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90 papers 100 to 500 followers Recent ART articles. Let me know if I missed an important one. -milad@northwestern.edu.
https://www.readbyqxmd.com/read/27509101/fresh-versus-frozen-embryos-for-infertility-in-the-polycystic-ovary-syndrome
#1
RANDOMIZED CONTROLLED TRIAL
Zi-Jiang Chen, Yuhua Shi, Yun Sun, Bo Zhang, Xiaoyan Liang, Yunxia Cao, Jing Yang, Jiayin Liu, Daimin Wei, Ning Weng, Lifeng Tian, Cuifang Hao, Dongzi Yang, Feng Zhou, Juanzi Shi, Yongle Xu, Jing Li, Junhao Yan, Yingying Qin, Han Zhao, Heping Zhang, Richard S Legro
BACKGROUND: The transfer of fresh embryos is generally preferred over the transfer of frozen embryos for in vitro fertilization (IVF), but some evidence suggests that frozen-embryo transfer may improve the live-birth rate and lower the rates of the ovarian hyperstimulation syndrome and pregnancy complications in women with the polycystic ovary syndrome. METHODS: In this multicenter trial, we randomly assigned 1508 infertile women with the polycystic ovary syndrome who were undergoing their first IVF cycle to undergo either fresh-embryo transfer or embryo cryopreservation followed by frozen-embryo transfer...
August 11, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27441046/resurgence-of-minimal-stimulation-in-vitro-fertilization-with-a-protocol-consisting-of-gonadotropin-releasing-hormone-agonist-trigger-and-vitrified-thawed-embryo-transfer
#2
REVIEW
John Zhang
Minimal stimulation in vitro fertilization (mini-IVF) consists of a gentle controlled ovarian stimulation that aims to produce a maximum of five to six oocytes. There is a misbelief that mini-IVF severely compromises pregnancy and live birth rates. An appraisal of the literature pertaining to studies on mini-IVF protocols was performed. The advantages of minimal stimulation protocols are reported here with a focus on the use of clomiphene citrate (CC), gonadotropin releasing hormone (GnRH) ago- nist trigger for oocyte maturation, and freeze-all embryo strategy...
July 2016: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/27434094/luteal-phase-support-with-estradiol-and-progesterone-versus-progesterone-alone-in-gnrh-antagonist-icsi-cycles-a-randomized-controlled-study
#3
Wael A Ismail Madkour, Bassel Noah, Amr M S Abdel Hamid, Hena Zaheer, Awatif Al-Bahr, Mahmoud Shaeer, Ashraf Moawad
In vitro fertilization (IVF) cycles are associated with a defective luteal phase. Although progesterone supplementation to treat this problem is standard practice, estrogen addition is debatable. Our aim was to compare pregnancy outcomes in 220 patients undergoing antagonist intracytoplasmic sperm injection (ICSI) cycles protocol. The patients were randomly assigned into two equal groups to receive either vaginal progesterone alone (90 mg once daily) starting on the day of oocyte retrieval for up to 12 weeks if pregnancy occurred or estradiol addition (2 mg twice daily) starting on the same day and continuing up to seven weeks (foetal viability scan)...
June 2016: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/27403585/reproductive-endocrinology-in-recurrent-pregnancy-loss
#4
Maria C Krog, Henriette Svarre Nielsen, Ole B Christiansen, Astrid M Kolte
Endocrine disruptions may be important in patients experiencing recurrent pregnancy loss (RPL). This review focuses on data available on RPL and the endocrine system to investigate relevant, and perhaps modifiable, endocrine factors of importance for the disorder. Evidence indicates that some hormones may be important as immune modulators and a better understanding of this interplay has potential for improving pregnancy outcome in RPL. To date there is a lack of consensus on the effect of endocrine treatment options in RPL and there is a strong need for large randomized-controlled trials...
