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24 papers 0 to 25 followers
Jeong Il Yu, Doo Ho Choi, Seung Jae Huh, Eun Yoon Cho, Kyubo Kim, Eui Kyu Chie, Sung W Ha, In Ae Park, Sung Ja Ahn, Ji Shin Lee, Kyung Hwan Shin, Youngmee Kwon, Yong Bae Kim, Chang-Ok Suh, Ja Seung Koo, Jin Hee Kim, Bae Gwon Jeong, In Ah Kim, Jong Hoon Lee, Won Park
PURPOSE: We designed the present study to investigate differences in prognostic factors and failure patterns between patients with invasive micropapillary carcinoma or carcinoma with micropapillary component (IMPC) and randomly matched patients with invasive ductal carcinoma (IDC) of the breast at multiple institutions of the Korean Radiation Oncology Group (KROG). MATERIALS AND METHODS: This retrospective multicenter study was performed using subjects treated from January 1999 to November 2011...
October 2015: Clinical Breast Cancer
Zhao-Qing Cui, Ji-Huan Feng, Yi-Jun Zhao
The aim of the present study was to evaluate the clinical and immunohistopathological findings of invasive micropapillary carcinoma (IMPC) of the breast. In total, 25 patients were included in the present study, all of whom were diagnosed with IMPC. The mammography and ultrasound scanning (US) findings were analysed retrospectively according to the American College of Radiology Breast Imaging Reporting and Data System lexicon. Surgical specimens obtained from the patients were microscopically reviewed in consensus by two pathologists with a specialisation in breast pathology...
March 2015: Oncology Letters
Amanda Arantes Perez, Débora Balabram, Marcio de Almeida Salles, Helenice Gobbi
BACKGROUND: The histopathological subtype, nuclear grade and presence or absence of comedonecrosis are established as critical elements in the reporting of ductal carcinoma in situ (DCIS) of the breast. The aims of this study were to determine the frequencies of morphological subtypes of DCIS, nuclear grade and comedonecrosis; to compare the age of patients with the histopathological characteristics of DCIS, and to assess the agreement of grade between in situ and invasive components in DCIS cases that were associated with invasive carcinoma...
2014: Diagnostic Pathology
Chih-Hung Lin, Chia-Hsing Liu, Chien-Hui Wen, Pei-Ling Ko, Chee-Yin Chai
Malignant papillary lesions are, in contrast to their benign counterpart, rare malignant tumors in the breast. To differentiate between benign or atypical and malignant papillary lesions can be difficult, especially in core biopsy specimens. In the present study, excisional or more extensive surgical specimens of 33 papillary carcinomas, 2 micropapillary carcinomas, and 17 atypical papillomas of the breast were reviewed and classified according to the latest WHO classification. Thirty-three intraductal papillomas and 49 invasive carcinomas, no special type (NST), were included in the study for comparison...
February 2015: Virchows Archiv: An International Journal of Pathology
Wen-Biao Shi, Lin-Jun Yang, Xin Hu, Jian Zhou, Qiang Zhang, Zhi-Ming Shao
BACKGROUND: Invasive micropapillary carcinoma (IMPC) of the breast is a rare subtype of breast cancer that is associated with a high incidence of regional lymph node metastases and a poor clinical outcome. However, the clinico-pathological features and prognostic factors of IMPC are not well understood. PATIENTS AND METHODS: A total of 188 IMPC cases and 1,289 invasive ductal carcinoma (IDC) cases were included. The clinical features, breast cancer-specific survival (BCSS) and recurrence/metastasis-free survival (RFS) of the patients were compared between these two groups...
2014: PloS One
Shaza Alsharif, Razan Daghistani, Elif Aşik Kamberoğlu, Atilla Omeroglu, Sarkis Meterissian, Benoît Mesurolle
PURPOSE: Describe mammographic, sonographic and MRI findings of invasive micropapillary carcinoma (IMPC) of the breast. MATERIALS AND METHODS: Review of the pathology database identified 43 patients (mean age, 59.3 years) with the diagnosis of breast IMPC. Three patients had no available imaging studies. Mammograms (40), breast ultrasounds (33) and MRIs (8) were retrospectively evaluated by two radiologists in consensus following the BI-RADS Lexicon. Clinical, histopathologic features, as well as hormone status were recorded...
August 2014: European Journal of Radiology
Nadège Gruel, Vanessa Benhamo, Jaydutt Bhalshankar, Tatiana Popova, Paul Fréneaux, Laurent Arnould, Odette Mariani, Marc-Henri Stern, Virginie Raynal, Xavier Sastre-Garau, Roman Rouzier, Olivier Delattre, Anne Vincent-Salomon
INTRODUCTION: Pure invasive micropapillary carcinoma (IMPC) is a special type of breast carcinoma characterised by clusters of cells presenting polarity abnormalities. The biological alterations underlying this pattern remain unknown. METHODS: Pangenomic analysis (n=39), TP53 (n=43) and PIK3CA (n=41) sequencing in a series of IMPCs were performed. A subset of cases was also analysed with whole-exome sequencing (n=4) and RNA sequencing (n=6). Copy number variation profiles were compared with those of oestrogen receptors and grade-matched invasive ductal carcinomas (IDCs) of no special type...
