis (AD) is a common chronic, pruritic skin disease in children. As the incidence of AD increases, especially in high-income countries, paediatricians may see an increasing number of recalcitrant AD cases in their practice. Although these cases are principally managed by paediatric dermatologists, it is important for paediatricians to be aware of the use and side effects of non-topical treatment like phototherapy and systemic agents as well as the evidence for alternative treatment, which caregivers may ask about...
July 2017: Archives of Disease in Childhood
label_collection
label_collection
5167
1
2
2017-02-23 22:34:14
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"