September 2016: Clinical Obstetrics and Gynecology
https://www.readbyqxmd.com/read/26724797/conventional-ovarian-stimulation-and-single-embryo-transfer-for-ivf-icsi-how-many-oocytes-do-we-need-to-maximize-cumulative-live-birth-rates-after-utilization-of-all-fresh-and-frozen-embryos
#5
Panagiotis Drakopoulos, Christophe Blockeel, Dominic Stoop, Michel Camus, Michel de Vos, Herman Tournaye, Nikolaos P Polyzos
STUDY QUESTION: What is the impact of ovarian response on cumulative live birth rates (LBR) following utilization of all fresh and frozen embryos in women undergoing their first ovarian stimulation cycle, planned to undergo single embryo transfer (SET). SUMMARY ANSWER: Cumulative LBR significantly increases with the number of oocytes retrieved. WHAT IS KNOWN ALREADY: Several studies have addressed the issue of the optimal number of oocytes retrieved following controlled ovarian stimulation (COS) for IVF/ICSI and demonstrated that ovarian response is independently related to LBR following IVF/ICSI...
February 2016: Human Reproduction
https://www.readbyqxmd.com/read/27406348/clinical-practice-polycystic-ovary-syndrome
#6
REVIEW
Christopher R McCartney, John C Marshall
No abstract text is available yet for this article.
July 7, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27363928/hysteroscopic-guided-local-endometrial-injury-does-not-improve-natural-cycle-pregnancy-rate-in-women-with-unexplained-infertility-randomized-controlled-trial
#7
Tarek Shokeir, Mohamed Ebrahim, Hosam El-Mogy
AIM: To evaluate the efficacy of a hysteroscopic site-specific local endometrial injury (LEI) in a group of women with unexplained infertility (UI) undergoing expectant management with no fertility treatment versus no intervention. METHODS: This open-label, randomized controlled trial (RCT) was conducted between June 2013 and July 2015. Hysteroscopic site-specific LEI was determined by patient identification number, and 120 women were included. Eligible participants were randomly assigned to receive either a single, site-specific LEI guided by hysteroscopy (study group, n = 60) or no intervention (control group, n = 60)...
July 1, 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/26961635/statisticians-issue-warning-over-misuse-of-p-values
#8
Monya Baker
No abstract text is available yet for this article.
March 10, 2016: Nature
https://www.readbyqxmd.com/read/27106604/recombinant-versus-urinary-human-chorionic-gonadotrophin-for-final-oocyte-maturation-triggering-in-ivf-and-icsi-cycles
#9
REVIEW
Mohamed A Youssef, Ahmed M Abou-Setta, Wai Sun Lam
BACKGROUND: For the last few decades urinary human chorionic gonadotrophin (uhCG) has been used to trigger final oocyte maturation in cycles of in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI). Recombinant technology has allowed the production of two drugs, recombinant human chorionic gonadotrophin (rhCG) and recombinant luteinising hormone (rLH), that can be used for the same purpose, to mimic the endogenous luteinising hormone (LH) surge. This allows commercial manufacturers to adjust production according to market requirements and to remove all urinary contaminants, facilitating the safe subcutaneous administration of a compound with less batch-to-batch variation...
2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27238372/endometrial-thickness-as-a-predictor-of-pregnancy-outcomes-in-10787-fresh-ivf-icsi-cycles
#10
Xi Yuan, Sotirios H Saravelos, Qiong Wang, Yanwen Xu, Tin-Chiu Li, Canquan Zhou
This retrospective study assessed the predictive value of endometrial thickness (EMT) on HCG administration day for the clinical outcome of fresh IVF and intracytoplasmic sperm injection (ICSI) cycles. A total of 8690 consecutive women undergoing 10,787 cycles over a 5-year period were included. The 5th, 50th and 95th centiles for EMT were determined as 8, 11 and 15 mm, respectively. Group analysis according to these centiles (Group 1: < 8 mm; Group 2: ≥ 8 and ≤11 mm; Group 3: > 11 and ≤15 mm; Group 4: > 15 mm) demonstrated significant differences (P < 0...
August 2016: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/27126581/gonadotrophin-releasing-hormone-antagonists-for-assisted-reproductive-technology
#11
REVIEW
Hesham G Al-Inany, Mohamed A Youssef, Reuben Olugbenga Ayeleke, Julie Brown, Wai Sun Lam, Frank J Broekmans
BACKGROUND: Gonadotrophin-releasing hormone (GnRH) antagonists can be used to prevent a luteinizing hormone (LH) surge during controlled ovarian hyperstimulation (COH) without the hypo-oestrogenic side-effects, flare-up, or long down-regulation period associated with agonists. The antagonists directly and rapidly inhibit gonadotrophin release within several hours through competitive binding to pituitary GnRH receptors. This property allows their use at any time during the follicular phase...