2014: Breast Cancer Research: BCR
Rachael Natrajan, Paul M Wilkerson, Caterina Marchiò, Salvatore Piscuoglio, Charlotte K Y Ng, Patty Wai, Maryou B Lambros, Eleftherios P Samartzis, Konstantin J Dedes, Jessica Frankum, Ilirjana Bajrami, Alicja Kopec, Alan Mackay, Roger A'hern, Kerry Fenwick, Iwanka Kozarewa, Jarle Hakas, Costas Mitsopoulos, David Hardisson, Christopher J Lord, Chandan Kumar-Sinha, Alan Ashworth, Britta Weigelt, Anna Sapino, Arul M Chinnaiyan, Christopher A Maher, Jorge S Reis-Filho
Micropapillary carcinoma (MPC) is a rare histological special type of breast cancer, characterized by an aggressive clinical behaviour and a pattern of copy number aberrations (CNAs) distinct from that of grade- and oestrogen receptor (ER)-matched invasive carcinomas of no special type (IC-NSTs). The aims of this study were to determine whether MPCs are underpinned by a recurrent fusion gene(s) or mutations in 273 genes recurrently mutated in breast cancer. Sixteen MPCs were subjected to microarray-based comparative genomic hybridization (aCGH) analysis and Sequenom OncoCarta mutation analysis...
April 2014: Journal of Pathology
E Mahe, M Farag, O Boutross-Tadross
Micropapillary breast carcinoma has been recognized as a morphologically and biologically distinct form of breast carcinoma. Although data suggest that patient outcomes in cases of micropapillary breast carcinoma do not differ significantly from other breast carcinomas, the impact that a micropapillary component might have on the pathological work-up of a case of breast carcinoma remains an important point of discussion (especially as pertaining to the risk of lymphovascular disease). In this study, we perform an extensive retrospective study of the pathological parameters of seven years of breast surgical pathology cases to explore the relationship that micropapillary morphology might have with other important pathological parameters of a breast cancer case work-up (e...
December 2013: Malaysian Journal of Pathology
Hugo M Horlings, Britta Weigelt, Eric M Anderson, Maryou B Lambros, Alan Mackay, Rachael Natrajan, Charlotte K Y Ng, Felipe C Geyer, Marc J van de Vijver, Jorge S Reis-Filho
Histological special types of breast cancer have distinctive morphological features and account for up to 25 % of all invasive breast cancers. We sought to determine whether at the genomic level, histological special types of breast cancer are distinct from grade- and estrogen receptor (ER)-matched invasive carcinomas of no special type (IC-NSTs), and to define genes whose expression correlates with gene copy number in histological special types of breast cancer. We characterized 59 breast cancers of ten histological special types using array-based comparative genomic hybridization (aCGH)...
November 2013: Breast Cancer Research and Treatment
Hyo Soon Lim, Cherie M Kuzmiak, Seo In Jeong, You Ri Choi, Jin Woong Kim, Ji Shin Lee, Min Ho Park
OBJECTIVE: To analyze the magnetic resonance (MR) imaging findings of invasive micropapillary carcinoma of the breast. MATERIALS AND METHODS: MR images were retrospectively evaluated in 14 patients (age range: 37-67, mean age: 49 years) with pathologically confirmed invasive micropapillary carcinoma of the breast. The enhancement type (mass/non-mass), shape, margin, contrast enhancement, and time-intensity curve pattern on the dynamic study were correlated with the histopathologic features...
July 2013: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
Andrea Vingiani, Patrick Maisonneuve, Patrizia Dell'orto, Gabriel Farante, Nicole Rotmensz, Germana Lissidini, Andres Del Castillo, Giuseppe Renne, Alberto Luini, Marco Colleoni, Giuseppe Viale, Giancarlo Pruneri
AIMS: To ascertain the prognostic relevance of micropapillary carcinoma, a specific type of breast tumour. METHODS AND RESULTS: We interrogated the clinical records of a series of 49 pure micropapillary carcinoma patients and 13 487 invasive ductal carcinoma patients, diagnosed and treated consecutively in our institution over a 9-year time-frame. Compared with invasive ductal carcinoma, patients with micropapillary carcinoma more frequently had moderately differentiated tumours (P = 0...
August 2013: Histopathology
Hasan Gokce, Merih Guray Durak, Mehmet Mustafa Akin, Tulay Canda, Pinar Balci, Hulya Ellidokuz, Binnaz Demirkan, Ilknur Bilkay Gorken, Ali Ibrahim Sevinc, Mehmet Ali Kocdor, Serdar Saydam, Omer Harmancioglu
Invasive micropapillary carcinoma (IMPC) of the breast is an uncommon, highly aggressive breast cancer that may occur in pure and mixed forms. Our aim in this study is to investigate the relationship between clinical, histopathologic, and immunohistochemical features of pure and mixed IMPC cases diagnosed and treated at our institution. One hundred and three IMPC cases diagnosed at our institution over a period of 19 years have been selected. Clinical, histopathologic features, as well as hormone status and c-erb-B2 overexpression of tumors were re-evaluated...
