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By P O Pediatrics, Nephrology
Nickolas T Agathis, Ingrid M Libman, Michael L Moritz
Hyponatremia has been reported in the elderly with hypothyroidism and myxedema, but this has not been a universal finding in clinical studies and there have been only a few reports in children. We report a case of an infant who developed hyponatremia due to severe primary hypothyroidism. A 4-month-old ex-preterm male, who had been euthyroid on the newborn screen, developed unexplained hospital-acquired hyponatremia (serum Na 124 mEq/L) while on full oral feeds. He was euvolemic, appeared well and was without myxedema...
2015: Frontiers in Pediatrics
Biff F Palmer, Deborah J Clegg
No abstract text is available yet for this article.
August 6, 2015: New England Journal of Medicine
Aaron Spital
No abstract text is available yet for this article.
September 2015: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Michelle L Gumz, Lawrence Rabinowitz, Charles S Wingo
New England Journal of Medicine, Volume 373, Issue 1, Page 60-72, July 2015.
July 2, 2015: New England Journal of Medicine
Dileep N Lobo, Sherif Awad
The high chloride content of 0.9% saline leads to adverse pathophysiological effects in both animals and healthy human volunteers, changes not seen after balanced crystalloids. Small randomized trials confirm that the hyperchloremic acidosis induced by saline also occurs in patients, but no clinical outcome benefit was demonstrable when compared with balanced crystalloids, perhaps due to a type II error. A strong signal is emerging from recent large propensity-matched and cohort studies for the adverse effects that 0...
December 2014: Kidney International
Can Ince, A B Johan Groeneveld
Although 0.9% NaCl solution is by far the most-used fluid for fluid therapy in resuscitation, it is difficult to find a paper advocating its use over other types of crystalloid solutions. Literature on the deleterious effects of 0.9% NaCl has accumulated over the last decade, but critical appraisal of alternative crystalloid solutions is lacking. As such, the literature seems to suggest that 0.9% NaCl should be avoided at all costs, whereas alternative crystalloid solutions can be used without scrutiny. The basis of this negative evaluation of 0...
December 2014: Kidney International
Richard H Sterns
New England Journal of Medicine, Volume 372, Issue 1, Page 55-65, January 2015.
January 1, 2015: New England Journal of Medicine
Arthur Greenberg, Joseph G Verbalis, Alpesh N Amin, Volker R Burst, Joseph A Chiodo, Jun R Chiong, Joseph F Dasta, Keith E Friend, Paul J Hauptman, Alessandro Peri, Samuel H Sigal
Current management practices for hyponatremia (HN) are incompletely understood. The HN Registry has recorded diagnostic measures, utilization, efficacy, and outcomes of therapy for eu- or hypervolemic HN. To better understand current practices, we analyzed data from 3087 adjudicated adult patients in the registry with serum sodium concentration of 130 mEq/l or less from 225 sites in the United States and European Union. Common initial monotherapy treatments were fluid restriction (35%), administration of isotonic (15%) or hypertonic saline (2%), and tolvaptan (5%); 17% received no active agent...
July 2015: Kidney International
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