2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27114329/flexibility-in-starting-ovarian-stimulation-at-different-phases-of-the-menstrual-cycle-for-treatment-of-infertile-women-with-the-use-of-in%C3%A2-vitro-fertilization-or-intracytoplasmic-sperm-injection
#12
Ningxin Qin, Qiuju Chen, Qingqing Hong, Renfei Cai, Hongyuan Gao, Yun Wang, Lihua Sun, Shaozhen Zhang, Haiyan Guo, Yonglun Fu, Ai Ai, Hui Tian, Qifeng Lyu, Salim Daya, Yanping Kuang
OBJECTIVE: To investigate flexibility in starting controlled ovarian stimulation at any phase of the menstrual cycle in infertile women undergoing treatment with assisted reproduction. DESIGN: Retrospective cohort study. SETTING: Academic tertiary-care medical center. PATIENT(S): At total of 150 infertile patients undergoing in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) treatment. Ninety of the women also underwent frozen embryo transfer (FET) procedures...
August 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/18829004/effect-of-methotrexate-exposure-on-subsequent-fertility-in-women-undergoing-controlled-ovarian-stimulation
#13
Janet F McLaren, Richard O Burney, Amin A Milki, Lynn M Westphal, Michael H Dahan, Ruth B Lathi
OBJECTIVE: To evaluate the pregnancy rate, ovarian responsiveness, and endometrial thickness in infertility patients with a history of methotrexate exposure who subsequently underwent controlled ovarian stimulation. DESIGN: Retrospective cohort study. SETTING: University reproductive endocrinology and infertility program. SUBJECT(S): Forty-eight women with infertility undergoing ovarian stimulation after receiving methotrexate treatment for ectopic gestation...
August 2009: Fertility and Sterility
https://www.readbyqxmd.com/read/24035728/does-methotrexate-administration-for-ectopic-pregnancy-after-in-vitro-fertilization-impact-ovarian-reserve-or-ovarian-responsiveness
#14
Christina E Boots, Robert L Gustofson, Eve C Feinberg
OBJECTIVE: To evaluate the effects of methotrexate (MTX) on the future fertility of women undergoing IVF by comparing ovarian reserve and ovarian responsiveness in the IVF cycle before and after an ectopic pregnancy (EP) treated with MTX. DESIGN: Retrospective cohort study. SETTING: Private reproductive endocrinology and infertility practice. PATIENT(S): Sixty-six women undergoing IVF before and after receiving MTX for an EP...
December 2013: Fertility and Sterility
https://www.readbyqxmd.com/read/25917279/effect-of-methotrexate-or-salpingectomy-for-ectopic-pregnancy-on-subsequent-in-vitro-fertilization-embryo-transfer-outcomes
#15
COMPARATIVE STUDY
Nigel Pereira, Deanna Gerber, Rachel S Gerber, Jovana P Lekovich, Rony T Elias, Steven D Spandorfer, Zev Rosenwaks
OBJECTIVE: To investigate the effect of methotrexate (MTX) or salpingectomy for ectopic pregnancy on the outcomes of subsequent in vitro fertilization (IVF)-embryo transfer (ET) cycles. DESIGN: Retrospective cohort study (Canadian Task Force Classification II-3). SETTING: Academic center. PATIENTS: All patients undergoing fresh IVF-ET between January 2004 and July 2013 after treatment of an ectopic pregnancy with MTX or salpingectomy in the preceding IVF-ET cycle were analyzed for potential inclusion...