July 2013: Breast Journal
Katie N Jones, Luis S Guimaraes, Carol A Reynolds, Karthik Ghosh, Amy C Degnim, Katrina N Glazebrook
OBJECTIVE: The purpose of this article is to present imaging findings of invasive ductal carcinoma with micropapillary features with clinical and pathologic correlation. MATERIALS AND METHODS: We retrospectively searched our institution's surgical pathology database for patients with pathologically proven invasive ductal carcinoma with micropapillary features. Forty-one patients with images available for review were included in the study. Mammographic, sonographic, and MRI findings were assessed using the American College of Radiology's BI-RADS lexicon...
March 2013: AJR. American Journal of Roentgenology
Albert C Chen, Arnold C Paulino, Mary R Schwartz, Angel A Rodriguez, Barbara L Bass, Jenny C Chang, Bin S Teh
BACKGROUND: Invasive micropapillary carcinoma (IMPC) is a rare and distinct variant of breast carcinoma with a high propensity for regional lymph node involvement. Because of its lymphotropic nature, IMPC is considered to have an unfavorable prognosis when compared with invasive ductal carcinoma (IDC). PATIENTS AND METHODS: This study of 624 patients diagnosed with breast IMPC (2001-2008) listed in the National Cancer Institute's Surveillance, Epidemiology, and End Results (NCI SEER) database was performed to evaluate prognostic factors for disease-specific survival (DSS) and overall survival (OS)...
April 2013: Clinical Breast Cancer
Zeeshan Uddin, Romana Idrees, Kanwal Aftab, Naila Kayani
Invasive micropapillary carcinoma (IMPC) of breast is a morphologically distinct and relatively uncommon variant of invasive ductal carcinoma. It is characterized by small clusters of tumor cells with surrounding clear stromal spaces; a tendency for vascular permeation and therefore, an aggressive clinical course. This morphologic pattern can be easily missed especially in a small biopsy specimen because pathologists may disregard the clear spaces as artifactual. With a tendency of presenting at a higher stage, this morphological pattern needs to be mentioned in the histopathology report whenever it is encountered, either in its pure form or admixed with conventional ductal carcinoma...
May 2012: Breast Journal
Kumiko Kamitani, Takeshi Kamitani, Minoru Ono, Satoshi Toyoshima, Shoshu Mitsuyama
BACKGROUND: Invasive micropapillary carcinoma of the breast (IMPC) has been considered to have no specific image finding. The purpose of this study was to correlate the ultrasonographic findings of IMPC, especially internal echogenicity, with histological findings and to discuss the histological factor that influenced the internal echogenicity. METHODS: Six patients who had undergone surgery at our institute between October 2005 and February 2010 and had been subsequently diagnosed with IMPC were enrolled in this study...
October 2012: Breast Cancer: the Journal of the Japanese Breast Cancer Society
Montse Verdú, Ruth Román, Miquel Calvo, Natàlia Rodón, Beatriz García, Marta González, August Vidal, Xavier Puig
Invasive micropapillary carcinoma is associated with frequent lymph node metastasis and adverse clinical outcome. Initially described as a variant of breast and ovarian carcinoma, it has subsequently been found in other organs, most recently the colon. Reports of colorectal micropapillary carcinoma to date are limited in number, and their molecular profile has not been established. The aims of the present study were to analyze their clinicopathological features and molecular profile, and compare them with those of conventional adenocarcinoma...
May 2011: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
Isabella Castellano, Caterina Marchiò, Mariano Tomatis, Antonio Ponti, Denise Casella, Simonetta Bianchi, Vania Vezzosi, Riccardo Arisio, Francesca Pietribiasi, Alfonso Frigerio, Maria Piera Mano, Umberto Ricardi, Elena Allia, Valeria Accortanzo, Antonio Durando, Giovanni Bussolati, Tibor Tot, Anna Sapino
The clinical significance of micropapillary growth pattern in ductal carcinoma in situ is controversial and the impact of nuclear grading in terms of recurrence of this lesion is yet to be clarified. Our aim was to evaluate, on a series of micropapillary in situ carcinomas, the histological features correlated with recurrence and whether the micropapillary subtype had a different behavior from other non-micropapillary ductal carcinoma in situ. We collected 55 cases of micropapillary in situ carcinomas from four institutions...
February 2010: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
Shir-Hwa Ueng, Thomas Mezzetti, Fattaneh A Tavassoli
CONTEXT: Interpretation of papillary lesions of the breast remains a challenging task because of the wide morphologic spectrum encountered in the benign, atypical, and malignant subtypes. Data on clinical significance and outcome of papillary lesions, with superimposed atypia or areas similar to ductal carcinoma in situ partially replacing the benign elements, are sparse. Furthermore, complete excision of even a fully developed papillary carcinoma confined to a dilated or cystic duct is associated with an excellent prognosis, whereas a complex papilloma extending into multiple branches of a duct may ultimately recur as a carcinoma because of incomplete excision of microscopic foci...
June 2009: Archives of Pathology & Laboratory Medicine
2015-07-31 17:10:21
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