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https://www.readbyqxmd.com/read/19608703/bicarbonate-supplementation-slows-progression-of-ckd-and-improves-nutritional-status
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RANDOMIZED CONTROLLED TRIAL
Ione de Brito-Ashurst, Mira Varagunam, Martin J Raftery, Muhammad M Yaqoob
Bicarbonate supplementation preserves renal function in experimental chronic kidney disease (CKD), but whether the same benefit occurs in humans is unknown. Here, we randomly assigned 134 adult patients with CKD (creatinine clearance [CrCl] 15 to 30 ml/min per 1.73 m(2)) and serum bicarbonate 16 to 20 mmol/L to either supplementation with oral sodium bicarbonate or standard care for 2 yr. The primary end points were rate of CrCl decline, the proportion of patients with rapid decline of CrCl (>3 ml/min per 1...
September 2009: Journal of the American Society of Nephrology: JASN
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