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Transgenic mice

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Tom Vanden Berghe, Paco Hulpiau, Liesbet Martens, Roosmarijn E Vandenbroucke, Elien Van Wonterghem, Seth W Perry, Inge Bruggeman, Tatyana Divert, Sze Men Choi, Marnik Vuylsteke, Valery I Shestopalov, Claude Libert, Peter Vandenabeele
Targeted mutagenesis in mice is a powerful tool for functional analysis of genes. However, genetic variation between embryonic stem cells (ESCs) used for targeting (previously almost exclusively 129-derived) and recipient strains (often C57BL/6J) typically results in congenic mice in which the targeted gene is flanked by ESC-derived passenger DNA potentially containing mutations. Comparative genomic analysis of 129 and C57BL/6J mouse strains revealed indels and single nucleotide polymorphisms resulting in alternative or aberrant amino acid sequences in 1,084 genes in the 129-strain genome...
July 21, 2015: Immunity
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