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Tendon Pain Models

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4 papers 0 to 25 followers
Stephanie G Dakin, Fernando O Martinez, Clarence Yapp, Graham Wells, Udo Oppermann, Benjamin J F Dean, Richard D J Smith, Kim Wheway, Bridget Watkins, Lucy Roche, Andrew J Carr
Improved understanding of the role of inflammation in tendon disease is required to facilitate therapeutic target discovery. We studied supraspinatus tendons from patients experiencing pain before and after surgical subacromial decompression treatment. Tendons were classified as having early, intermediate, or advanced disease, and inflammation was characterized through activation of pathways mediated by interferon (IFN), nuclear factor κB (NF-κB), glucocorticoid receptor, and signal transducer and activator of transcription 6 (STAT-6)...
October 28, 2015: Science Translational Medicine
Melanie L Plinsinga, Michel S Brink, Bill Vicenzino, C Paul van Wilgen
Study Design Systematic review. Objectives To elucidate if there is sensitization of the nervous system in those with persistent rotator cuff (shoulder), lateral elbow, patellar, and Achilles tendinopathies. Background Tendinopathy can be difficult to treat, and persistent intractable pain and dysfunction are frequent. It is hypothesized that induction or maintenance of persistent pain in tendinopathy may be, at least in part, based on changes in the nervous system. Methods The PRISMA guidelines were followed...
November 2015: Journal of Orthopaedic and Sports Physical Therapy
Sarah L Franklin, Benjamin J F Dean, Kim Wheway, Bridget Watkins, Muhammad K Javaid, Andrew J Carr
BACKGROUND: Pain related to rotator cuff tendinopathy is a common problem, but little is known regarding the origin and cause of pain from the tendon substance. No study to date has looked at the association between tissue changes and patient outcomes. PURPOSE: To describe the peripheral neuronal phenotype in painful rotator cuff tears and to determine correlations between tissue changes and clinical outcome measures. STUDY DESIGN: Controlled laboratory study...
August 2014: American Journal of Sports Medicine
Benjamin John Floyd Dean, Sarah J B Snelling, Stephanie G Dakin, Richard J Murphy, Muhammad Kassim Javaid, Andrew Jonathan Carr
INTRODUCTION: The relationship between peripheral tissue characteristics and pain symptoms in soft tissue inflammation is poorly understood. The primary aim of this study was to determine immunohistochemical differences in tissue obtained from patients with persistent pain and patients who had become pain-free after surgical treatment for rotator cuff tendinopathy. The secondary aim was to investigate whether there would be differences in glutaminergic and inflammatory gene expression between disease-derived and healthy control cells in vitro...
2015: Arthritis Research & Therapy
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