collection
MENU ▼
Read by QxMD icon Read
search

Transgenic mice

shared collection
1 papers 0 to 25 followers
https://www.readbyqxmd.com/read/26163370/passenger-mutations-confound-interpretation-of-all-genetically-modified-congenic-mice
#1
Tom Vanden Berghe, Paco Hulpiau, Liesbet Martens, Roosmarijn E Vandenbroucke, Elien Van Wonterghem, Seth W Perry, Inge Bruggeman, Tatyana Divert, Sze Men Choi, Marnik Vuylsteke, Valery I Shestopalov, Claude Libert, Peter Vandenabeele
Targeted mutagenesis in mice is a powerful tool for functional analysis of genes. However, genetic variation between embryonic stem cells (ESCs) used for targeting (previously almost exclusively 129-derived) and recipient strains (often C57BL/6J) typically results in congenic mice in which the targeted gene is flanked by ESC-derived passenger DNA potentially containing mutations. Comparative genomic analysis of 129 and C57BL/6J mouse strains revealed indels and single nucleotide polymorphisms resulting in alternative or aberrant amino acid sequences in 1,084 genes in the 129-strain genome...
July 21, 2015: Immunity
1
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"