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By Fabio Batistuta De Mesquita Fetal medicine studant
Denise A L Pedreira, Nelci Zanon, Koshiro Nishikuni, Renato A Moreira de Sá, Gregório L Acacio, Ramen H Chmait, Eftichia V Kontopoulos, Rubén A Quintero
BACKGROUND: A recent randomized clinical trial named Management of Myelomeningocele Study (MOMS trial) showed that prenatal correction of open spina bifida (OSB) via open fetal surgery was associated with improved infant neurological outcomes relative to postnatal repair, but at the expense of increased maternal morbidity. OBJECTIVE: We sought to report the final results of our phase I trial (Cirurgia Endoscópica para Correção Antenatal da Meningomielocele [CECAM]) on the feasibility, safety, potential benefits, and side effects of the fetoscopic treatment of OSB using our unique surgical technique...
January 2016: American Journal of Obstetrics and Gynecology
Elysia Poggi Davis, Donald Pfaff
During gestation, development proceeds at a pace that is unmatched by any other stage of the life cycle. For these reasons the human fetus is particularly susceptible not only to organizing influences, but also to pathogenic disorganizing influences. Growing evidence suggests that exposure to prenatal adversity leads to neurological changes that underlie lifetime risks for mental illness. Beginning early in gestation, males and females show differential developmental trajectories and responses to stress. It is likely that sex-dependent organization of neural circuits during the fetal period influences differential vulnerability to mental health problems...
November 2014: Psychoneuroendocrinology
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