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IgA Nephropathy

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26 papers 0 to 25 followers
By P O Pediatrics, Nephrology
https://www.readbyqxmd.com/read/27583915/the-effect-of-calcineurin-inhibitors-in-the-treatment-of-iga-nephropathy-a-systematic-review-and-meta-analysis-prisma
#1
Wei Peng, Yi Tang, Zheng Jiang, Zi Li, Xuhua Mi, Wei Qin
BACKGROUND: Immunoglobin A nephropathy (IgAN), the most prevalent form of primary glomerulonephritis, represents the leading cause of kidney failure among East Asian populations. Immunosuppressive treatment regimen, except for a 6-month trial of corticosteroids, has not been approved by the KDIGO guideline yet. Specific and effective treatment is still lacking. We decided to evaluate the efficacy and safety of the calcineurin inhibitors (CNIs) in the treatment of IgAN. METHODS: Database from the Cochrane library, PubMed, Embase, CBM, CNKI, and CENTRAL databases were searched and reviewed up to March 2016...
August 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27416024/corticosteroid-treatment-influences-ta-proteinuria-and-renal-survival-in-iga-nephropathy
#2
Cristina Sarcina, Carmine Tinelli, Francesca Ferrario, Bianca Visciano, Antonello Pani, Annalisa De Silvestri, Ilaria De Simone, Lucia Del Vecchio, Veronica Terraneo, Silvia Furiani, Gaia Santagostino, Enzo Corghi, Claudio Pozzi
The clinical course of IgA nephropathy (IgAN) and its outcome are extremely variable. Proteinuria at baseline has been considered one of the most important risk factors. More recently, mean proteinuria of follow-up (time-average proteinuria: TAp) was described as a stronger marker of renal survival, suggesting to consider it as a marker of disease activity and response to treatment. We evaluated predictors of renal survival in IgAN patients with different degrees of renal dysfunction and histological lesions, focusing on the role of the therapy in influencing TAp...
2016: PloS One
https://www.readbyqxmd.com/read/27368023/devastating-renal-outcome-caused-by-skin-infection-with-methicillin-resistant-staphylococcus-aureus-a-case-report
#3
Jun-Hua Liang, Yu-Wei Fang, An-Hung Yang, Ming Hsien Tsai
Methicillin-resistant Staphylococcus aureus (MRSA) is an emerging pathogen that infects the skin and soft tissue. However, there are few reports of renal complications from MRSA involving immunoglobulin (Ig)A-dominated rapidly progressive glomerulonephritis (GN). Favorable renal outcomes from IgA GN are achieved by administering timely therapy. In the present study, we describe the case of a healthy young woman suffering from a cutaneous MRSA infection that initially presented with gross hematuria. Six months after eradicating the infection, severe impairment of renal function was noted because of intractable nausea and vomiting...
June 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27095365/evidence-based-clinical-practice-guidelines-for-iga-nephropathy-2014
#4
REVIEW
Yukio Yuzawa, Ryohei Yamamoto, Kazuo Takahashi, Ritsuko Katafuchi, Makoto Tomita, Yoshihide Fujigaki, Hiroshi Kitamura, Masashi Goto, Takashi Yasuda, Mitsuhiro Sato, Maki Urushihara, Shuji Kondo, Shoji Kagami, Yoshinari Yasuda, Hiroyuki Komatsu, Miki Takahara, Yasuaki Harabuchi, Kenjiro Kimura, Seiichi Matsuo
No abstract text is available yet for this article.
August 2016: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/27046351/should-immunosuppressive-therapy-be-used-in-slowly-progressive-iga-nephropathy
#5
EDITORIAL
John Feehally, Jonathan Barratt
No abstract text is available yet for this article.