July 2015: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/26605928/a-randomized-trial-of-progesterone-in-women-with-recurrent-miscarriages
#16
RANDOMIZED CONTROLLED TRIAL
Arri Coomarasamy, Helen Williams, Ewa Truchanowicz, Paul T Seed, Rachel Small, Siobhan Quenby, Pratima Gupta, Feroza Dawood, Yvonne E M Koot, Ruth Bender Atik, Kitty W M Bloemenkamp, Rebecca Brady, Annette L Briley, Rebecca Cavallaro, Ying C Cheong, Justin J Chu, Abey Eapen, Ayman Ewies, Annemieke Hoek, Eugenie M Kaaijk, Carolien A M Koks, Tin-Chiu Li, Marjory MacLean, Ben W Mol, Judith Moore, Jackie A Ross, Lisa Sharpe, Jane Stewart, Nirmala Vaithilingam, Roy G Farquharson, Mark D Kilby, Yacoub Khalaf, Mariette Goddijn, Lesley Regan, Rajendra Rai
BACKGROUND: Progesterone is essential for the maintenance of pregnancy. However, whether progesterone supplementation in the first trimester of pregnancy would increase the rate of live births among women with a history of unexplained recurrent miscarriages is uncertain. METHODS: We conducted a multicenter, double-blind, placebo-controlled, randomized trial to investigate whether treatment with progesterone would increase the rates of live births and newborn survival among women with unexplained recurrent miscarriage...
November 26, 2015: New England Journal of Medicine
https://www.readbyqxmd.com/read/26387772/screening-and-subsequent-management-for-thyroid-dysfunction-pre-pregnancy-and-during-pregnancy-for-improving-maternal-and-infant-health
#17
REVIEW
Laura Spencer, Tanya Bubner, Emily Bain, Philippa Middleton
BACKGROUND: Thyroid dysfunction pre-pregnancy and during pregnancy (both hyper- and hypothyroidism) is associated with increased risk of adverse outcomes for mothers and infants in the short- and long-term. Managing the thyroid dysfunction (e.g. thyroxine for hypothyroidism, or antithyroid medication for hyperthyroidism) may improve outcomes. The best method of screening to identify and subsequently manage thyroid dysfunction pre-pregnancy and during pregnancy is unknown. OBJECTIVES: To assess the effects of different screening methods (and subsequent management) for thyroid dysfunction pre-pregnancy and during pregnancy on maternal and infant outcomes...
2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26924636/strategies-to-improve-the-outcomes-of-assisted-reproduction-in-women-with-polycystic-ovarian-syndrome-a-systematic-review-and-meta-analysis
#18
M Kollmann, W P Martins, M L S Lima, L Craciunas, C O Nastri, A Richardson, N Raine-Fenning
OBJECTIVES: To identify, appraise and summarize the current evidence regarding the efficacy of all strategies aiming to improve ART treatment in women with polycystic ovary syndrome (PCOS). METHODS: A comprehensive literature search of the standard medical databases was performed. The last electronic search was run in July-2015. The primary outcome measures were live birth / ongoing pregnancy and ovarian hyperstimulation syndrome (OHSS). The secondary outcome measures were clinical pregnancy and miscarriage...
February 29, 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/26885110/conventional-in-vitro-fertilization-maybe-yields-more-available-embryos-than-intracytoplasmic-sperm-injection-for-patients-with-no-indications-for-icsi
#19
Li Ming, Chen Yuan, Zhao Ping, Liu Ping, Qiao Jie
Many physicians suggest that performing ICSI instead of IVF for all cases just because they thought that ICSI yields more available embryos than IVF. However, we found that IVF results in better fertilization per retrieved oocyte (72.12 ± 19.60% versus 59.54 ± 21.38%, P < 0.01) and day 3 available embryo per retrieved oocyte rates (54.89 ± 23.53% versus 50.54 ± 22.68%, P < 0.05) than ICSI after analysis of 218 cycles using sibling oocytes in combined IVF/ICSI for patients with no indications for ICSI...
2015: International Journal of Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/26892696/reproductive-potential-of-mature-oocytes-after-conventional-ovarian-hyperstimulation-for-in-vitro-fertilization
#20
John J Zhang, Mingxue Yang, Zaher Merhi
OBJECTIVE: To compare cumulative live birth rate according to the rate of use of metaphase II (MII) oocytes in conventional ovarian stimulation protocols for in vitro fertilization (IVF) or intracytoplasmic sperm injection. METHODS: In a cohort study, patients aged 18-38 years undergoing their first IVF treatment at one US center were enrolled between February 1, 2009, and August 31, 2013. Ovarian response was categorized by the yield of MII oocytes (low: 1-2; intermediate: 3-6; high: ≥7)...
May 2016: International Journal of Gynaecology and Obstetrics
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