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Landmark Research

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2 papers 0 to 25 followers
James M Chamberlain, Pamela Okada, Maija Holsti, Prashant Mahajan, Kathleen M Brown, Cheryl Vance, Victor Gonzalez, Richard Lichenstein, Rachel Stanley, David C Brousseau, Joseph Grubenhoff, Roger Zemek, David W Johnson, Traci E Clemons, Jill Baren
IMPORTANCE: Benzodiazepines are considered first-line therapy for pediatric status epilepticus. Some studies suggest that lorazepam may be more effective or safer than diazepam, but lorazepam is not Food and Drug Administration approved for this indication. OBJECTIVE: To test the hypothesis that lorazepam has better efficacy and safety than diazepam for treating pediatric status epilepticus. DESIGN, SETTING, AND PARTICIPANTS: This double-blind, randomized clinical trial was conducted from March 1, 2008, to March 14, 2012...
April 23, 2014: JAMA: the Journal of the American Medical Association
Ellen Jo Baron, J Michael Miller, Melvin P Weinstein, Sandra S Richter, Peter H Gilligan, Richard B Thomson, Paul Bourbeau, Karen C Carroll, Sue C Kehl, W Michael Dunne, Barbara Robinson-Dunn, Joseph D Schwartzman, Kimberle C Chapin, James W Snyder, Betty A Forbes, Robin Patel, Jon E Rosenblatt, Bobbi S Pritt
The critical role of the microbiology laboratory in infectious disease diagnosis calls for a close, positive working relationship between the physician and the microbiologists who provide enormous value to the health care team. This document, developed by both laboratory and clinical experts, provides information on which tests are valuable and in which contexts, and on tests that add little or no value for diagnostic decisions. Sections are divided into anatomic systems, including Bloodstream Infections and Infections of the Cardiovascular System, Central Nervous System Infections, Ocular Infections, Soft Tissue Infections of the Head and Neck, Upper Respiratory Infections, Lower Respiratory Tract infections, Infections of the Gastrointestinal Tract, Intraabdominal Infections, Bone and Joint Infections, Urinary Tract Infections, Genital Infections, and Skin and Soft Tissue Infections; or into etiologic agent groups, including Tickborne Infections, Viral Syndromes, and Blood and Tissue Parasite Infections...
August 2013: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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