August 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/26978656/proteinuria-during-follow-up-period-and-long-term-renal-survival-of-childhood-iga-nephropathy
#6
Koichi Kamei, Ryoko Harada, Riku Hamada, Tomoyuki Sakai, Yuko Hamasaki, Hiroshi Hataya, Shuichi Ito, Kenji Ishikura, Masataka Honda
BACKGROUND: Proteinuria is the most important risk factor for IgA nephropathy progression. The purpose of this study is to evaluate the long-term outcome and risk factors for poor prognosis in childhood IgA nephropathy. METHODS: Patients who were diagnosed with IgA nephropathy between 1972 and 1992 at the Tokyo Metropolitan Kiyose Children's Hospital were included. We analyzed risk factors for progression to end-stage kidney disease (ESKD) and chronic renal insufficiency (CRI) using Kaplan-Meier method and multivariate analyses of Cox proportional hazard model...
2016: PloS One
https://www.readbyqxmd.com/read/26962736/intensive-supportive-care-plus-immunosuppression-in-iga-nephropathy
#7
LETTER
Jürgen Floege, Thomas Rauen, Frank Eitner
No abstract text is available yet for this article.
March 10, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/26376134/new-developments-in-the-genetics-pathogenesis-and-therapy-of-iga-nephropathy
#8
REVIEW
Riccardo Magistroni, Vivette D D'Agati, Gerald B Appel, Krzysztof Kiryluk
Recent years have brought notable progress in the field of IgA nephropathy. Here, we highlight important new directions and latest developments, including successful discovery of several genetic susceptibility loci, formulation of the multihit pathogenesis model, introduction of the Oxford pathology scoring system, and formalization of the Kidney Disease Improving Global Outcomes (KDIGO) consensus treatment guidelines. We focus on the latest genetic findings that confirm a strong contribution of inherited factors and explain some of the geoethnic disparities in disease susceptibility...
November 2015: Kidney International
https://www.readbyqxmd.com/read/26914454/the-clinical-significance-of-uric-acid-and-complement-activation-in-the-progression-of-iga-nephropathy
#9
Yasar Caliskan, Yasemin Ozluk, Dilara Celik, Nida Oztop, Aysun Aksoy, Ayse Serra Ucar, Halil Yazici, Isin Kilicaslan, Mehmet Sukru Sever
BACKGROUND/AIMS: The aim of this study is to investigate the utility of clinical [age, gender, mean arterial pressure (MAP)] and laboratory parameters [eGFR, hemoglobin (Hgb), serum levels of creatinine, uric acid, albumin, proteinuria, hematuria] and also histopathological lesions (Oxford classification parameters, crescents, intensity and pattern of staining for C3, C1Q, IgA, IgG, IgM) as progression markers in patients with IgA Nephropathy (IgAN). METHODS: A total of 111 IgAN patients with a follow-up period >1 year or who reached kidney failure [GFR category G5 chronic kidney disease (CKD)] <1 year were investigated...
2016: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/26630142/intensive-supportive-care-plus-immunosuppression-in-iga-nephropathy
#10
RANDOMIZED CONTROLLED TRIAL
Thomas Rauen, Frank Eitner, Christina Fitzner, Claudia Sommerer, Martin Zeier, Britta Otte, Ulf Panzer, Harm Peters, Urs Benck, Peter R Mertens, Uwe Kuhlmann, Oliver Witzke, Oliver Gross, Volker Vielhauer, Johannes F E Mann, Ralf-Dieter Hilgers, Jürgen Floege
BACKGROUND: The outcomes of immunosuppressive therapy, when added to supportive care, in patients with IgA nephropathy are uncertain. METHODS: We conducted a multicenter, open-label, randomized, controlled trial with a two-group, parallel, group-sequential design. During a 6-month run-in phase, supportive care (in particular, blockade of the renin-angiotensin system) was adjusted on the basis of proteinuria. Patients who had persistent proteinuria with urinary protein excretion of at least 0...
December 3, 2015: New England Journal of Medicine
https://www.readbyqxmd.com/read/26582216/the-role-of-tonsillectomy-in-iga-nephropathy
#11
Sandro Feriozzi, Rosaria Polci
The IgA nephropathy (IgAN) is a very common glomerulonephritis and can result in end-stage renal disease. From a clinical point of view, IgAN is characterised by repeated events of macrohaematuria associated with infections of the upper airways. In IgAN, the IgA released by the tonsillar lymphatic tissue into blood circulation are defective in glycosylation. These aberrant IgA can reach the glomeruli and deposit into mesangium causing an inflammation with cellular proliferation. The treatment is not yet well defined: steroids and immunosuppressive drugs are suggested in cases with a progressive disease...
