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Benign Hematology

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5 papers 0 to 25 followers
https://www.readbyqxmd.com/read/20048028/myelodysplastic-syndromes-a-practical-approach-to-diagnosis-and-treatment
#1
REVIEW
Afsaneh Barzi, Mikkael A Sekeres
The myelodysplastic syndromes (MDS) are clonal bone marrow disorders that lead to underproduction of normal blood cells. The consequent cytopenias result in infections and bleeding complications. MDS transform to acute myeloid leukemia in one-third of patients. The number of diagnoses has exploded in the past decade as a result of increased recognition and understanding of the disease and the aging of the population. New therapies can extend life. MDS are now considered the most common form of leukemia, and in some cases deserve immediate intervention...
January 2010: Cleveland Clinic Journal of Medicine
https://www.readbyqxmd.com/read/26541251/hodgkin-lymphoma-diagnosis-and-treatment
#2
REVIEW
Stephen M Ansell
Hodgkin lymphoma is a rare B-cell malignant neoplasm affecting approximately 9000 new patients annually. This disease represents approximately 11% of all lymphomas seen in the United States and comprises 2 discrete disease entities--classical Hodgkin lymphoma and nodular lymphocyte-predominant Hodgkin lymphoma. Within the subcategorization of classical Hodgkin lymphoma are defined subgroups: nodular sclerosis, mixed cellularity, lymphocyte depletion, and lymphocyte-rich Hodgkin lymphoma. Staging of this disease is essential for the choice of optimal therapy...
November 2015: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/26445544/new-insights-into-the-mechanisms-of-action-of-aspirin-and-its-use-in-the-prevention-and-treatment-of-arterial-and-venous-thromboembolism
#3
REVIEW
Ymer H Mekaj, Fetije T Daci, Agon Y Mekaj
The antithrombotic action of aspirin has long been recognized. Aspirin inhibits platelet function through irreversible inhibition of cyclooxygenase (COX) activity. Until recently, aspirin has been mainly used for primary and secondary prevention of arterial antithrombotic events. The aim of this study was to review the literature with regard to the various mechanisms of the newly discovered effects of aspirin in the prevention of the initiation and development of venous thrombosis. For this purpose, we used relevant data from the latest numerous scientific studies, including review articles, original research articles, double-blinded randomized controlled trials, a prospective combined analysis, a meta-analysis of randomized trials, evidence-based clinical practice guidelines, and multicenter studies...
2015: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/23617322/long-term-safety-and-efficacy-of-sustained-eculizumab-treatment-in-patients-with-paroxysmal-nocturnal-haemoglobinuria
#4
MULTICENTER STUDY
Peter Hillmen, Petra Muus, Alexander Röth, Modupe O Elebute, Antonio M Risitano, Hubert Schrezenmeier, Jeffrey Szer, Paul Browne, Jaroslaw P Maciejewski, Jörg Schubert, Alvaro Urbano-Ispizua, Carlos de Castro, Gérard Socié, Robert A Brodsky
Paroxysmal nocturnal haemoglobinuria (PNH) is characterized by chronic, uncontrolled complement activation resulting in elevated intravascular haemolysis and morbidities, including fatigue, dyspnoea, abdominal pain, pulmonary hypertension, thrombotic events (TEs) and chronic kidney disease (CKD). The long-term safety and efficacy of eculizumab, a humanized monoclonal antibody that inhibits terminal complement activation, was investigated in 195 patients over 66 months. Four patient deaths were reported, all unrelated to treatment, resulting in a 3-year survival estimate of 97·6%...
July 2013: British Journal of Haematology
https://www.readbyqxmd.com/read/25976966/hepcidin-and-iron-disorders-new-biology-and-clinical-approaches
#5
REVIEW
J Arezes, E Nemeth
Hepatic hormone hepcidin is a principal regulator of iron homeostasis and a pathogenic factor in common iron disorders. Hepcidin deficiency causes iron overload in hereditary hemochromatosis and iron-loading anemias, whereas hepcidin excess causes or contributes to the development of iron-restricted anemia in inflammatory diseases, infections, some cancers, and chronic kidney disease. Because of this, hepcidin may become a useful tool for diagnosis and management of iron disorders. Furthermore, a number of strategies that target hepcidin, its receptor, and its regulators are under development as novel therapeutic approaches for diseases associated with iron dysregulation...
May 2015: International Journal of Laboratory Hematology
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