February 2016: Journal of Nephrology
https://www.readbyqxmd.com/read/26567162/role-of-complement-in-iga-nephropathy
#12
REVIEW
Mohamed R Daha, Cees van Kooten
Immunoglobulin A nephropathy (IgAN) is characterized by the deposition of IgA in the mesangium of glomeruli. This mesangial IgA has been found to consist mainly of polymeric IgA1 which drives the activation of the mesangial cells and results in excessive production of several inflammatory mediators. The activation of mesangial cells is amplified by the ability of IgA to activate the complement system, originally thought to occur mainly via the alternative pathway of complement. However more recent studies indicate that lectin pathway involvement has a strong association with progression of renal disease...
February 2016: Journal of Nephrology
https://www.readbyqxmd.com/read/26456327/clinical-manifestations-of-henoch-sch%C3%A3-nlein-purpura-nephritis-and-iga-nephropathy-comparative-analysis-of-data-from-the-japan-renal-biopsy-registry-j-rbr
#13
Hiroyuki Komatsu, Shouichi Fujimoto, Norishige Yoshikawa, Hiroshi Kitamura, Hitoshi Sugiyama, Hitoshi Yokoyama
BACKGROUND: The clinical presentation of Henoch-Schönlein purpura nephritis (HSPN) has not been thoroughly investigated among patients of different ages. We therefore compared the features of HSPN and IgA nephropathy (IgAN) based on data from the Japan Renal Biopsy Registry (J-RBR). METHODS: This cross-sectional study analyzed data from patients who were registered in the J-RBR between 2007 and 2012. Clinico-pathological findings at diagnosis were compared among children (aged ≤18 years), adult (aged 19-64 years) and elderly (aged ≥65 years) patients with HSPN (n = 513) and IgAN (n = 5679)...
August 2016: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/26413270/clinical-features-of-iga-nephropathy-with-serum-anca-positivity-a-retrospective-case-control-study
#14
Ya-Zi Yang, Su-Fang Shi, Yu-Qing Chen, Min Chen, Yi-He Yang, Xin-Fang Xie, Rong Zou, Ji-Cheng Lv, Li-Jun Liu, Hong Zhang
BACKGROUND: The coexistence of IgA nephropathy (IgAN) and antineutrophil cytoplasmic autoantibodies (ANCAs) is relatively rare. Only a few studies have reported the features of these patients. METHODS: We studied the clinical and histological features of 20 ANCA-positive IgAN patients. They were compared with ANCA-negative IgAN patients (n = 40) and ANCA-associated systemic vasculitis (AASV) patients (n = 40) with a randomly selected and matched proportion of crescentic glomeruli...
October 2015: Clinical Kidney Journal
https://www.readbyqxmd.com/read/26413269/rapidly-progressive-iga-nephropathy-a-form-of-vasculitis-or-a-complement-mediated-disease
#15
Jorge Rojas-Rivera, Gema Fernández-Juárez, Manuel Praga
A rapidly progressive and crescentic IgA nephropathy (IgAN) is uncommon, but it has a high risk of progression to end-stage renal disease and variable response to immunosuppression. The importance of a positive anti-neutrophil cytoplasmic antibody (ANCA) serology in this group of patients is not fully understood but may have prognostic significance. On the other hand, there is growing evidence of the role of complement in the pathogenesis of IgAN, especially in cases of crescentic IgAN. Therapies directed against the complement system are a potential and rational therapeutic approach...
October 2015: Clinical Kidney Journal
https://www.readbyqxmd.com/read/26413271/use-of-eculizumab-in-crescentic-iga-nephropathy-proof-of-principle-and-conundrum
#16
Troels Ring, Birgitte Bang Pedersen, Giedrius Salkus, Timothy H J Goodship
IgA nephropathy (IgAN) is characterized by a variable clinical course and multifaceted pathophysiology. There is substantial evidence to suggest that complement activation plays a pivotal role in the pathogenesis of the disease. Therefore, complement inhibition using the humanized anti-C5 monoclonal antibody eculizumab could be a rational treatment. We report here a 16-year-old male with the vasculitic form of IgAN who failed to respond to aggressive conventional therapy including high-dose steroids, cyclophosphamide and plasma exchange and who was treated with four weekly doses of 900 mg eculizumab followed by a single dose of 1200 mg...
October 2015: Clinical Kidney Journal
https://www.readbyqxmd.com/read/26266064/pulmonary-limited-mpo-anca-microscopic-polyangiitis-and-idiopathic-lung-fibrosis-in-a-patient-with-a-diagnosis-of-iga-nephropathy
#17
Alwin Tilanus, Patricia Van der Niepen, Caroline Geers, Karl Martin Wissing
We present a case of a male patient with chronic renal insufficiency, due to crescentic glomerulonephritis with IgA deposits, who successively developed (idiopathic) thrombocytopenic purpura (ITP) and MPO-ANCA microscopic polyangiitis (MPA) with pulmonary fibrosis. The patient presented with cough, weight loss, and dyspnea on exertion. CT imaging and pulmonary function tests were compatible with interstitial pneumonitis with pulmonary fibrosis. Laboratory results showed high MPO-ANCA titers; the urinary sediment was bland...
2015: Case Reports in Nephrology
https://www.readbyqxmd.com/read/26398653/case-report-iga-nephropathy-anca-positive-with-favorable-outcome
#18
Flávia Lara Barcelos, Tânia Maria de Souza Fontes
INTRODUCTION: The antineutrophil cytoplasmatic antibody (ANCA) is usually associated with pauci-immune crescentic glomerulonephritis (CrGN). However, the literature show an incidence unexpected high of ANCA in immunocomplex CrNP. The crescent IgA nephropaty is one of CrGN that associated with ANCAObjective:To relate an IgA nephropaty ANCA positive and sign of worse prognosis that improved with immunossupression. METHOD: 38-year-old pacient with arterial hypertension, renal impairment (CKD-EPI 37 ml/min/1,73 m2), non-nephrotic proteinuria and hematuria...
July 2015: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/26380197/update-on-immunoglobulin-a-nephropathy-part-i-pathophysiology
#19
Maurizio Salvadori, Giuseppina Rosso
Immunoglobulin A (IgA) nephropathy is one of the most common glomerulonephritis and its frequency is probably underestimated because in most patients the disease has an indolent course and the kidney biopsy is essential for the diagnosis. In the last years its pathogenesis has been better identified even if still now several questions remain to be answered. The genetic wide association studies have allowed to identifying the relevance of genetics and several putative genes have been identified. The genetics has also allowed explaining why some ancestral groups are affected with higher frequency...
September 6, 2015: World Journal of Nephrology
https://www.readbyqxmd.com/read/26349433/pathological-sub-analysis-of-a-multicenter-randomized-controlled-trial-of-tonsillectomy-combined-with-steroid-pulse-therapy-versus-steroid-pulse-monotherapy-in-patients-with-immunoglobulin-a-nephropathy
#20
Ritsuko Katafuchi, Tetsuya Kawamura, Kensuke Joh, Akinori Hashiguchi, Satoshi Hisano, Akira Shimizu, Yoichi Miyazaki, Masaharu Nagata, Seiichi Matsuo
BACKGROUND: The IgA nephropathy (IgAN) Study Group in Japan conducted a multicenter, randomized, controlled trial of tonsillectomy with steroid pulse therapy (TSP) versus steroid pulse monotherapy in patients with IgAN (UMIN Clinical Trial Registry Number; C000000384). The effects of therapies in relation to pathological severity were analyzed in this study. METHODS: The patients with IgAN, urinary protein 1.0-3.5 g/day, serum creatinine of 1.5 mg/dl or less were randomly assigned to receiving TSP (Group A) or steroid pulses alone (Group B)...
April 2016: Clinical and Experimental Nephrology
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